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Convert Genetic Maps #163

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gaynorr opened this issue Nov 3, 2023 · 0 comments
Open

Convert Genetic Maps #163

gaynorr opened this issue Nov 3, 2023 · 0 comments

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@gaynorr
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gaynorr commented Nov 3, 2023

Is your feature request related to a problem? Please describe.
Currently, changing the amount of crossover interference does not change the genetic map. This means that the expected number of recombinations is being held constant. However, it would be better to hold the recombination rate constant instead since this is consistent with how recombination is measured and maps are generated.

Describe the solution you'd like
Genetic mapping functions for any combination of parameters in the gamma sprinkling model are needed. When changing parameters, the map needs to be adjusted accordingly to keep recombination frequency constant. This is similar to how a genetic map built with the Haldane function can be converted to a map using the Kosambi function.

This article will provide a helpful starting point: https://academic.oup.com/genetics/article/142/4/1369/6222027

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