diff --git a/maintainer/conda/MDAnalysis/meta.yaml b/maintainer/conda/MDAnalysis/meta.yaml
index f2037a87e3a..457d5d6fa6c 100644
--- a/maintainer/conda/MDAnalysis/meta.yaml
+++ b/maintainer/conda/MDAnalysis/meta.yaml
@@ -1,7 +1,7 @@
 package:
   name: mdanalysis
   # This has to be changed after a release
-  version: "2.5.0-dev0"
+  version: "2.4.1"
 
 source:
    git_url: https://github.com/MDAnalysis/mdanalysis
diff --git a/package/CHANGELOG b/package/CHANGELOG
index 4702c20ceb4..c2174570c0a 100644
--- a/package/CHANGELOG
+++ b/package/CHANGELOG
@@ -13,17 +13,12 @@ The rules for this file:
   * release numbers follow "Semantic Versioning" http://semver.org
 
 ------------------------------------------------------------------------------
-??/??/?? IAlibay
+12/17/22 IAlibay
 
- * 2.5.0
+ * 2.4.1
 
 Fixes
-
-Enhancements
-
-Changes
-
-Deprecations
+* Fixes pyproject.toml minimum pin for biopython
 
 
 12/16/22 IAlibay, Luthaf, hmacdope, rafaelpap, jbarnoud, BFedder, aya9aladdin,
diff --git a/package/MDAnalysis/version.py b/package/MDAnalysis/version.py
index b940f838c40..59d5b8cc363 100644
--- a/package/MDAnalysis/version.py
+++ b/package/MDAnalysis/version.py
@@ -67,4 +67,4 @@
 # e.g. with lib.log
 
 #: Release of MDAnalysis as a string, using `semantic versioning`_.
-__version__ = "2.5.0-dev0"  # NOTE: keep in sync with RELEASE in setup.py
+__version__ = "2.4.1"  # NOTE: keep in sync with RELEASE in setup.py
diff --git a/package/pyproject.toml b/package/pyproject.toml
index 13f6b162416..ad168894fd4 100644
--- a/package/pyproject.toml
+++ b/package/pyproject.toml
@@ -40,7 +40,7 @@ maintainers = [
 requires-python = ">=3.8"
 dependencies = [
     'numpy>=1.20.0',
-    'biopython>=1.71',
+    'biopython>=1.80',
     'networkx>=2.0',
     'GridDataFormats>=0.4.0',
     'mmtf-python>=1.0.0',
@@ -84,6 +84,7 @@ extra_formats = [
     "h5py>=2.10",
     "chemfiles>=0.10",
     "pyedr>=0.7.0",
+    "pytng>=0.2.3",
 ]
 analysis = [
     "seaborn",
diff --git a/package/setup.py b/package/setup.py
index 0c6a5446a86..8aad0da2fdc 100755
--- a/package/setup.py
+++ b/package/setup.py
@@ -67,7 +67,7 @@
 from subprocess import getoutput
 
 # NOTE: keep in sync with MDAnalysis.__version__ in version.py
-RELEASE = "2.5.0-dev0"
+RELEASE = "2.4.1"
 
 is_release = 'dev' not in RELEASE
 
diff --git a/testsuite/MDAnalysisTests/__init__.py b/testsuite/MDAnalysisTests/__init__.py
index 5857d1ec30b..9e7a079b224 100644
--- a/testsuite/MDAnalysisTests/__init__.py
+++ b/testsuite/MDAnalysisTests/__init__.py
@@ -97,7 +97,7 @@
 logger = logging.getLogger("MDAnalysisTests.__init__")
 
 # keep in sync with RELEASE in setup.py
-__version__ = "2.5.0-dev0"
+__version__ = "2.4.1"
 
 
 # Do NOT import MDAnalysis at this level. Tests should do it themselves.
diff --git a/testsuite/setup.py b/testsuite/setup.py
index 5e821bda96f..37e0575db98 100755
--- a/testsuite/setup.py
+++ b/testsuite/setup.py
@@ -87,7 +87,7 @@ def run(self):
 
 if __name__ == '__main__':
     # this must be in-sync with MDAnalysis
-    RELEASE = "2.5.0-dev0"
+    RELEASE = "2.4.1"
     with open("README") as summary:
         LONG_DESCRIPTION = summary.read()