diff --git a/src/remake.jl b/src/remake.jl
index 2008ece21..ca62081a2 100644
--- a/src/remake.jl
+++ b/src/remake.jl
@@ -986,6 +986,7 @@ function fill_vars(
     end
     for (k, v) in varmap
         haskey(sym_to_idx, k) && continue
+        v === nothing && continue
         newvals[k] = v
     end
     return newvals
diff --git a/test/downstream/modelingtoolkit_remake.jl b/test/downstream/modelingtoolkit_remake.jl
index 75c5965dd..ed0da7d2c 100644
--- a/test/downstream/modelingtoolkit_remake.jl
+++ b/test/downstream/modelingtoolkit_remake.jl
@@ -397,3 +397,12 @@ end
     # old value retained
     @test prob2.ps[Gamma] ≈ 3.0
 end
+
+@testset "`nothing` value for variable specified as `Symbol`" begin
+    @variables x(t) [guess = 1.0] y(t) [guess = 1.0]
+    @parameters p [guess = 1.0] q [guess = 1.0]
+    @mtkbuild sys = ODESystem(
+        [D(x) ~ p * x + q * y, y ~ 2x], t; parameter_dependencies = [q ~ 2p])
+    prob = ODEProblem(sys, [:x => 1.0], (0.0, 1.0), [p => 1.0])
+    @test_nowarn remake(prob; u0 = [:y => 1.0, :x => nothing])
+end