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XDY+S:R346T( 53 seqs,>10 places, 6 with S:Q677H+S:H445R LP.8-mimic) #2866

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xz-keg opened this issue Jan 15, 2025 · 2 comments
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XDY+S:R346T( 53 seqs,>10 places, 6 with S:Q677H+S:H445R LP.8-mimic) #2866

xz-keg opened this issue Jan 15, 2025 · 2 comments

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@xz-keg
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xz-keg commented Jan 15, 2025

From sars-cov-2-variants/lineage-proposals#1784

XDY+G22599C(S:R346T)

GISAID query: : -A26555T,G22599C, C23039G, G24872T, G22131C, G19669A
GISAID query for S:Q677H-S:H445R branch: 22896G ,C2121T, C25714T
No. of seqs: 53(Australia 6 Belgium 1 Canada 2 Hong Kong 1 India 1 Israel 2 Malaysia 1 Netherlands 1 New Zealand 1 UK 1 Singapore 10 Slovenia 2 Spain 12 Thailand 1 USA 11(CA,TX,MD,NJ,VA,GBW from Japan, Denmark))

First: EPI_ISL_19215275, Spain, 2024-6-14
Latest: EPI_ISL_19646663, Singapore, 2024-12-30

usher
The whole branch is placed before XDY as usher places XDY under LB.1.2.1+S:Q493E,V1104L+T346R reversion branch, and this branch have S:346 again mutated to T. Everything here except for the S:T346R branches shall belong to this .

@corneliusroemer @AngieHinrichs either include these seqs into XDY designation, or designate it as XDY.x, they shall not be viewed as LB.1.2.1.

image

There is also an S:Q677H-H445R sub-branch emerging, mimicing the S:31del+R346T+H445R+F456L+Q493E LP.8-combo.

image

@FedeGueli
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The S:Q677H branch should be specified with its two further branches one with Orf1b:K82R (query:A13712G,G23593C, C22858T ) and the other with S:H445R:

Imagehttps://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/hgPhyloPlace/subtreeAuspice1_genome_test_7f23_a81c30.json?c=gt-S_445&label=id:node_7162092

@FedeGueli
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7 for the 445R branch again Singapore

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