diff --git a/easybuild/easyconfigs/b/BAMSurgeon/BAMSurgeon-1.2-GCC-8.3.0-Python-2.7.16.eb b/easybuild/easyconfigs/b/BAMSurgeon/BAMSurgeon-1.2-GCC-8.3.0-Python-2.7.16.eb
index 20ce4bdd8d2..2aadd350563 100644
--- a/easybuild/easyconfigs/b/BAMSurgeon/BAMSurgeon-1.2-GCC-8.3.0-Python-2.7.16.eb
+++ b/easybuild/easyconfigs/b/BAMSurgeon/BAMSurgeon-1.2-GCC-8.3.0-Python-2.7.16.eb
@@ -21,6 +21,7 @@ dependencies = [
     ('Velvet', '1.2.10', '-mt-kmer_191'),
     ('Exonerate', '2.4.0'),
     ('Pysam', '0.15.3'),
+    ('PyVCF', '0.6.8'),
 ]
 
 download_dep_fail = True
@@ -33,6 +34,11 @@ sanity_check_paths = {
     'dirs': ['lib/python%(pyshortver)s/site-packages'],
 }
 
+sanity_check_commands = [
+    "evaluator.py --help",  # requires PyVCF
+    "postprocess.py --help",
+]
+
 sanity_pip_check = True
 
 moduleclass = 'bio'
diff --git a/easybuild/easyconfigs/p/PyVCF/PyVCF-0.6.8-GCC-8.3.0.eb b/easybuild/easyconfigs/p/PyVCF/PyVCF-0.6.8-GCC-8.3.0.eb
new file mode 100644
index 00000000000..c7761dfa305
--- /dev/null
+++ b/easybuild/easyconfigs/p/PyVCF/PyVCF-0.6.8-GCC-8.3.0.eb
@@ -0,0 +1,36 @@
+easyblock = 'PythonPackage'
+
+name = 'PyVCF'
+version = '0.6.8'
+
+homepage = 'https://github.com/jamescasbon/PyVCF'
+description = "A Variant Call Format reader for Python."
+
+toolchain = {'name': 'GCC', 'version': '8.3.0'}
+
+source_urls = [PYPI_SOURCE]
+sources = [SOURCE_TAR_GZ]
+checksums = ['e9d872513d179d229ab61da47a33f42726e9613784d1cb2bac3f8e2642f6f9d9']
+
+multi_deps = {'Python': ['3.7.4', '2.7.16']}
+
+dependencies = [('Pysam', '0.15.3')]
+
+download_dep_fail = True
+use_pip = True
+
+options = {'modulename': 'vcf'}
+
+sanity_check_paths = {
+    'files': ['bin/vcf_filter.py', 'bin/vcf_melt', 'bin/vcf_sample_filter.py'],
+    'dirs': [],
+}
+
+sanity_check_commands = [
+    "vcf_filter.py --help",
+    "vcf_sample_filter.py --help"
+]
+
+sanity_pip_check = True
+
+moduleclass = 'bio'