data

Processed Datasets

• age_phenotype.csv

  • The file contains the precise age (in days) at which the mouse was assayed for a particular phenotype.

• bodyweight.csv

  • The file contains body weight and corresponding latent states. The row indices are explained below:
    • bw: Body weight sampled at 10 day interval. Starts at 30 day and ends at 1640 days. Enteries are filled with nans if the mouse has died prior to 1640 days.
    • states: Latent state assigned at each time point obtained using a variational-inference based autoregressive hidden Markov model.
    • transitions: Mouse-specific transition state probabilities (tilda_Ps).
    • phenotypes: A two-letter code assigned to particular time point if there is a phenotyping event at the steady state perturbation event. If there is no phenotyping event, then it is a blank string.
    • homeostasis: It is the adapation to stress after a specific perturbation event. The value is assigned to the time point which denotes the end of the perturbation event.
    • events: Time points that indicate the start of a perturbation event are set to 1.0. Similarly, time points that indicate the end of a perturbation event are set to 2.0.
    • bw_rec: Reconstructed body weight obtained using the tilda_eta values as the autoregressive coefficients.
    • pi_x: The probability of being in the latent state x, where x represents growth, steady, or decline.
    • st_i_j: The probability of transitioning from state j to state i, where i and j represent the latent states at time t.

• diet_covariates.csv

  • This file contains diet as covariates

• generation_covariates.csv

  • This file contains generation as covariates

• kinship_matrix.genoprob.csv

  • This file contains the kinship matrix

• lifespan.csv

  • This file contains contains mouse ids, date of birth and death, and lifespan (in days).

• pll.csv

  • This file contains proportion of life lived body weight-derived phenotypes at every 10% interval.

• prepost.csv

  • This file contains pre- and post-intervention phenotypes. The pre-intervention phase starts at 30 days and ends at 180 days. The post-interventions phase starts at 180 days and continues until end of lifespan.

• timeint.csv

  • This file contains body weight-derived phenotypes computed at every six-month interval.