diff --git a/src/ontology/go-edit.obo b/src/ontology/go-edit.obo
index 7ff2ba6060..bccdab1ff5 100644
--- a/src/ontology/go-edit.obo
+++ b/src/ontology/go-edit.obo
@@ -51196,7 +51196,7 @@ xref: Wikipedia:Norepinephrine_transporter
 intersection_of: GO:0015293 ! symporter activity
 intersection_of: has_primary_input CHEBI:17996 ! chloride
 intersection_of: has_primary_input CHEBI:29101 ! sodium(1+)
-intersection_of: has_primary_input CHEBI:33569 ! noradrenaline
+intersection_of: has_primary_input CHEBI:72587 ! (R)-noradrenaline
 relationship: part_of GO:0051620 ! norepinephrine uptake
 
 [Term]
@@ -96144,7 +96144,7 @@ synonym: "phytochromobilin biosynthesis" EXACT []
 synonym: "phytochromobilin formation" EXACT []
 synonym: "phytochromobilin synthesis" EXACT []
 intersection_of: GO:0009058 ! biosynthetic process
-intersection_of: has_primary_output CHEBI:26116 ! phytochromobilin
+intersection_of: has_primary_output CHEBI:57439 ! (3Z)-phytochromobilin
 
 [Term]
 id: GO:0010025
@@ -115453,7 +115453,7 @@ synonym: "levarterenol transport" EXACT []
 synonym: "noradrenaline transport" EXACT []
 is_a: GO:0051937 ! catecholamine transport
 intersection_of: GO:0006810 ! transport
-intersection_of: has_primary_input CHEBI:33569 ! noradrenaline
+intersection_of: has_primary_input CHEBI:72587 ! (R)-noradrenaline
 
 [Term]
 id: GO:0015875
@@ -189618,7 +189618,7 @@ def: "The chemical reactions and pathways involving O-glucosylated derivatives o
 synonym: "kaempferol O-glucoside metabolism" EXACT []
 is_a: GO:0016137 ! glycoside metabolic process
 intersection_of: GO:0008152 ! metabolic process
-intersection_of: has_primary_input_or_output CHEBI:30200 ! kaempferol 3-O-beta-D-glucoside
+intersection_of: has_primary_input_or_output CHEBI:169942 ! kaempferol 3-0-beta-D-glucoside(1-)
 
 [Term]
 id: GO:0033330
@@ -189633,7 +189633,7 @@ xref: MetaCyc:PWY-5320
 is_a: GO:0016138 ! glycoside biosynthetic process
 is_a: GO:0033329 ! kaempferol O-glucoside metabolic process
 intersection_of: GO:0009058 ! biosynthetic process
-intersection_of: has_primary_output CHEBI:30200 ! kaempferol 3-O-beta-D-glucoside
+intersection_of: has_primary_output CHEBI:169942 ! kaempferol 3-O-beta-D-glucoside(1-)
 
 [Term]
 id: GO:0033331
@@ -233830,7 +233830,7 @@ synonym: "noradrenaline metabolic process" EXACT []
 synonym: "noradrenaline metabolism" EXACT []
 synonym: "norepinephrine metabolism" EXACT []
 intersection_of: GO:0008152 ! metabolic process
-intersection_of: has_primary_input_or_output CHEBI:33569 ! noradrenaline
+intersection_of: has_primary_input_or_output CHEBI:72587 ! (R)-noradrenaline
 
 [Term]
 id: GO:0042416
@@ -233905,7 +233905,7 @@ synonym: "norepinephrine biosynthesis" EXACT []
 synonym: "norepinephrine formation" EXACT []
 synonym: "norepinephrine synthesis" EXACT []
 intersection_of: GO:0009058 ! biosynthetic process
-intersection_of: has_primary_output CHEBI:33569 ! noradrenaline
+intersection_of: has_primary_output CHEBI:72587 ! (R)-noradrenaline
 
 [Term]
 id: GO:0042422
@@ -233921,7 +233921,7 @@ synonym: "norepinephrine catabolism" EXACT []
 synonym: "norepinephrine degradation" EXACT []
 xref: Wikipedia:Norepinephrine#Degradation
 intersection_of: GO:0009056 ! catabolic process
-intersection_of: has_primary_input CHEBI:33569 ! noradrenaline
+intersection_of: has_primary_input CHEBI:72587 ! (R)-noradrenaline
 
 [Term]
 id: GO:0042423
@@ -248949,7 +248949,7 @@ namespace: molecular_function
 def: "Binding to suramin, a naphthalenesulfonic acid compound which is used in the treatment of diseases caused by trypanosomes and worms." [GOC:jl, Wikipedia:Suramin]
 synonym: "Germanin binding" EXACT []
 intersection_of: GO:0005488 ! binding
-intersection_of: has_input CHEBI:45906 ! suramin
+intersection_of: has_input CHEBI:180911 ! suramin(6-)
 
 [Term]
 id: GO:0043927
@@ -296299,7 +296299,7 @@ def: "The regulated release of norepinephrine by a cell. Norepinephrine is a cat
 synonym: "noradrenaline secretion" EXACT []
 is_a: GO:0023061 ! signal release
 intersection_of: GO:0046903 ! secretion
-intersection_of: has_primary_input CHEBI:33569 ! noradrenaline
+intersection_of: has_primary_input CHEBI:72587 ! (R)-noradrenaline
 
 [Term]
 id: GO:0048244
@@ -320078,7 +320078,7 @@ namespace: molecular_function
 def: "Binding to norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai]
 synonym: "noradrenaline binding" EXACT []
 intersection_of: GO:0005488 ! binding
-intersection_of: has_input CHEBI:33569 ! noradrenaline
+intersection_of: has_input CHEBI:72587 ! (R)-noradrenaline
 
 [Term]
 id: GO:0051381
@@ -322765,7 +322765,7 @@ synonym: "noradrenaline uptake" EXACT []
 synonym: "norepinephrine import" EXACT [GOC:dph, GOC:tb]
 synonym: "norepinephrine reuptake" EXACT []
 intersection_of: GO:0006810 ! transport
-intersection_of: has_primary_input CHEBI:33569 ! noradrenaline
+intersection_of: has_primary_input CHEBI:72587 ! (R)-noradrenaline
 intersection_of: has_target_end_location GO:0005622 ! intracellular anatomical structure
 intersection_of: has_target_start_location GO:0005576 ! extracellular region
 
@@ -381495,7 +381495,7 @@ comment: Note that epinephrine and norepinephrine are ligands for the same recep
 synonym: "response to noradrenaline stimulus" EXACT [GOC:mah]
 synonym: "response to norepinephrine stimulus" EXACT [GOC:dos]
 intersection_of: GO:0050896 ! response to stimulus
-intersection_of: has_input CHEBI:33569 ! noradrenaline
+intersection_of: has_input CHEBI:72587 ! (R)-noradrenaline
 created_by: mah
 creation_date: 2010-09-13T03:31:53Z
 
@@ -381507,7 +381507,7 @@ def: "Any process that results in a change in state or activity of a cell (in te
 comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors.
 synonym: "cellular response to noradrenaline stimulus" EXACT [GOC:mah]
 intersection_of: GO:0070887 ! cellular response to chemical stimulus
-intersection_of: has_input CHEBI:33569 ! noradrenaline
+intersection_of: has_input CHEBI:72587 ! (R)-noradrenaline
 created_by: mah
 creation_date: 2010-09-13T03:33:32Z
 
@@ -420867,7 +420867,7 @@ namespace: biological_process
 def: "The vesicular release of noradrenaline (norepinephrine) a presynapse, across a chemical synapse, the subsequent activation of noradrenaline receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, GOC:dph]
 synonym: "noradrenergic synaptic transmission" EXACT []
 is_a: GO:0007268 ! chemical synaptic transmission
-relationship: has_participant CHEBI:33569 ! noradrenaline
+relationship: has_participant CHEBI:72587 ! (R)-noradrenaline
 created_by: dos
 creation_date: 2017-07-05T14:36:55Z
 
@@ -473010,7 +473010,7 @@ namespace: biological_process
 def: "The chemical reactions and pathways involving bacitracin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00179]
 synonym: "bacitracin A metabolism" EXACT [GOC:TermGenie]
 intersection_of: GO:0008152 ! metabolic process
-intersection_of: has_primary_input_or_output CHEBI:35862 ! bacitracin A
+intersection_of: has_primary_input_or_output CHEBI:184381 ! bacitracin A zwitterion
 created_by: yaf
 creation_date: 2012-07-11T03:15:56Z
 
@@ -473023,7 +473023,7 @@ synonym: "bacitracin A breakdown" EXACT [GOC:TermGenie]
 synonym: "bacitracin A catabolism" EXACT [GOC:TermGenie]
 synonym: "bacitracin A degradation" EXACT [GOC:TermGenie]
 intersection_of: GO:0009056 ! catabolic process
-intersection_of: has_primary_input CHEBI:35862 ! bacitracin A
+intersection_of: has_primary_input CHEBI:184381 ! bacitracin A zwitterion
 created_by: yaf
 creation_date: 2012-07-11T03:16:20Z
 
@@ -473037,7 +473037,7 @@ synonym: "bacitracin A biosynthesis" EXACT [GOC:TermGenie]
 synonym: "bacitracin A formation" EXACT [GOC:TermGenie]
 synonym: "bacitracin A synthesis" EXACT [GOC:TermGenie]
 intersection_of: GO:0009058 ! biosynthetic process
-intersection_of: has_primary_output CHEBI:35862 ! bacitracin A
+intersection_of: has_primary_output CHEBI:184381 ! bacitracin A zwitterion
 created_by: yaf
 creation_date: 2012-07-11T03:16:27Z
 
@@ -529151,7 +529151,7 @@ name: response to kainic acid
 namespace: biological_process
 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a kainic acid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17443789]
 intersection_of: GO:0050896 ! response to stimulus
-intersection_of: has_input CHEBI:31746 ! kainic acid
+intersection_of: has_input CHEBI:156548 ! kainate(1-)
 created_by: sl
 creation_date: 2015-06-18T22:42:52Z
 
@@ -529161,7 +529161,7 @@ name: cellular response to kainic acid
 namespace: biological_process
 def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a kainic acid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17443789]
 intersection_of: GO:0070887 ! cellular response to chemical stimulus
-intersection_of: has_input CHEBI:31746 ! kainic acid
+intersection_of: has_input CHEBI:156548 ! kainate(1-)
 created_by: sl
 creation_date: 2015-06-18T22:42:58Z
 
diff --git a/src/ontology/imports/go-pattern-conformance.ttl b/src/ontology/imports/go-pattern-conformance.ttl
index 6d9516496a..2222ef5a7b 100644
--- a/src/ontology/imports/go-pattern-conformance.ttl
+++ b/src/ontology/imports/go-pattern-conformance.ttl
@@ -774,7 +774,7 @@
 <http://purl.obolibrary.org/obo/GO_0001890> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/x_development.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0001898> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
+<http://purl.obolibrary.org/obo/GO_0001898> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0001899> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
@@ -891,7 +891,7 @@
 <http://purl.obolibrary.org/obo/GO_0001968> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/macromolecular_complex_binding.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0001969> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
+<http://purl.obolibrary.org/obo/GO_0001969> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0001970> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
@@ -3846,6 +3846,9 @@
 <http://purl.obolibrary.org/obo/GO_0006309> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/involved_in_x_y.yaml> .
 # 
 
+<http://purl.obolibrary.org/obo/GO_0006325> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/cc_assembly.yaml> .
+# 
+
 <http://purl.obolibrary.org/obo/GO_0006334> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/cc_assembly.yaml> .
 # 
 
@@ -4650,7 +4653,7 @@
 <http://purl.obolibrary.org/obo/GO_0006933> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/involved_in_x_y.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0006937> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
+<http://purl.obolibrary.org/obo/GO_0006937> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0006939> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/occursIn.yaml> .
@@ -4875,7 +4878,7 @@
 <http://purl.obolibrary.org/obo/GO_0007315> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/cc_assembly.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0007317> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
+<http://purl.obolibrary.org/obo/GO_0007317> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0007346> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
@@ -7689,7 +7692,7 @@
 <http://purl.obolibrary.org/obo/GO_0010968> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0010969> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
+<http://purl.obolibrary.org/obo/GO_0010969> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0010971> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
@@ -12195,9 +12198,6 @@
 <http://purl.obolibrary.org/obo/GO_0031496> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0031497> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/cc_assembly.yaml> .
-# 
-
 <http://purl.obolibrary.org/obo/GO_0031498> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/cc_disassembly.yaml> .
 # 
 
@@ -12234,7 +12234,7 @@
 <http://purl.obolibrary.org/obo/GO_0031536> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0031537> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
+<http://purl.obolibrary.org/obo/GO_0031537> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0031538> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
@@ -13341,7 +13341,7 @@
 <http://purl.obolibrary.org/obo/GO_0032430> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0032434> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
+<http://purl.obolibrary.org/obo/GO_0032434> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0032435> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
@@ -13647,7 +13647,7 @@
 <http://purl.obolibrary.org/obo/GO_0032675> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0032676> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
+<http://purl.obolibrary.org/obo/GO_0032676> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0032677> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
@@ -17748,9 +17748,6 @@
 <http://purl.obolibrary.org/obo/GO_0042589> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/bounding_membrane_of_organelle.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0042616> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/metabolic_process.yaml> .
-# 
-
 <http://purl.obolibrary.org/obo/GO_0042617> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/biosynthetic_process.yaml> .
 # 
 
@@ -19665,7 +19662,7 @@
 <http://purl.obolibrary.org/obo/GO_0045345> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0045346> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
+<http://purl.obolibrary.org/obo/GO_0045346> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0045347> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
@@ -22056,7 +22053,7 @@
 <http://purl.obolibrary.org/obo/GO_0046604> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0046605> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
+<http://purl.obolibrary.org/obo/GO_0046605> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0046606> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
@@ -22155,7 +22152,7 @@
 <http://purl.obolibrary.org/obo/GO_0046657> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/catabolic_process.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0046658> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/anchored_membrane_component.yaml> , <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> .
+<http://purl.obolibrary.org/obo/GO_0046658> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> , <http://purl.obolibrary.org/obo/go/patterns/anchored_membrane_component.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0046662> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
@@ -25563,7 +25560,7 @@
 <http://purl.obolibrary.org/obo/GO_0060101> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0060123> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
+<http://purl.obolibrary.org/obo/GO_0060123> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0060124> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
@@ -25578,7 +25575,7 @@
 <http://purl.obolibrary.org/obo/GO_0060143> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0060147> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
+<http://purl.obolibrary.org/obo/GO_0060147> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0060148> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
@@ -25593,7 +25590,7 @@
 <http://purl.obolibrary.org/obo/GO_0060157> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/x_development.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0060159> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
+<http://purl.obolibrary.org/obo/GO_0060159> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0060160> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
@@ -28566,7 +28563,7 @@
 <http://purl.obolibrary.org/obo/GO_0070245> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0070247> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
+<http://purl.obolibrary.org/obo/GO_0070247> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0070248> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
@@ -30795,7 +30792,7 @@
 <http://purl.obolibrary.org/obo/GO_0075203> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0075215> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
+<http://purl.obolibrary.org/obo/GO_0075215> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0075216> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
@@ -30819,7 +30816,7 @@
 <http://purl.obolibrary.org/obo/GO_0075225> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0075227> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
+<http://purl.obolibrary.org/obo/GO_0075227> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0075228> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
@@ -30828,7 +30825,7 @@
 <http://purl.obolibrary.org/obo/GO_0075229> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0075240> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
+<http://purl.obolibrary.org/obo/GO_0075240> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0075241> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
@@ -30909,7 +30906,7 @@
 <http://purl.obolibrary.org/obo/GO_0075274> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0075276> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
+<http://purl.obolibrary.org/obo/GO_0075276> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0075277> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
@@ -31632,7 +31629,7 @@
 <http://purl.obolibrary.org/obo/GO_0090206> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0090207> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
+<http://purl.obolibrary.org/obo/GO_0090207> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0090208> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
@@ -32019,7 +32016,7 @@
 <http://purl.obolibrary.org/obo/GO_0090363> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0090364> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
+<http://purl.obolibrary.org/obo/GO_0090364> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0090365> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
@@ -32577,7 +32574,7 @@
 <http://purl.obolibrary.org/obo/GO_0098709> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/import_across_membrane.yaml> , <http://purl.obolibrary.org/obo/go/patterns/transmembrane_import_into_cytosol.yaml> , <http://purl.obolibrary.org/obo/go/patterns/import_across_plasma_membrane.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0098710> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/import_across_membrane.yaml> , <http://purl.obolibrary.org/obo/go/patterns/import_across_plasma_membrane.yaml> , <http://purl.obolibrary.org/obo/go/patterns/transmembrane_import_into_cytosol.yaml> .
+<http://purl.obolibrary.org/obo/GO_0098710> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/import_across_plasma_membrane.yaml> , <http://purl.obolibrary.org/obo/go/patterns/import_across_membrane.yaml> , <http://purl.obolibrary.org/obo/go/patterns/transmembrane_import_into_cytosol.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0098711> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/import_across_membrane.yaml> , <http://purl.obolibrary.org/obo/go/patterns/import_across_plasma_membrane.yaml> , <http://purl.obolibrary.org/obo/go/patterns/transmembrane_import_into_cytosol.yaml> .
@@ -32892,7 +32889,7 @@
 <http://purl.obolibrary.org/obo/GO_0099021> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0099025> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> , <http://purl.obolibrary.org/obo/go/patterns/anchored_membrane_component.yaml> .
+<http://purl.obolibrary.org/obo/GO_0099025> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/anchored_membrane_component.yaml> , <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0099026> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/anchored_membrane_component.yaml> , <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> .
@@ -32901,7 +32898,7 @@
 <http://purl.obolibrary.org/obo/GO_0099027> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> , <http://purl.obolibrary.org/obo/go/patterns/anchored_membrane_component.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0099028> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/anchored_membrane_component.yaml> , <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> .
+<http://purl.obolibrary.org/obo/GO_0099028> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> , <http://purl.obolibrary.org/obo/go/patterns/anchored_membrane_component.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0099029> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> , <http://purl.obolibrary.org/obo/go/patterns/anchored_membrane_component.yaml> .
@@ -32910,13 +32907,13 @@
 <http://purl.obolibrary.org/obo/GO_0099030> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> , <http://purl.obolibrary.org/obo/go/patterns/anchored_membrane_component.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0099031> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/anchored_membrane_component.yaml> , <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> .
+<http://purl.obolibrary.org/obo/GO_0099031> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> , <http://purl.obolibrary.org/obo/go/patterns/anchored_membrane_component.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0099032> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/anchored_membrane_component.yaml> , <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0099033> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/anchored_membrane_component.yaml> , <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> .
+<http://purl.obolibrary.org/obo/GO_0099033> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> , <http://purl.obolibrary.org/obo/go/patterns/anchored_membrane_component.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0099034> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/anchored_membrane_component.yaml> , <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> .
@@ -32925,10 +32922,10 @@
 <http://purl.obolibrary.org/obo/GO_0099035> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/anchored_membrane_component.yaml> , <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0099036> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> , <http://purl.obolibrary.org/obo/go/patterns/anchored_membrane_component.yaml> .
+<http://purl.obolibrary.org/obo/GO_0099036> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/anchored_membrane_component.yaml> , <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0099037> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> , <http://purl.obolibrary.org/obo/go/patterns/anchored_membrane_component.yaml> .
+<http://purl.obolibrary.org/obo/GO_0099037> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/anchored_membrane_component.yaml> , <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0099043> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/involved_in_x_y.yaml> .
@@ -33006,7 +33003,7 @@
 <http://purl.obolibrary.org/obo/GO_0099143> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0099144> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/anchored_membrane_component.yaml> , <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> .
+<http://purl.obolibrary.org/obo/GO_0099144> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/part_of_cell_component.yaml> , <http://purl.obolibrary.org/obo/go/patterns/anchored_membrane_component.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0099145> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
@@ -34158,7 +34155,7 @@
 <http://purl.obolibrary.org/obo/GO_0140124> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_0140125> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/import_across_plasma_membrane.yaml> , <http://purl.obolibrary.org/obo/go/patterns/import_across_membrane.yaml> , <http://purl.obolibrary.org/obo/go/patterns/transmembrane_import_into_cytosol.yaml> .
+<http://purl.obolibrary.org/obo/GO_0140125> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/import_across_membrane.yaml> , <http://purl.obolibrary.org/obo/go/patterns/import_across_plasma_membrane.yaml> , <http://purl.obolibrary.org/obo/go/patterns/transmembrane_import_into_cytosol.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_0140131> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
@@ -35712,7 +35709,7 @@
 <http://purl.obolibrary.org/obo/GO_1900359> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1900360> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
+<http://purl.obolibrary.org/obo/GO_1900360> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_1900361> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
@@ -35772,7 +35769,7 @@
 <http://purl.obolibrary.org/obo/GO_1900381> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1900384> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
+<http://purl.obolibrary.org/obo/GO_1900384> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_1900385> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
@@ -35835,7 +35832,7 @@
 <http://purl.obolibrary.org/obo/GO_1900430> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1900431> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
+<http://purl.obolibrary.org/obo/GO_1900431> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_1900432> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
@@ -36543,7 +36540,7 @@
 <http://purl.obolibrary.org/obo/GO_1900706> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1900707> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
+<http://purl.obolibrary.org/obo/GO_1900707> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_1900708> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
@@ -36729,24 +36726,15 @@
 <http://purl.obolibrary.org/obo/GO_1900769> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/biosynthetic_process.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1900770> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/metabolic_process.yaml> .
-# 
-
 <http://purl.obolibrary.org/obo/GO_1900771> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/catabolic_process.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_1900772> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/biosynthetic_process.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1900773> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/metabolic_process.yaml> .
-# 
-
 <http://purl.obolibrary.org/obo/GO_1900774> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/catabolic_process.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1900775> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/biosynthetic_process.yaml> .
-# 
-
 <http://purl.obolibrary.org/obo/GO_1900776> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/metabolic_process.yaml> .
 # 
 
@@ -36756,9 +36744,6 @@
 <http://purl.obolibrary.org/obo/GO_1900778> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/biosynthetic_process.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1900779> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/metabolic_process.yaml> .
-# 
-
 <http://purl.obolibrary.org/obo/GO_1900780> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/catabolic_process.yaml> .
 # 
 
@@ -36801,9 +36786,6 @@
 <http://purl.obolibrary.org/obo/GO_1900793> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/biosynthetic_process.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1900794> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/metabolic_process.yaml> .
-# 
-
 <http://purl.obolibrary.org/obo/GO_1900795> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/catabolic_process.yaml> .
 # 
 
@@ -36828,9 +36810,6 @@
 <http://purl.obolibrary.org/obo/GO_1900802> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/biosynthetic_process.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1900803> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/metabolic_process.yaml> .
-# 
-
 <http://purl.obolibrary.org/obo/GO_1900804> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/catabolic_process.yaml> .
 # 
 
@@ -36840,9 +36819,6 @@
 <http://purl.obolibrary.org/obo/GO_1900806> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/catabolic_process.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1900807> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/metabolic_process.yaml> .
-# 
-
 <http://purl.obolibrary.org/obo/GO_1900808> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/catabolic_process.yaml> .
 # 
 
@@ -36972,9 +36948,6 @@
 <http://purl.obolibrary.org/obo/GO_1900851> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1900852> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
-# 
-
 <http://purl.obolibrary.org/obo/GO_1900853> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
 # 
 
@@ -37365,18 +37338,12 @@
 <http://purl.obolibrary.org/obo/GO_1900985> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/biosynthetic_process.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1900986> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/metabolic_process.yaml> .
-# 
-
 <http://purl.obolibrary.org/obo/GO_1900987> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/catabolic_process.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_1900988> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/biosynthetic_process.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1900989> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/metabolic_process.yaml> .
-# 
-
 <http://purl.obolibrary.org/obo/GO_1900990> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/catabolic_process.yaml> .
 # 
 
@@ -37446,9 +37413,6 @@
 <http://purl.obolibrary.org/obo/GO_1901012> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/biosynthetic_process.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1901013> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/metabolic_process.yaml> .
-# 
-
 <http://purl.obolibrary.org/obo/GO_1901014> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/catabolic_process.yaml> .
 # 
 
@@ -37545,9 +37509,6 @@
 <http://purl.obolibrary.org/obo/GO_1901048> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/involved_in_x_y.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1901049> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/metabolic_process.yaml> .
-# 
-
 <http://purl.obolibrary.org/obo/GO_1901050> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/catabolic_process.yaml> .
 # 
 
@@ -38427,7 +38388,7 @@
 <http://purl.obolibrary.org/obo/GO_1901387> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1901388> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
+<http://purl.obolibrary.org/obo/GO_1901388> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_1901389> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
@@ -39846,7 +39807,7 @@
 <http://purl.obolibrary.org/obo/GO_1901953> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1901954> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
+<http://purl.obolibrary.org/obo/GO_1901954> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_1901955> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
@@ -41169,7 +41130,7 @@
 <http://purl.obolibrary.org/obo/GO_1902512> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1902513> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
+<http://purl.obolibrary.org/obo/GO_1902513> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_1902514> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
@@ -41775,7 +41736,7 @@
 <http://purl.obolibrary.org/obo/GO_1902836> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1902838> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
+<http://purl.obolibrary.org/obo/GO_1902838> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_1902839> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
@@ -41838,7 +41799,7 @@
 <http://purl.obolibrary.org/obo/GO_1902860> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/biosynthetic_process.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1902863> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
+<http://purl.obolibrary.org/obo/GO_1902863> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_1902864> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
@@ -43635,7 +43596,7 @@
 <http://purl.obolibrary.org/obo/GO_1903592> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1903593> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
+<http://purl.obolibrary.org/obo/GO_1903593> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_1903594> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
@@ -44628,7 +44589,7 @@
 <http://purl.obolibrary.org/obo/GO_1904018> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1904020> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
+<http://purl.obolibrary.org/obo/GO_1904020> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_1904021> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
@@ -44943,7 +44904,7 @@
 <http://purl.obolibrary.org/obo/GO_1904151> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1904152> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
+<http://purl.obolibrary.org/obo/GO_1904152> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_1904153> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
@@ -47910,7 +47871,7 @@
 <http://purl.obolibrary.org/obo/GO_1905434> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1905435> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
+<http://purl.obolibrary.org/obo/GO_1905435> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_1905436> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
@@ -48126,7 +48087,7 @@
 <http://purl.obolibrary.org/obo/GO_1905516> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_1905518> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
+<http://purl.obolibrary.org/obo/GO_1905518> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_1905519> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
@@ -51639,7 +51600,7 @@
 <http://purl.obolibrary.org/obo/GO_2000793> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/involved_in_x_y.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_2000794> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
+<http://purl.obolibrary.org/obo/GO_2000794> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_2000795> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
@@ -52851,7 +52812,7 @@
 <http://purl.obolibrary.org/obo/GO_2001232> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_2001233> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
+<http://purl.obolibrary.org/obo/GO_2001233> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_2001234> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
@@ -52887,7 +52848,7 @@
 <http://purl.obolibrary.org/obo/GO_2001244> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
 # 
 
-<http://purl.obolibrary.org/obo/GO_2001245> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> .
+<http://purl.obolibrary.org/obo/GO_2001245> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> , <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
 # 
 
 <http://purl.obolibrary.org/obo/GO_2001246> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .