diff --git a/.github/workflows/docker.yml b/.github/workflows/docker.yml
new file mode 100644
index 000000000..8a79f74d4
--- /dev/null
+++ b/.github/workflows/docker.yml
@@ -0,0 +1,51 @@
+name: Create and publish a Docker image
+
+on:
+  push:
+    branches:
+      - "master"
+  release:
+    types: [published]
+  workflow_dispatch:
+
+env:
+  REGISTRY: ghcr.io
+  IMAGE_NAME: ${{ github.repository }}
+
+jobs:
+  build-and-push-image:
+    runs-on: ubuntu-latest
+    permissions:
+      contents: read
+      packages: write
+    steps:
+      - name: Checkout repository
+        uses: actions/checkout@v3
+
+      - name: Set up QEMU
+        uses: docker/setup-qemu-action@v2
+
+      - name: Set up Docker Buildx
+        uses: docker/setup-buildx-action@v2
+
+      - name: Log in to the Container registry
+        uses: docker/login-action@f054a8b539a109f9f41c372932f1ae047eff08c9
+        with:
+          registry: ${{ env.REGISTRY }}
+          username: ${{ github.actor }}
+          password: ${{ secrets.GITHUB_TOKEN }}
+
+      - name: Extract metadata (tags, labels) for Docker
+        id: meta
+        uses: docker/metadata-action@98669ae865ea3cffbcbaa878cf57c20bbf1c6c38
+        with:
+          images: ${{ env.REGISTRY }}/${{ env.IMAGE_NAME }}
+
+      - name: Build and push Docker image
+        uses: docker/build-push-action@ad44023a93711e3deb337508980b4b5e9bcdc5dc
+        with:
+          context: .
+          platforms: linux/amd64,linux/arm64
+          push: true
+          tags: ${{ steps.meta.outputs.tags }}
+          labels: ${{ steps.meta.outputs.labels }}
diff --git a/Dockerfile b/Dockerfile
index 25f45adfa..1ee5c3b78 100644
--- a/Dockerfile
+++ b/Dockerfile
@@ -1,65 +1,54 @@
-ARG NAMESPACE=
-FROM debian:stable-slim as qemu-downloader
-ARG NAMESPACE
-RUN if [ X"$NAMESPACE" != X"" ]; then \
-        apt-get update && apt-get install -y wget && rm -rf /var/lib/apt/lists/*; \
-    fi; \
-    if [ X"$NAMESPACE" = X"ppc64le/" ]; then \
-        wget -nv -O /usr/bin/qemu-ppc64le-static https://github.com/multiarch/qemu-user-static/releases/download/v4.2.0-4/qemu-ppc64le-static; \
-        chmod +x /usr/bin/qemu-ppc64le-static; \
-    fi; \
-    if [ X"$NAMESPACE" = X"aarch64/" ]; then \
-        wget -nv -O /usr/bin/qemu-aarch64-static https://github.com/multiarch/qemu-user-static/releases/download/v4.2.0-4/qemu-aarch64-static; \
-        chmod +x /usr/bin/qemu-aarch64-static; \
-    fi; \
-    touch /usr/bin/dummy_copy
-
-FROM ${NAMESPACE}debian:stable-slim as builder
-ARG NAMESPACE
-COPY --from=qemu-downloader /usr/bin/dummy_copy /usr/bin/qemu-aarch64-static* /usr/bin/qemu-ppc64le-static* /usr/bin/
-
-RUN apt-get update && apt-get install -y \
-    build-essential cmake xxd git zlib1g-dev libbz2-dev libatomic1 \
- && rm -rf /var/lib/apt/lists/*
+ARG APP=mmseqs
+FROM --platform=$BUILDPLATFORM debian:stable-slim as builder
+ARG TARGETARCH
+ARG APP
+
+RUN dpkg --add-architecture $TARGETARCH \
+    && apt-get update \
+    && apt-get install -y \
+      build-essential cmake xxd git \
+      zlib1g-dev libbz2-dev libatomic1 \
+      crossbuild-essential-$TARGETARCH zlib1g-dev:$TARGETARCH libbz2-dev:$TARGETARCH \
+    && rm -rf /var/lib/apt/lists/*
 
-WORKDIR /opt/mmseqs
+WORKDIR /opt/build
 ADD . .
 
-RUN mkdir -p build_sse2/src && mkdir -p build_sse41/src && mkdir -p build_avx/src && mkdir -p build/src; \
-    if [ X"$NAMESPACE" = X"" ]; then \
-       cd /opt/mmseqs/build_sse2; \
-       cmake -DHAVE_SSE2=1 -DHAVE_MPI=0 -DHAVE_TESTS=0 -DCMAKE_BUILD_TYPE=Release -DCMAKE_INSTALL_PREFIX=. ..; \
-       make -j $(nproc --all); \
-       mv src/mmseqs /opt/mmseqs/mmseqs_sse2; \
-       cd /opt/mmseqs/build_sse41; \
-       cmake -DHAVE_SSE4_1=1 -DHAVE_MPI=0 -DHAVE_TESTS=0 -DCMAKE_BUILD_TYPE=Release -DCMAKE_INSTALL_PREFIX=. ..; \
-       make -j $(nproc --all); \
-       mv src/mmseqs /opt/mmseqs/mmseqs_sse41; \
-       cd /opt/mmseqs/build_avx; \
-       cmake -DHAVE_AVX2=1 -DHAVE_MPI=0 -DHAVE_TESTS=0 -DCMAKE_BUILD_TYPE=Release -DCMAKE_INSTALL_PREFIX=. ..; \
-       make -j $(nproc --all); \
-       mv src/mmseqs /opt/mmseqs/mmseqs_avx2; \
-       touch /opt/mmseqs/mmseqs_arch; \
-     else \
-       cd /opt/mmseqs/build; \
-       cmake -DHAVE_MPI=0 -DHAVE_TESTS=0 -DCMAKE_BUILD_TYPE=Release -DCMAKE_INSTALL_PREFIX=. ..; \
-       make -j $(nproc --all); \
-       mv src/mmseqs /opt/mmseqs/mmseqs_arch; \
-       touch /opt/mmseqs/mmseqs_sse2 /opt/mmseqs/mmseqs_sse42 /opt/mmseqs/mmseqs_avx2; \
-     fi
-
-FROM ${NAMESPACE}debian:stable-slim
-ARG NAMESPACE
-MAINTAINER Milot Mirdita <milot@mirdita.de>
-COPY --from=qemu-downloader /usr/bin/dummy_copy /usr/bin/qemu-aarch64-static* /usr/bin/qemu-ppc64le-static* /usr/bin/
+RUN if [ "$TARGETARCH" = "arm64" ]; then \
+      mkdir -p build_$TARGETARCH/src; \
+      cd /opt/build/build_$TARGETARCH; \
+      CC=aarch64-linux-gnu-gcc CXX=aarch64-linux-gnu-g++ cmake -DHAVE_ARM8=1 -DHAVE_MPI=0 -DHAVE_TESTS=0 -DCMAKE_BUILD_TYPE=Release -DCMAKE_INSTALL_PREFIX=. ..; \
+      make -j $(nproc --all); \
+      mv src/${APP} /opt/build/${APP}_arch; \
+      touch /opt/build/${APP}_sse2 /opt/build/${APP}_sse41 /opt/build/${APP}_avx2; \
+    else \
+      mkdir -p build_sse2/src && mkdir -p build_sse41/src && mkdir -p build_avx2/src; \
+      cd /opt/build/build_sse2; \
+      cmake -DHAVE_SSE2=1 -DHAVE_MPI=0 -DHAVE_TESTS=0 -DCMAKE_BUILD_TYPE=Release -DCMAKE_INSTALL_PREFIX=. ..; \
+      make -j $(nproc --all); \
+      mv src/${APP} /opt/build/${APP}_sse2; \
+      cd /opt/build/build_sse41; \
+      cmake -DHAVE_SSE4_1=1 -DHAVE_MPI=0 -DHAVE_TESTS=0 -DCMAKE_BUILD_TYPE=Release -DCMAKE_INSTALL_PREFIX=. ..; \
+      make -j $(nproc --all); \
+      mv src/${APP} /opt/build/${APP}_sse41; \
+      cd /opt/build/build_avx2; \
+      cmake -DHAVE_AVX2=1 -DHAVE_MPI=0 -DHAVE_TESTS=0 -DCMAKE_BUILD_TYPE=Release -DCMAKE_INSTALL_PREFIX=. ..; \
+      make -j $(nproc --all); \
+      mv src/${APP} /opt/build/${APP}_avx2; \
+      touch /opt/build/${APP}_arch; \
+    fi
+
+FROM debian:stable-slim
+ARG TARGETARCH
+ARG APP
 
 RUN apt-get update && apt-get install -y \
       gawk bash grep libstdc++6 libgomp1 libatomic1 zlib1g libbz2-1.0 wget tar \
     && rm -rf /var/lib/apt/lists/*
 
-COPY --from=builder /opt/mmseqs/mmseqs_arch /opt/mmseqs/mmseqs_sse2 /opt/mmseqs/mmseqs_sse41 /opt/mmseqs/mmseqs_avx2 /usr/local/bin/
-ADD util/mmseqs_wrapper.sh /usr/local/bin/mmseqs
-RUN if [ X"$NAMESPACE" != X"" ]; then mv -f /usr/local/bin/mmseqs_arch /usr/local/bin/mmseqs; fi
+COPY --from=builder /opt/build/${APP}_arch /opt/build/${APP}_sse2 /opt/build/${APP}_sse41 /opt/build/${APP}_avx2 /usr/local/bin/
+ADD util/${APP}_wrapper.sh /usr/local/bin/entrypoint
+RUN if [ "$TARGETARCH" = "arm64" ]; then rm -f /usr/local/bin/entrypoint; ln -s /usr/local/bin/${APP}_arch /usr/local/bin/entrypoint; fi
 
-CMD ["/usr/local/bin/mmseqs"]
+ENTRYPOINT ["/usr/local/bin/entrypoint"]