diff --git a/sys/include/ztimer/xtimer_compat.h b/sys/include/ztimer/xtimer_compat.h
index daf9cab34c3a3..a84ef867c1d49 100644
--- a/sys/include/ztimer/xtimer_compat.h
+++ b/sys/include/ztimer/xtimer_compat.h
@@ -27,10 +27,12 @@
 /* make sure to overwrite potentially conflicting XTIMER_WIDTH definition from
  * board.h by eagerly including it */
 #include "board.h"
+#include "busy_wait.h"
 #include "timex.h"
 #ifdef MODULE_CORE_MSG
 #include "msg.h"
 #endif /* MODULE_CORE_MSG */
+#include "macros/math.h"
 #include "mutex.h"
 #include "sched.h"
 
@@ -88,6 +90,11 @@ static inline uint32_t xtimer_usec_from_ticks(xtimer_ticks32_t ticks)
     return ticks;
 }
 
+static inline uint32_t xtimer_msec_from_ticks(xtimer_ticks32_t ticks)
+{
+    return ticks * US_PER_MS;
+}
+
 static inline uint64_t xtimer_usec_from_ticks64(xtimer_ticks64_t ticks)
 {
     return ticks;
@@ -105,12 +112,28 @@ static inline xtimer_ticks64_t xtimer_ticks_from_usec64(uint64_t usec)
 
 static inline xtimer_ticks32_t xtimer_now(void)
 {
-    return ztimer_now(ZTIMER_USEC);
+    if (IS_ACTIVE(MODULE_ZTIMER_USEC)) {
+        return ztimer_now(ZTIMER_USEC);
+    }
+    else if (IS_ACTIVE(MODULE_ZTIMER_MSEC)) {
+        return ztimer_now(ZTIMER_MSEC) * US_PER_MS;
+    }
+    else {
+        return 0;
+    }
 }
 
 static inline uint32_t xtimer_now_usec(void)
 {
-    return ztimer_now(ZTIMER_USEC);
+    if (IS_ACTIVE(MODULE_ZTIMER_USEC)) {
+        return ztimer_now(ZTIMER_USEC);
+    }
+    else if (IS_ACTIVE(MODULE_ZTIMER_MSEC)) {
+        return ztimer_now(ZTIMER_MSEC) * US_PER_MS;
+    }
+    else {
+        return 0;
+    }
 }
 
 static inline void _ztimer_sleep_scale(ztimer_clock_t *clock, uint32_t time,
@@ -142,19 +165,30 @@ static inline void xtimer_msleep(uint32_t milliseconds)
     if (IS_ACTIVE(MODULE_ZTIMER_MSEC)) {
         ztimer_sleep(ZTIMER_MSEC, milliseconds);
     }
-    else {
+    else if (IS_ACTIVE(MODULE_ZTIMER_USEC)) {
         _ztimer_sleep_scale(ZTIMER_USEC, milliseconds, US_PER_MS);
     }
+    else {
+        busy_wait_us(US_PER_MS * milliseconds);
+    }
 }
 
 static inline void xtimer_usleep(uint32_t microseconds)
 {
-    ztimer_sleep(ZTIMER_USEC, microseconds);
+    if (IS_ACTIVE(MODULE_ZTIMER_USEC)) {
+        ztimer_sleep(ZTIMER_USEC, microseconds);
+    }
+    else if (IS_ACTIVE(MODULE_ZTIMER_MSEC)) {
+        ztimer_sleep(ZTIMER_MSEC, DIV_ROUND_UP(microseconds, US_PER_MS));
+    }
+    else {
+        busy_wait_us(microseconds);
+    }
 }
 
 static inline void xtimer_nanosleep(uint32_t nanoseconds)
 {
-    ztimer_sleep(ZTIMER_USEC, nanoseconds / NS_PER_US);
+    xtimer_usleep(nanoseconds / NS_PER_US);
 }
 
 static inline void xtimer_tsleep32(xtimer_ticks32_t ticks)
@@ -176,60 +210,141 @@ static inline void xtimer_tsleep64(xtimer_ticks64_t ticks)
 
 static inline void xtimer_set(xtimer_t *timer, uint32_t offset)
 {
-    ztimer_set(ZTIMER_USEC, timer, offset);
+    if (IS_ACTIVE(MODULE_ZTIMER_USEC)) {
+        ztimer_set(ZTIMER_USEC, timer, offset);
+    }
+    else if (IS_ACTIVE(MODULE_ZTIMER_MSEC)) {
+        ztimer_set(ZTIMER_MSEC, timer, DIV_ROUND_UP(offset, US_PER_MS));
+    }
+    else {
+        assert(0);
+    }
 }
 
 static inline void xtimer_remove(xtimer_t *timer)
 {
-    ztimer_remove(ZTIMER_USEC, timer);
+    if (IS_ACTIVE(MODULE_ZTIMER_USEC)) {
+        ztimer_remove(ZTIMER_USEC, timer);
+    }
+    else if (IS_ACTIVE(MODULE_ZTIMER_MSEC)) {
+        ztimer_remove(ZTIMER_MSEC, timer);
+    }
+    else {
+        assert(0);
+    }
 }
 
 static inline void xtimer_set_msg(xtimer_t *timer, uint32_t offset, msg_t *msg,
                                   kernel_pid_t target_pid)
 {
-    ztimer_set_msg(ZTIMER_USEC, timer, offset, msg, target_pid);
+    if (IS_ACTIVE(MODULE_ZTIMER_USEC)) {
+        ztimer_set_msg(ZTIMER_USEC, timer, offset, msg, target_pid);
+    }
+    else if (IS_ACTIVE(MODULE_ZTIMER_MSEC)) {
+        ztimer_set_msg(ZTIMER_MSEC, timer, DIV_ROUND_UP(offset, US_PER_MS),
+                       msg, target_pid);
+    }
+    else {
+        assert(0);
+    }
 }
 
 static inline void xtimer_periodic_wakeup(xtimer_ticks32_t *last_wakeup,
                                           uint32_t period)
 {
-    ztimer_periodic_wakeup(ZTIMER_USEC, last_wakeup, period);
+    if (IS_ACTIVE(MODULE_ZTIMER_USEC)) {
+        ztimer_periodic_wakeup(ZTIMER_USEC, last_wakeup, period);
+    }
+    else if (IS_ACTIVE(MODULE_ZTIMER_MSEC)) {
+        ztimer_periodic_wakeup(ZTIMER_MSEC, last_wakeup, DIV_ROUND_UP(period, US_PER_MS));
+    }
+    else {
+        assert(0);
+    }
 }
 
 static inline int xtimer_msg_receive_timeout(msg_t *msg, uint32_t timeout)
 {
-    return ztimer_msg_receive_timeout(ZTIMER_USEC, msg, timeout);
+    if (IS_ACTIVE(MODULE_ZTIMER_USEC)) {
+        return ztimer_msg_receive_timeout(ZTIMER_USEC, msg, timeout);
+    }
+    else if (IS_ACTIVE(MODULE_ZTIMER_MSEC)) {
+        return ztimer_msg_receive_timeout(ZTIMER_MSEC, msg, DIV_ROUND_UP(timeout, US_PER_MS));
+    }
+    else {
+        assert(0);
+    }
 }
 
 static inline void xtimer_set_wakeup(xtimer_t *timer, uint32_t offset,
                                      kernel_pid_t pid)
 {
-    ztimer_set_wakeup(ZTIMER_USEC, timer, offset, pid);
+    if (IS_ACTIVE(MODULE_ZTIMER_USEC)) {
+        ztimer_set_wakeup(ZTIMER_USEC, timer, offset, pid);
+    }
+    else if (IS_ACTIVE(MODULE_ZTIMER_MSEC)) {
+        ztimer_set_wakeup(ZTIMER_MSEC, timer, DIV_ROUND_UP(offset, US_PER_MS), pid);
+    }
+    else {
+        assert(0);
+    }
 }
 
 static inline int xtimer_mutex_lock_timeout(mutex_t *mutex, uint64_t us)
 {
-    assert(us <= UINT32_MAX);
-    if (ztimer_mutex_lock_timeout(ZTIMER_USEC, mutex, (uint32_t)us)) {
-        /* Impedance matching required: Convert -ECANCELED error code to -1: */
-        return -1;
+    int res;
+
+    if (IS_ACTIVE(MODULE_ZTIMER_USEC)) {
+        assert(us <= UINT32_MAX);
+        res = ztimer_mutex_lock_timeout(ZTIMER_USEC, mutex, (uint32_t)us);
+    }
+    else if (IS_ACTIVE(MODULE_ZTIMER_USEC)) {
+        us = DIV_ROUND_UP(us, US_PER_MS);
+        assert(us <= UINT32_MAX);
+        res = ztimer_mutex_lock_timeout(ZTIMER_SEC, mutex, (uint32_t)us);
+    }
+    else {
+        assert(0);
+        res = -1;
     }
-    return 0;
+
+    /* Impedance matching required: Convert -ECANCELED error code to -1: */
+    return res ? -1 : 0;
 }
 
-static inline int xtimer_rmutex_lock_timeout(rmutex_t *rmutex, uint64_t us)
+static inline int xtimer_rmutex_lock_timeout(rmutex_t *mutex, uint64_t us)
 {
-    assert(us <= UINT32_MAX);
-    if (ztimer_rmutex_lock_timeout(ZTIMER_USEC, rmutex, us)) {
-        /* Impedance matching required: Convert -ECANCELED error code to -1: */
-        return -1;
+    int res;
+
+    if (IS_ACTIVE(MODULE_ZTIMER_USEC)) {
+        assert(us <= UINT32_MAX);
+        res = ztimer_rmutex_lock_timeout(ZTIMER_USEC, mutex, (uint32_t)us);
+    }
+    else if (IS_ACTIVE(MODULE_ZTIMER_USEC)) {
+        us = DIV_ROUND_UP(us, US_PER_MS);
+        assert(us <= UINT32_MAX);
+        res = ztimer_rmutex_lock_timeout(ZTIMER_SEC, mutex, (uint32_t)us);
     }
-    return 0;
+    else {
+        assert(0);
+        res = -1;
+    }
+
+    /* Impedance matching required: Convert -ECANCELED error code to -1: */
+    return res ? -1 : 0;
 }
 
 static inline void xtimer_set_timeout_flag(xtimer_t *t, uint32_t timeout)
 {
-    ztimer_set_timeout_flag(ZTIMER_USEC, t, timeout);
+    if (IS_ACTIVE(MODULE_ZTIMER_USEC)) {
+        ztimer_set_timeout_flag(ZTIMER_USEC, t, timeout);
+    }
+    else if (IS_ACTIVE(MODULE_ZTIMER_USEC)) {
+        ztimer_set_timeout_flag(ZTIMER_USEC, t, DIV_ROUND_UP(timeout, US_PER_MS));
+    }
+    else {
+        assert(0);
+    }
 }
 
 static inline void xtimer_set_timeout_flag64(xtimer_t *t, uint64_t timeout)
@@ -240,7 +355,15 @@ static inline void xtimer_set_timeout_flag64(xtimer_t *t, uint64_t timeout)
 
 static inline void xtimer_spin(xtimer_ticks32_t ticks)
 {
-    ztimer_spin(ZTIMER_USEC, xtimer_usec_from_ticks(ticks));
+    if (IS_ACTIVE(MODULE_ZTIMER_USEC)) {
+        ztimer_spin(ZTIMER_USEC, xtimer_usec_from_ticks(ticks));
+    }
+    else if (IS_ACTIVE(MODULE_ZTIMER_MSEC)) {
+        ztimer_spin(ZTIMER_MSEC, xtimer_msec_from_ticks(ticks));
+    }
+    else {
+        busy_wait_us(xtimer_usec_from_ticks(ticks));
+    }
 }
 
 static inline xtimer_ticks32_t xtimer_diff(xtimer_ticks32_t a,