diff --git a/q2_sourmash/_compute.py b/q2_sourmash/_compute.py
index 8b3396b..926785c 100644
--- a/q2_sourmash/_compute.py
+++ b/q2_sourmash/_compute.py
@@ -7,6 +7,7 @@
 # ----------------------------------------------------------------------------
 
 from q2_types.per_sample_sequences import SingleLanePerSampleSingleEndFastqDirFmt, FastqGzFormat
+from q2_types.feature_data import DNAIterator
 import qiime2.util
 import pandas as pd
 from q2_sourmash._format import MinHashSigJsonDirFormat
@@ -14,6 +15,41 @@
 import subprocess
 import glob
 import sys
+import tempfile
+import shutil
+
+def compute_fasta(sequence_file: DNAIterator,
+                  ksizes: int,
+                  scaled: int,
+                  track_abundance: bool=True) -> MinHashSigJsonDirFormat:
+    output = MinHashSigJsonDirFormat()
+
+    # write files in tmp dir
+    #with tempfile.TemporaryDirectory() as temp_dir:
+    for seq in sequence_file:
+        tmp_fp = os.path.join(str(output), str(seq.metadata['id']) + '.fasta')
+        with open(tmp_fp, 'w') as indiv_fasta:
+            seq.write(indiv_fasta)
+
+    command = ['sourmash',
+               'compute',
+               str(output) + "/*",
+               '--ksizes',
+               str(ksizes),
+               '--scaled',
+               str(scaled)]
+
+    if track_abundance:
+        command.append('--track-abundance')
+
+    subprocess.run(' '.join(command), check=True, shell=True, cwd=str(output))
+
+    for seq_file in glob.glob(os.path.join(str(output), '*fasta')):
+        os.remove(seq_file)
+
+    sys.stdout.flush()
+
+    return output
 
 
 def compute(sequence_file:SingleLanePerSampleSingleEndFastqDirFmt, ksizes: int, scaled: int, track_abundance: bool=True) -> MinHashSigJsonDirFormat:
diff --git a/q2_sourmash/plugin_setup.py b/q2_sourmash/plugin_setup.py
index 2a01248..282bf25 100644
--- a/q2_sourmash/plugin_setup.py
+++ b/q2_sourmash/plugin_setup.py
@@ -13,10 +13,11 @@
 from qiime2.plugin import Plugin, Metadata, Str, List, Citations, SemanticType, TextFileFormat, ValidationError
 from qiime2.plugin import model
 import qiime2.util
-from q2_sourmash._compute import compute
+from q2_sourmash._compute import compute, compute_fasta
 from q2_sourmash._compare import compare
 from q2_types.distance_matrix import DistanceMatrix
 from q2_types.sample_data import SampleData
+from q2_types.feature_data import FeatureData, Sequence
 from q2_types.per_sample_sequences import SequencesWithQuality
 from ._format import MinHashSigJsonDirFormat, MinHashSigJson
 from ._types import MinHashSig
@@ -41,6 +42,17 @@
 plugin.register_views(MinHashSigJson, MinHashSigJsonDirFormat)
 plugin.register_semantic_types(MinHashSig)
 
+plugin.methods.register_function(
+    function=compute_fasta,
+    inputs={'sequence_file': FeatureData[Sequence]},
+    parameters={'ksizes': qiime2.plugin.Int,
+        'scaled': qiime2.plugin.Int,
+        'track_abundance': qiime2.plugin.Bool},
+    outputs=[('min_hash_signature', MinHashSig)],
+    name = 'compute sourmash signature',
+    description = 'Computes a sourmash MinHash signature from genome fasta files.'
+)
+
 plugin.methods.register_function(
     function=compute,
     inputs={'sequence_file': SampleData[SequencesWithQuality]},