From 5119df78a73943b2d0c8b63c72ab6cd573c3a422 Mon Sep 17 00:00:00 2001 From: Jim Balhoff Date: Wed, 6 Nov 2024 12:29:02 -0500 Subject: [PATCH] Copy enzyme defxrefs to xrefs. --- src/ontology/go-edit.obo | 311 ++++++++++++++++++++++++++++++++++++++- 1 file changed, 306 insertions(+), 5 deletions(-) diff --git a/src/ontology/go-edit.obo b/src/ontology/go-edit.obo index 9f3497fc69..cf0d12f291 100644 --- a/src/ontology/go-edit.obo +++ b/src/ontology/go-edit.obo @@ -103,6 +103,7 @@ namespace: molecular_function def: "Enables the transfer of zinc ions (Zn2+) from one side of a membrane to the other, probably powered by proton motive force. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.5.1.1] synonym: "high affinity zinc uptake transmembrane transporter activity" EXACT [] synonym: "high-affinity zinc uptake transmembrane transporter activity" RELATED [] +xref: TC:2.A.5.1.1 is_a: GO:0005385 ! zinc ion transmembrane transporter activity [Term] @@ -40263,6 +40264,7 @@ comment: Histone deacytylase (HDAC) enzymes are divided into four classes: the C synonym: "histone deacetylase activity (NAD-independent)" EXACT [] xref: EC:2.3.1.- {source="skos:broadMatch"} xref: EC:3.5.1.- {source="skos:broadMatch"} +xref: RHEA:58196 is_a: GO:0033558 ! protein lysine deacetylase activity property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22295" xsd:anyURI @@ -45906,6 +45908,8 @@ name: sulfate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate." [GOC:mah, MetaCyc:SULFATE-ADENYLYLTRANS-RXN, MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN] synonym: "sulphate adenylyltransferase activity" EXACT [] +xref: MetaCyc:SULFATE-ADENYLYLTRANS-RXN +xref: MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN is_a: GO:0070566 ! adenylyltransferase activity [Term] @@ -51087,6 +51091,7 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "allantoin permease activity" RELATED [] synonym: "allantoin uptake transmembrane transporter activity" NARROW [] synonym: "allantoin/allantoate transporter" BROAD [] +xref: TC:2.A.39.3.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:15676 ! allantoin @@ -51130,6 +51135,7 @@ name: acetylcholine:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out)." [TC:2.A.1.2.13] synonym: "acetylcholine:hydrogen antiporter activity" EXACT [] +xref: TC:2.A.1.2.13 intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:15355 ! acetylcholine intersection_of: has_primary_input CHEBI:15378 ! hydron @@ -51248,6 +51254,7 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "neutral amino acid-sodium cotransporter" BROAD [] synonym: "neutral amino acid:sodium symporter activity" EXACT [] synonym: "sodium/neutral amino acid transporter" BROAD [] +xref: TC:2.A.23.3.1 is_a: GO:0005283 ! amino acid:sodium symporter activity is_a: GO:0015175 ! neutral L-amino acid transmembrane transporter activity @@ -51269,6 +51276,7 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "sodium/proline symporter activity" EXACT [] xref: MetaCyc:TRANS-RXN-118 xref: RHEA:28967 +xref: TC:2.A.22.2.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:26271 ! proline intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) @@ -51331,6 +51339,7 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in)." [TC:2.A.22.3.5] synonym: "sodium/choline symporter activity" EXACT [] xref: RHEA:76443 +xref: TC:2.A.22.3.5 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15354 ! choline intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) @@ -51351,6 +51360,7 @@ name: creatine:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in)." [TC:2.A.22.3.4] synonym: "sodium/chloride-dependent creatine transporter" BROAD [] +xref: TC:2.A.22.3.4 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) intersection_of: has_primary_input CHEBI:57947 ! creatine zwitterion @@ -51405,6 +51415,7 @@ namespace: molecular_function def: "Enables the transfer of glutamate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.3.10.5] synonym: "high-affinity glutamate transmembrane transporter activity" BROAD [] synonym: "high-affinity glutamate transporter activity" BROAD [] +xref: TC:2.A.3.10.5 is_a: GO:0005313 ! L-glutamate transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27521" xsd:anyURI @@ -51431,6 +51442,7 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "high affinity inorganic phosphate:sodium symporter activity" EXACT [] synonym: "high-affinity inorganic phosphate:sodium symporter activity" EXACT [] synonym: "sodium/phosphate cotransporter activity" BROAD [] +xref: TC:2.A.20.2.2 is_a: GO:0005436 ! sodium:phosphate symporter activity is_a: GO:0015370 ! solute:sodium symporter activity @@ -51533,6 +51545,7 @@ name: neurotransmitter:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-] synonym: "sodium/neurotransmitter symporter activity" EXACT [] +xref: TC:2.A.22.-.- intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) intersection_of: has_primary_input GOCHE:25512 ! substance with neurotransmitter role @@ -51548,6 +51561,7 @@ synonym: "dopamine:sodium:chloride symporter activity" EXACT [] synonym: "sodium/dopamine symporter activity" EXACT [] xref: RHEA:70919 {source="skos:narrowMatch"} xref: RHEA:70931 {source="skos:narrowMatch"} +xref: TC:2.A.22.1.3 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:17996 ! chloride intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) @@ -51589,6 +51603,7 @@ synonym: "noradrenaline transporter activity" EXACT [] synonym: "norepinephrine transmembrane transporter activity" EXACT [] synonym: "norepinephrine:sodium:chloride symporter activity" EXACT [] synonym: "sodium/norepinephrine symporter activity" EXACT [] +xref: TC:2.A.22.1.2 xref: Wikipedia:Norepinephrine_transporter intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:17996 ! chloride @@ -51661,6 +51676,7 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in)." [TC:2.A.28.1.1] synonym: "sodium/chloride-dependent organic acid cotransporter activity" RELATED [] synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW [] +xref: TC:2.A.28.1.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) intersection_of: has_primary_input CHEBI:64709 ! organic acid @@ -51754,6 +51770,7 @@ synonym: "alpha-glucoside:hydrogen symporter activity" EXACT [] synonym: "general alpha-glucoside transporter activity" BROAD [] synonym: "general alpha-glucoside:hydrogen symporter activity" EXACT [] synonym: "general alpha-glucoside:proton symporter activity" EXACT [] +xref: TC:2.A.1.1.11 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:60979 ! alpha-glucoside @@ -51865,6 +51882,7 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose(out) + Na+(out) = D-glucose(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.21.3.-] synonym: "low-affinity glucose-sodium cotransporter activity" BROAD [] synonym: "low-affinity glucose:sodium symporter activity" EXACT [] +xref: TC:2.A.21.3.- is_a: GO:0005412 ! D-glucose:sodium symporter activity [Term] @@ -51887,6 +51905,7 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "hydrogen/maltose transporter activity" BROAD [] synonym: "maltose permease" BROAD [] synonym: "maltose:hydrogen symporter activity" EXACT [] +xref: TC:2.A.1.1.10 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:17306 ! maltose @@ -51909,6 +51928,7 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "hydrogen/myo-inositol transporter activity" BROAD [] synonym: "myo-inositol:hydrogen symporter activity" EXACT [] xref: RHEA:60364 +xref: TC:2.A.1.1.8 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:17268 ! myo-inositol @@ -51919,6 +51939,7 @@ name: myo-inositol:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in)." [TC:2.A.21.4.-] synonym: "myo-inositol-sodium cotransporter activity" BROAD [] +xref: TC:2.A.21.4.- intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:17268 ! myo-inositol intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) @@ -51939,6 +51960,7 @@ name: taurine:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in)." [TC:2.A.22.3.3] synonym: "sodium/chloride-dependent taurine transporter" BROAD [] +xref: TC:2.A.22.3.3 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) intersection_of: has_primary_input CHEBI:507393 ! taurine zwitterion @@ -52170,6 +52192,7 @@ synonym: "sodium/glucose symporter activity" EXACT [] xref: MetaCyc:RXN-22596 xref: RHEA:70495 {source="skos:narrowMatch"} xref: RHEA:70571 {source="skos:narrowMatch"} +xref: TC:2.A.21.3.- intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) intersection_of: has_primary_input CHEBI:4167 ! D-glucopyranose @@ -52382,6 +52405,7 @@ name: succinate:fumarate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out)." [TC:2.A.29.13.1] xref: RHEA:29323 +xref: TC:2.A.29.13.1 intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:29806 ! fumarate(2-) intersection_of: has_primary_input CHEBI:30031 ! succinate(2-) @@ -52399,6 +52423,7 @@ synonym: "ADP/ATP translocase" EXACT [] synonym: "ATP/ADP exchange" EXACT [] synonym: "ATP/ADP exchanger" EXACT [] xref: RHEA:34999 +xref: TC:2.A.29.1.1 intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:30616 ! ATP(4-) intersection_of: has_primary_input CHEBI:456216 ! ADP(3-) @@ -57055,6 +57080,7 @@ synonym: "glycine decarboxylase complex" EXACT [] synonym: "glycine dehydrogenase (decarboxylating) complex" EXACT [] synonym: "glycine dehydrogenase complex (decarboxylating)" RELATED [] synonym: "glycine synthase complex" EXACT [] +xref: MetaCyc:GCVMULTI-CPLX xref: Wikipedia:Glycine_decarboxylase_complex intersection_of: GO:1902494 ! catalytic complex intersection_of: capable_of GO:0004375 ! glycine dehydrogenase (decarboxylating) activity @@ -58834,6 +58860,7 @@ name: fermentation namespace: biological_process def: "The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, coupling the oxidation and reduction of NAD/H and the generation of adenosine triphosphate (ATP)." [GOC:curators, ISBN:0201090910, MetaCyc:Fermentation] subset: goslim_pir +xref: MetaCyc:Fermentation xref: MetaCyc:FERMENTATION-PWY xref: Wikipedia:Fermentation_(biochemistry) is_a: GO:0015980 ! energy derivation by oxidation of organic compounds @@ -63928,6 +63955,8 @@ synonym: "creatine anabolism" EXACT [] synonym: "creatine biosynthesis" EXACT [] synonym: "creatine formation" EXACT [] synonym: "creatine synthesis" EXACT [] +xref: MetaCyc:GLYCGREAT-PWY +xref: MetaCyc:PWY-6158 intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:57947 ! creatine zwitterion @@ -64756,6 +64785,7 @@ synonym: "mannose-inositol-P-ceramide (MIPC) metabolism" EXACT [] synonym: "mannosyl-inositol-phosphorylceramide metabolism" EXACT [] synonym: "MIPC metabolic process" EXACT [] synonym: "MIPC metabolism" EXACT [] +xref: MetaCyc:MIPC intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:64997 ! mannosylinositol phosphorylceramide(1-) @@ -76033,6 +76063,7 @@ synonym: "para-aminobenzoic acid formation" EXACT [] synonym: "para-aminobenzoic acid synthesis" EXACT [] synonym: "vitamin Bx biosynthesis" EXACT [] synonym: "vitamin Bx biosynthetic process" EXACT [] +xref: MetaCyc:PWY-6543 intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:17836 ! 4-aminobenzoate @@ -77232,6 +77263,7 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in)." [TC:2.A.19.4.1] synonym: "potassium-dependent sodium/calcium exchanger" RELATED [] xref: RHEA:69967 +xref: TC:2.A.19.4.1 intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) intersection_of: has_primary_input CHEBI:29103 ! potassium(1+) @@ -79355,7 +79387,6 @@ name: histone arginine N-methyltransferase activity namespace: molecular_function alt_id: GO:0016276 def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine." [PMID:8002954] -synonym: "histone-arginine N-methylase activity" EXACT [] synonym: "histone-arginine N-methylase activity" EXACT [GOC:mah] synonym: "histone-arginine N-methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:histone-arginine nomega-methyltransferase activity" EXACT [] @@ -79812,6 +79843,7 @@ synonym: "hydrogen/sucrose transporter activity" BROAD [] synonym: "sucrose:hydrogen symporter activity" EXACT [] xref: MetaCyc:TRANS-RXN-244 xref: RHEA:72187 +xref: TC:2.A.1.5.3 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:17992 ! sucrose @@ -79823,6 +79855,7 @@ name: sodium:iodide symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in)." [TC:2.A.21.5.1] synonym: "sodium/iodide symporter activity" EXACT [] +xref: TC:2.A.21.5.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:16382 ! iodide intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) @@ -79833,6 +79866,7 @@ name: bile acid:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in)." [TC:2.A.28.-.-] synonym: "sodium/bile acid symporter activity" EXACT [] +xref: TC:2.A.28.-.- intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) intersection_of: has_primary_input CHEBI:3098 ! bile acid @@ -79858,6 +79892,7 @@ synonym: "sodium/bicarbonate cotransporter activity" BROAD [] synonym: "sodium:bicarbonate cotransporter activity" BROAD [] synonym: "sodium:hydrogencarbonate symporter activity" EXACT [] xref: RHEA:70267 +xref: TC:2.A.31.2.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:17544 ! hydrogencarbonate intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) @@ -79871,6 +79906,7 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in)." [TC:2.A.30.1.1] synonym: "sodium/potassium/chloride symporter activity" EXACT [] xref: RHEA:72395 +xref: TC:2.A.30.1.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:17996 ! chloride intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) @@ -79886,6 +79922,7 @@ synonym: "sulfate/hydrogen symporter activity" EXACT [] synonym: "sulfate:hydrogen symporter activity" EXACT [] synonym: "sulphate:hydrogen symporter activity" EXACT [] xref: RHEA:28574 +xref: TC:2.A.53.-.- intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:16189 ! sulfate @@ -79928,6 +79965,7 @@ id: GO:0008516 name: hexose uniporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) = hexose(in)." [TC:2.A.1.1.5] +xref: TC:2.A.1.1.5 is_a: GO:0015149 ! hexose transmembrane transporter activity is_a: GO:0015292 ! uniporter activity @@ -80013,6 +80051,7 @@ id: GO:0008523 name: sodium-dependent multivitamin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate." [TC:2.A.21.5.2] +xref: TC:2.A.21.5.2 is_a: GO:0015370 ! solute:sodium symporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity @@ -81904,6 +81943,7 @@ synonym: "HcaA1A2CD" RELATED [EC:1.14.12.19] xref: EC:1.14.12.19 xref: MetaCyc:HCAMULTI-RXN xref: RHEA:20357 +xref: UM-BBD_enzymeID:e0307 xref: UM-BBD_enzymeID:r0434 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor @@ -90655,6 +90695,7 @@ name: dimethyl sulfoxide reductase complex namespace: cellular_component def: "An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide." [UM-BBD_enzymeID:r0207] synonym: "dimethyl sulphoxide reductase complex" EXACT [] +xref: UM-BBD_enzymeID:r0207 is_a: GO:0032991 ! protein-containing complex [Term] @@ -93386,6 +93427,8 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "sucrose permease activity" RELATED [] synonym: "sucrose:cation symporter activity" BROAD [] synonym: "sucrose:monovalent cation symporter activity" EXACT [] +xref: TC:2.A.2.-.- +xref: TC:2.A.2.4.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:17992 ! sucrose intersection_of: has_primary_input CHEBI:23906 ! monoatomic cation @@ -93401,6 +93444,7 @@ synonym: "dihydroxyacetone phosphate:phosphate antiporter activity" EXACT [] synonym: "TPT" RELATED [] synonym: "triose phosphate antiporter" EXACT [] synonym: "triose phosphate translocator" EXACT [] +xref: TC:2.A.7.-.- intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:35142 ! aldotriose phosphate intersection_of: has_primary_input CHEBI:43474 ! hydrogenphosphate @@ -93435,6 +93479,7 @@ name: low-affinity phosphate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of phosphate from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.20.-.-] synonym: "low affinity phosphate transmembrane transporter activity" EXACT [] +xref: TC:2.A.20.-.- is_a: GO:0005315 ! phosphate transmembrane transporter activity [Term] @@ -93443,6 +93488,7 @@ name: potassium:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Na+(out) = K+(in) + Na+(in)." [TC:2.A.38.3.1] synonym: "high affinity potassium transporter" RELATED [] +xref: TC:2.A.38.3.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) intersection_of: has_primary_input CHEBI:29103 ! potassium(1+) @@ -93501,6 +93547,7 @@ name: hexose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) + H+(out) = hexose(in) + H+(in)." [TC:2.A.1.-.-] synonym: "hexose:hydrogen symporter activity" EXACT [] +xref: TC:2.A.1.-.- intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:18133 ! hexose @@ -98142,6 +98189,7 @@ name: sulfate assimilation via adenylyl sulfate reduction namespace: biological_process def: "The pathway by which inorganic sulfate is activated, reduced and incorporated into sulfated compounds, where the activated sulfate, adenylyl-sulfate, is reduced to sulfite by the activity of adenylyl-sulfate reductase." [EC:1.8.99.2] synonym: "sulphate assimilation via adenylyl sulphate reduction" EXACT [] +xref: EC:1.8.99.2 xref: MetaCyc:SULFMETII-PWY intersection_of: GO:0000103 ! sulfate assimilation intersection_of: has_part GO:0009973 ! adenylyl-sulfate reductase activity @@ -99661,6 +99709,7 @@ namespace: molecular_function alt_id: GO:0042411 def: "Catalysis of the reaction: a carotene + a reduced electron acceptor + O2 = C3-hydroxylated carotene + an oxidized electron acceptor + H2O. This is a general reaction to represent the C3 hydroxylation of the beta ring of a carotene." [MetaCyc:MONOMER-12386, PMID:16492736] synonym: "beta-carotene hydroxylase activity" NARROW [] +xref: MetaCyc:MONOMER-12386 is_a: GO:0004497 ! monooxygenase activity property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/5604" xsd:anyURI @@ -109451,6 +109500,7 @@ namespace: molecular_function def: "Enables the transfer of a copper ions (Cu2+) from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:9.A.11.1.1] synonym: "high affinity copper ion transmembrane transporter activity" EXACT [] synonym: "high affinity copper transporter activity" EXACT [] +xref: TC:9.A.11.1.1 is_a: GO:0005375 ! copper ion transmembrane transporter activity [Term] @@ -109460,6 +109510,7 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) = Fe2+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:9.A.9.1.1] synonym: "low affinity iron ion transmembrane transporter activity" EXACT [] synonym: "low affinity iron transporter activity" EXACT [] +xref: TC:9.A.9.1.1 is_a: GO:0015091 ! ferric iron transmembrane transporter activity relationship: part_of GO:0034755 ! iron ion transmembrane transport @@ -111221,6 +111272,7 @@ name: fructose uniporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose(out) = fructose(in)." [TC:2.A.1.1.13] xref: RHEA:60372 {source="skos:broadMatch"} +xref: TC:2.A.1.1.13 is_a: GO:0008516 ! hexose uniporter activity intersection_of: GO:0015292 ! uniporter activity intersection_of: has_primary_input CHEBI:28757 ! fructose @@ -111233,6 +111285,7 @@ namespace: molecular_function def: "Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820, TC:1.B.1.-.-] synonym: "outer membrane exporter porin" NARROW [] synonym: "porin" EXACT [] +xref: TC:1.B.1.-.- xref: Wikipedia:Porin_(protein) is_a: GO:0022829 ! wide pore channel activity @@ -111326,6 +111379,7 @@ name: monoatomic anion:monoatomic cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in)." [TC:2.A.1.14.-] synonym: "anion:cation symporter activity" BROAD [] +xref: TC:2.A.1.14.- intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:23905 ! monoatomic anion intersection_of: has_primary_input CHEBI:23906 ! monoatomic cation @@ -111404,6 +111458,9 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "galactose, glucose uniporter activity" NARROW [] synonym: "glucose uniporter activity" EXACT [] xref: RHEA:60376 {source="skos:broadMatch"} +xref: TC:2.A.1.1.12 +xref: TC:2.A.1.1.4 +xref: TC:2.A.1.1.6 is_a: GO:0008516 ! hexose uniporter activity intersection_of: GO:0015292 ! uniporter activity intersection_of: has_primary_input CHEBI:4167 ! D-glucopyranose @@ -111432,6 +111489,7 @@ synonym: "cation:sialate symporter activity" EXACT [] synonym: "sialate transporter activity" BROAD [] synonym: "sialate/cation symporter activity" EXACT [] synonym: "sialate:cation symporter activity" BROAD [] +xref: TC:2.A.1.14.10 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:23906 ! monoatomic cation intersection_of: has_primary_input CHEBI:35418 ! N-acetylneuraminate @@ -111463,6 +111521,7 @@ name: cycloheximide:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + cycloheximide(in) = H+(in) + cycloheximide(out)." [TC:2.A.1.2.2] synonym: "cycloheximide:hydrogen antiporter activity" EXACT [] +xref: TC:2.A.1.2.2 intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:27641 ! cycloheximide @@ -111473,6 +111532,7 @@ name: benomyl:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + benomyl(in) = H+(in) + benomyl(out)." [TC:2.A.1.2.6] synonym: "benomyl:hydrogen antiporter activity" EXACT [] +xref: TC:2.A.1.2.6 intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:3015 ! benomyl @@ -111483,6 +111543,8 @@ name: monoamine:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out)." [TC:2.A.1.2.11, TC:2.A.1.2.12] synonym: "monoamine:hydrogen antiporter activity" EXACT [] +xref: TC:2.A.1.2.11 +xref: TC:2.A.1.2.12 intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:63534 ! monoamine @@ -111493,6 +111555,7 @@ name: polyamine:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + polyamine(in) = H+(in) + polyamine(out)." [TC:2.A.1.2.16] synonym: "polyamine:hydrogen antiporter activity" EXACT [] +xref: TC:2.A.1.2.16 intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:51349 ! polyamine macromolecule @@ -111503,6 +111566,7 @@ name: fluconazole:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + fluconazole(in) = H+(in) + fluconazole(out)." [TC:2.A.1.2.17] synonym: "fluconazole:hydrogen antiporter activity" EXACT [] +xref: TC:2.A.1.2.17 intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:46081 ! fluconazole @@ -111513,6 +111577,7 @@ name: aminotriazole:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + aminotriazole(in) = H+(in) + aminotriazole(out)." [TC:2.A.1.3.1] synonym: "aminotriazole:hydrogen antiporter activity" EXACT [] +xref: TC:2.A.1.3.1 intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:40036 ! amitrole @@ -111523,6 +111588,7 @@ name: organophosphate:phosphate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organophosphate(out) + phosphate(in) = organophosphate(in) + phosphate(out)." [TC:2.A.1.4.-] synonym: "organophosphate:inorganic phosphate antiporter activity" EXACT [] +xref: TC:2.A.1.4.- intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:25710 ! organophosphorus compound intersection_of: has_primary_input CHEBI:43474 ! hydrogenphosphate @@ -111547,6 +111613,7 @@ alt_id: GO:0015320 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in)." [TC:2.A.1.9.-] synonym: "phosphate ion carrier activity" EXACT [] synonym: "phosphate:hydrogen symporter activity" EXACT [] +xref: TC:2.A.1.9.- intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:26020 ! phosphate @@ -111610,6 +111677,7 @@ id: GO:0015325 name: acetyl-CoA:CoA antiporter activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA(out) + CoA(in) = acetyl-CoA(in) + CoA(out)." [TC:2.A.1.25.1] +xref: TC:2.A.1.25.1 intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:57287 ! coenzyme A(4-) intersection_of: has_primary_input CHEBI:57288 ! acetyl-CoA(4-) @@ -111619,6 +111687,7 @@ id: GO:0015327 name: cystine:glutamate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out)." [TC:2.A.3.8.5] +xref: TC:2.A.3.8.5 is_a: GO:0005313 ! L-glutamate transmembrane transporter activity intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:14321 ! glutamate(1-) @@ -111679,6 +111748,7 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "peptide:hydrogen symporter activity" EXACT [] xref: MetaCyc:RXN-14653 {source="skos:narrowMatch"} xref: RHEA:37047 {source="skos:narrowMatch"} +xref: TC:2.A.17.-.- intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:60466 ! peptide zwitterion @@ -111755,6 +111825,8 @@ name: zinc efflux active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane: Zn2+(out) = Zn2+(in). The activity is driven by proton motive force." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.4.1.4, TC:2.A.4.2.3] synonym: "zinc efflux permease activity" BROAD [] +xref: TC:2.A.4.1.4 +xref: TC:2.A.4.2.3 is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0022883 ! zinc efflux transmembrane transporter activity @@ -111807,6 +111879,7 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "ferrioxamine uptake transmembrane transporter activity" RELATED [] synonym: "siderochrome-iron (ferrioxamine) uptake transporter" NARROW [] synonym: "siderophore-iron uptake transmembrane transporter activity" RELATED [] +xref: TC:2.A.1.16.1 is_a: GO:0015343 ! siderophore-iron transmembrane transporter activity [Term] @@ -111816,6 +111889,7 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric enterobactin(out) + H+(out) = ferric enterobactin(in) + H+(in)." [TC:2.A.1.16.2] synonym: "ferric enterobactin:hydrogen symporter activity" EXACT [] synonym: "ferric-enterobactin:proton symporter activity" EXACT [] +xref: TC:2.A.1.16.2 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:28199 ! ferrienterobactin(3-) @@ -111826,6 +111900,7 @@ name: ferric triacetylfusarinine C:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric triacetylfusarinine C(out) + H+(out) = ferric triacetylfusarinine C(in) + H+(in)." [TC:2.A.1.16.3] synonym: "ferric triacetylfusarinine C:hydrogen symporter activity" EXACT [] +xref: TC:2.A.1.16.3 is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0015343 ! siderophore-iron transmembrane transporter activity is_a: GO:0015621 ! ferric triacetylfusarinine C transmembrane transporter activity @@ -111932,6 +112007,7 @@ alt_id: GO:0015357 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: acetate(out) + H+(out) = acetate(in) + H+(in)." [TC:2.A.44.4.1] synonym: "acetate:hydrogen symporter activity" EXACT [] synonym: "hydrogen:acetate symporter activity" EXACT [] +xref: TC:2.A.44.4.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:30089 ! acetate @@ -111943,6 +112019,7 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.47.1.1] synonym: "low affinity sodium:dicarboxylate cotransporter activity" BROAD [] synonym: "low affinity sodium:dicarboxylate symporter activity" EXACT [] +xref: TC:2.A.47.1.1 is_a: GO:0017153 ! sodium:dicarboxylate symporter activity [Term] @@ -111952,6 +112029,7 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.47.1.4] synonym: "high affinity sodium:dicarboxylate cotransporter activity" BROAD [] synonym: "high affinity sodium:dicarboxylate symporter activity" EXACT [] +xref: TC:2.A.47.1.4 is_a: GO:0017153 ! sodium:dicarboxylate symporter activity [Term] @@ -111974,6 +112052,7 @@ name: dicarboxylate:phosphate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + phosphate(in) = dicarboxylate(in) + phosphate(out)." [TC:2.A.29.2.3] synonym: "dicarboxylate:inorganic phosphate antiporter activity" EXACT [] +xref: TC:2.A.29.2.3 intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:35692 ! dicarboxylic acid intersection_of: has_primary_input CHEBI:43474 ! hydrogenphosphate @@ -111989,6 +112068,7 @@ synonym: "malate permease" RELATED [GOC:vw] synonym: "malate:hydrogen symporter activity" EXACT [] xref: RHEA:28715 {source="skos:narrowMatch"} xref: RHEA:29339 {source="skos:narrowMatch"} +xref: TC:2.A.16.2.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:15595 ! malate(2-) @@ -112001,6 +112081,7 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out)." [TC:2.A.29.2.1] synonym: "2-oxoglutarate/malate carrier protein" EXACT [Wikipedia:Mitochondrial_carrier] xref: RHEA:71587 {source="skos:narrowMatch"} +xref: TC:2.A.29.2.1 intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:15595 ! malate(2-) intersection_of: has_primary_input CHEBI:16810 ! 2-oxoglutarate(2-) @@ -112013,6 +112094,7 @@ name: calcium:monoatomic cation antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in)." [TC:2.A.19.-.-] synonym: "calcium:cation antiporter activity" BROAD [] +xref: TC:2.A.19.-.- intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:23906 ! monoatomic cation intersection_of: has_primary_input CHEBI:29108 ! calcium(2+) @@ -112024,6 +112106,7 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in)." [RHEA:71799, TC:2.A.19.2.-] synonym: "calcium:hydrogen antiporter activity" EXACT [] xref: RHEA:71799 +xref: TC:2.A.19.2.- intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:29108 ! calcium(2+) @@ -112043,6 +112126,7 @@ id: GO:0015371 name: galactose:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + Na+(out) = glucose(in) + Na+(in)." [TC:2.A.21.3.-] +xref: TC:2.A.21.3.- intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:28260 ! galactose intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) @@ -112066,6 +112150,7 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic anion(out) + Na+(out) = monoatomic anion(in) + Na+(in)." [TC:2.A.21.5.-] synonym: "anion:sodium symporter activity" BROAD [] synonym: "monovalent anion:sodium symporter activity" RELATED [] +xref: TC:2.A.21.5.- intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:23905 ! monoatomic anion intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) @@ -112076,6 +112161,7 @@ name: neutral, basic amino acid:sodium:chloride symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral/basic amino acid(out) + Na+(out) + Cl-(out) = neutral/basic amino acid(in) + Na+(in) + Cl-(in)." [TC:2.A.22.2.3] synonym: "neutral, cationic amino acid:sodium:chloride symporter activity" RELATED [] +xref: TC:2.A.22.2.3 is_a: GO:0005283 ! amino acid:sodium symporter activity relationship: part_of GO:0006821 ! chloride transport @@ -112123,6 +112209,7 @@ id: GO:0015378 name: sodium:chloride symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in)." [TC:2.A.30.4.-] +xref: TC:2.A.30.4.- intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:17996 ! chloride intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) @@ -112158,6 +112245,7 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + Na+(out) = sulfate(in) + Na+(in)." [TC:2.A.47.1.2] synonym: "sodium:sulfate cotransporter activity" BROAD [] synonym: "sodium:sulphate symporter activity" EXACT [] +xref: TC:2.A.47.1.2 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:16189 ! sulfate intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) @@ -112169,6 +112257,7 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + bicarbonate(in) = sulfate(in) + bicarbonate(out)." [TC:2.A.53.2.2] synonym: "sulfate:hydrogencarbonate antiporter activity" EXACT [] synonym: "sulphate:bicarbonate antiporter activity" EXACT [] +xref: TC:2.A.53.2.2 intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:16189 ! sulfate intersection_of: has_primary_input CHEBI:17544 ! hydrogencarbonate @@ -112188,6 +112277,8 @@ synonym: "sodium:hydrogen exchange activity" EXACT [] synonym: "sodium:hydrogen exchanger" EXACT [] xref: MetaCyc:TRANS-RXN-129 xref: RHEA:29251 +xref: TC:2.A.35.1.1 +xref: TC:2.A.36.-.- intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) @@ -112201,6 +112292,7 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "potassium:hydrogen antiporter activity" EXACT [] xref: MetaCyc:TRANS-RXN-42 xref: RHEA:29467 +xref: TC:2.A.37.-.- intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:29103 ! potassium(1+) @@ -112214,6 +112306,7 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "potassium:hydrogen symporter activity" EXACT [] xref: MetaCyc:TRANS-RXN-3 xref: RHEA:28490 +xref: TC:2.A.38.-.- intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:29103 ! potassium(1+) @@ -112236,6 +112329,7 @@ id: GO:0015390 name: purine-specific nucleoside:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in)." [TC:2.A.41.2.1] +xref: TC:2.A.41.2.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) intersection_of: has_primary_input CHEBI:35584 ! purine @@ -112326,6 +112420,7 @@ name: urea:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urea(out) + Na+(out) = urea(in) + Na+(in)." [TC:2.A.21.6.1] synonym: "urea active transmembrane transporter activity" EXACT [] +xref: TC:2.A.21.6.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:16199 ! urea intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) @@ -112869,6 +112964,7 @@ synonym: "ATPase-coupled intramembrane lipopolysaccharide transporter activity" synonym: "lipopolysaccharide floppase activity (cytosolic to exoplasmic leaflet)" EXACT [] synonym: "lipopolysaccharide-transporting ATPase activity" EXACT [] synonym: "LPS-transporting ATPase activity" EXACT [] +xref: EC:7.5.2.5 intersection_of: GO:0140328 ! floppase activity intersection_of: has_primary_input CHEBI:16412 ! lipopolysaccharide relationship: part_of GO:0015920 ! lipopolysaccharide transport @@ -113072,6 +113168,7 @@ xref: EC:7.2.4.2 {source="skos:narrowMatch"} xref: EC:7.2.4.3 {source="skos:narrowMatch"} xref: EC:7.2.4.4 {source="skos:narrowMatch"} xref: TC:3.B +xref: TC:3.B.-.-.- intersection_of: GO:0015399 ! primary active transmembrane transporter activity intersection_of: has_part GO:0016831 ! carboxy-lyase activity property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28070" xsd:anyURI @@ -113083,6 +113180,7 @@ namespace: molecular_function def: "Primary active transport of a solute across a membrane driven by a methyl transfer reaction. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.C.-.-.-] synonym: "Methyltransfer-driven transporters" EXACT [] xref: TC:3.C +xref: TC:3.C.-.-.- intersection_of: GO:0015399 ! primary active transmembrane transporter activity intersection_of: has_part GO:0008168 ! methyltransferase activity @@ -113093,6 +113191,7 @@ namespace: molecular_function def: "Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.D.-.-.-] synonym: "oxidoreduction-driven transporter" EXACT [] xref: TC:3.D +xref: TC:3.D.-.-.- intersection_of: GO:0015399 ! primary active transmembrane transporter activity intersection_of: has_part GO:0016491 ! oxidoreductase activity @@ -113256,6 +113355,7 @@ id: GO:0015473 name: fimbrial usher porin activity namespace: molecular_function def: "A porin that acts in the assembly of fimbria together with fimbrial chaperone." [TC:1.B.11.-.-] +xref: TC:1.B.11.-.- is_a: GO:0015288 ! porin activity [Term] @@ -113263,6 +113363,7 @@ id: GO:0015474 name: autotransporter activity namespace: molecular_function def: "Transports a passenger protein from the periplasm to the external milieu; the passenger protein and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729, TC:1.B.12.-.-] +xref: TC:1.B.12.-.- is_a: GO:0015288 ! porin activity [Term] @@ -113381,6 +113482,7 @@ id: GO:0015486 name: glycoside-pentoside-hexuronide:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (glycoside, pentoside or hexuronide)(out) + monovalent cation(out) = (glycoside, pentoside or hexuronide)(in) + monovalent cation(in). The cation is Na+, Li+ or H+." [TC:2.A.2.-.-] +xref: TC:2.A.2.-.- is_a: GO:0005402 ! carbohydrate:monoatomic cation symporter activity [Term] @@ -113391,6 +113493,7 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "melibiose permease activity" RELATED [] synonym: "melibiose:cation symporter activity" BROAD [] synonym: "melibiose:monovalent cation symporter activity" EXACT [] +xref: TC:2.A.2.1.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:23906 ! monoatomic cation intersection_of: has_primary_input CHEBI:28053 ! melibiose @@ -113403,6 +113506,7 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucuronide(out) + monovalent cation(out) = glucuronide(in) + monovalent cation(in)." [TC:2.A.2.3.1] synonym: "glucuronide:monovalent cation symporter activity" EXACT [] synonym: "glucuronoside permease activity" RELATED [] +xref: TC:2.A.2.3.1 is_a: GO:0015164 ! glucuronoside transmembrane transporter activity is_a: GO:0015486 ! glycoside-pentoside-hexuronide:cation symporter activity @@ -113432,6 +113536,7 @@ name: phenylalanine:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phenylalanine(out) + H+(out) = phenylalanine(in) + H+(in)." [TC:2.A.3.1.1] synonym: "phenylalanine:hydrogen symporter activity" EXACT [] +xref: TC:2.A.3.1.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:28044 ! phenylalanine @@ -113442,6 +113547,7 @@ name: lysine:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lysine(out) + H+(out) = lysine(in) + H+(in)." [TC:2.A.3.1.2] synonym: "lysine:hydrogen symporter activity" EXACT [] +xref: TC:2.A.3.1.2 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:32564 ! lysinium(1+) @@ -113452,6 +113558,7 @@ name: aromatic amino acid:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: aromatic amino acid(out) + H+(out) = aromatic amino acid(in) + H+(in)." [TC:2.A.3.1.3] synonym: "aromatic amino acid:hydrogen symporter activity" EXACT [] +xref: TC:2.A.3.1.3 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:33856 ! aromatic amino acid @@ -113474,6 +113581,9 @@ synonym: "gamma-aminobutyric acid permease activity" EXACT [] synonym: "gamma-aminobutyric acid:hydrogen symporter activity" EXACT [] xref: MetaCyc:TRANS-RXN-57 xref: RHEA:28915 +xref: TC:2.A.18.5.1 +xref: TC:2.A.3.1.4 +xref: TC:2.A.3.4.2 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:59888 ! gamma-aminobutyric acid zwitterion @@ -113487,6 +113597,7 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "putrescine-ornithine antiporter activity" EXACT [] synonym: "putrescine/ornithine antiporter activity" EXACT [] synonym: "putrescine:hydrogen symporter activity" EXACT [] +xref: TC:2.A.3.2.1 intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:326268 ! 1,4-butanediammonium intersection_of: has_primary_input CHEBI:46911 ! L-ornithinium(1+) @@ -113496,6 +113607,7 @@ id: GO:0015498 name: pantothenate:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: pantothenate(out) + Na+(out) = pantothenate(in) + Na+(in)." [TC:2.A.21.1.1] +xref: TC:2.A.21.1.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:16454 ! pantothenate intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) @@ -113538,6 +113650,7 @@ synonym: "sodium/excitatory glutamate cotransporter activity" BROAD [] synonym: "sodium/excitatory glutamate symporter activity" EXACT [] xref: MetaCyc:TRANS-RXN-122 xref: RHEA:29031 +xref: TC:2.A.27.1.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:14321 ! glutamate(1-) intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) @@ -113548,6 +113661,8 @@ id: GO:0015503 name: glutathione-regulated potassium exporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in), where glutathione maintains the closed state." [PMID:11053405, TC:2.A.37.1.1, TC:2.A.37.1.2] +xref: TC:2.A.37.1.1 +xref: TC:2.A.37.1.2 is_a: GO:0015079 ! potassium ion transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity @@ -113558,6 +113673,7 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cytosine(out) + H+(out) = cytosine(in) + H+(in)." [TC:2.A.39.1.1] synonym: "cytosine permease activity" RELATED [] synonym: "cytosine:hydrogen ion symporter activity" EXACT [] +xref: TC:2.A.39.1.1 intersection_of: GO:0015295 ! solute:proton symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:16040 ! cytosine @@ -113583,6 +113699,8 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "nucleoside permease activity" RELATED [] synonym: "nucleoside:hydrogen ion symporter activity" EXACT [] synonym: "nucleoside:hydrogen symporter activity" EXACT [] +xref: TC:2.A.1.10.1 +xref: TC:2.A.41.1.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:33838 ! nucleoside @@ -113623,6 +113741,7 @@ name: citrate:succinate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + succinate(in) = citrate(in) + succinate(out)." [TC:2.A.47.3.2] xref: RHEA:28835 +xref: TC:2.A.47.3.2 intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:16947 ! citrate(3-) intersection_of: has_primary_input CHEBI:30031 ! succinate(2-) @@ -113633,6 +113752,7 @@ id: GO:0015516 name: tartrate:succinate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: tartrate(out) + succinate(in) = tartrate(in) + succinate(out)." [TC:2.A.47.3.3] +xref: TC:2.A.47.3.3 intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:30031 ! succinate(2-) intersection_of: has_primary_input CHEBI:50562 ! tartrate salt @@ -113644,6 +113764,8 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + H+(out) = galactose(in) + H+(in)." [TC:2.A.1.1.1, TC:2.A.1.1.9] synonym: "galactose:hydrogen symporter activity" EXACT [] synonym: "lactose, galactose:hydrogen symporter activity" BROAD [] +xref: TC:2.A.1.1.1 +xref: TC:2.A.1.1.9 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:28260 ! galactose @@ -113657,6 +113779,7 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "arabinose efflux permease activity" BROAD [] synonym: "arabinose efflux transmembrane transporter activity" BROAD [] synonym: "arabinose:hydrogen symporter activity" EXACT [] +xref: TC:2.A.1.1.2 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:22599 ! arabinose @@ -113667,6 +113790,7 @@ name: D-xylose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-xylose(out) + H+(out) = D-xylose(in) + H+(in)." [TC:2.A.1.1.3] synonym: "D-xylose:hydrogen symporter activity" EXACT [] +xref: TC:2.A.1.1.3 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:15936 ! aldehydo-D-xylose @@ -113679,6 +113803,7 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "tetracyclin:hydrogen antiporter activity" EXACT [] synonym: "tetracyclin:proton antiporter activity" EXACT [] synonym: "tetracycline:hydrogen antiporter activity" EXACT [] +xref: TC:2.A.1.2.4 intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:77932 ! tetracycline zwitterion @@ -113734,6 +113859,7 @@ name: hexose-phosphate:phosphate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose phosphate(out) + phosphate(in) = hexose phosphate(in) + phosphate(out)." [TC:2.A.1.4.1] synonym: "hexose-phosphate:inorganic phosphate antiporter activity" EXACT [] +xref: TC:2.A.1.4.1 intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:43474 ! hydrogenphosphate intersection_of: has_primary_input CHEBI:47878 ! hexose phosphate @@ -113744,6 +113870,7 @@ name: glycerol-phosphate:phosphate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerol phosphate(out) + phosphate(in) = glycerol phosphate(in) + phosphate(out)." [TC:2.A.1.4.3] synonym: "glycerol-phosphate:inorganic phosphate antiporter activity" EXACT [] +xref: TC:2.A.1.4.3 intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:26707 ! glycerol phosphate intersection_of: has_primary_input CHEBI:43474 ! hydrogenphosphate @@ -113755,6 +113882,8 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactose(out) + H+(out) = lactose(in) + H+(in)." [TC:2.A.1.1.9, TC:2.A.1.5.1] synonym: "lactose, galactose:hydrogen symporter activity" BROAD [] synonym: "lactose:hydrogen symporter activity" EXACT [] +xref: TC:2.A.1.1.9 +xref: TC:2.A.1.5.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:17716 ! lactose @@ -113765,6 +113894,7 @@ name: raffinose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: raffinose(out) + H+(out) = raffinose(in) + H+(in)." [TC:2.A.1.5.2] synonym: "raffinose:hydrogen symporter activity" EXACT [] +xref: TC:2.A.1.5.2 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:16634 ! raffinose @@ -113785,6 +113915,7 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + H+(out) = citrate(in) + H+(in)." [TC:2.A.1.6.1] synonym: "citrate:hydrogen symporter activity" EXACT [] xref: RHEA:32123 +xref: TC:2.A.1.6.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:16947 ! citrate(3-) @@ -113797,6 +113928,7 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "2-oxoglutarate:hydrogen symporter activity" EXACT [] synonym: "2-oxoglutarate:proton symporter activity" EXACT [] synonym: "alpha-ketoglutarate:hydrogen symporter activity" EXACT [] +xref: TC:2.A.1.6.2 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:16810 ! 2-oxoglutarate(2-) @@ -113807,6 +113939,7 @@ name: shikimate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: shikimate(out) + H+(out) = shikimate(in) + H+(in)." [TC:2.A.1.6.6] synonym: "shikimate:hydrogen symporter activity" EXACT [] +xref: TC:2.A.1.6.6 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:36208 ! shikimate @@ -113835,6 +113968,7 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "fucose:hydrogen symporter activity" EXACT [] xref: MetaCyc:TRANS-RXN-20 xref: RHEA:29023 +xref: TC:2.A.1.7.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:33984 ! fucose @@ -113847,6 +113981,7 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: xanthosine(out) + H+(out) = xanthosine(in) + H+(in)." [TC:2.A.1.10.2] synonym: "xanthosine permease activity" RELATED [] synonym: "xanthosine:hydrogen ion symporter activity" EXACT [] +xref: TC:2.A.1.10.2 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:18107 ! xanthosine @@ -113860,6 +113995,7 @@ synonym: "sialic acid permease activity" RELATED [] synonym: "sialic acid:hydrogen symporter activity" EXACT [] xref: MetaCyc:TRANS-RXN-25 xref: RHEA:28987 +xref: TC:2.A.1.12.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:26667 ! sialic acid @@ -113873,6 +114009,7 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "hexuronate (glucuronate/galacturonate) porter activity" NARROW [] synonym: "hexuronate porter activity" RELATED [] synonym: "hexuronate:cation symporter activity" BROAD [] +xref: TC:2.A.1.14.2 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:23906 ! monoatomic cation intersection_of: has_primary_input CHEBI:24591 ! hexuronate @@ -113885,6 +114022,7 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-hydroxyphenyl propionate(out) + H+(out) = 3-hydroxyphenyl propionate(in) + H+(in)." [TC:2.A.1.15.2] synonym: "3-hydroxyphenyl propionate porter activity" RELATED [] synonym: "3-hydroxyphenyl propionate:hydrogen ion symporter activity" EXACT [] +xref: TC:2.A.1.15.2 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:65228 ! 3-hydroxyphenyl propanoate @@ -113895,6 +114033,7 @@ name: secondary active cyanate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cyanate from one side of a membrane to the other." [TC:2.A.1.17.1] synonym: "cyanate porter activity" RELATED [] +xref: TC:2.A.1.17.1 intersection_of: GO:0015291 ! secondary active transmembrane transporter activity intersection_of: has_primary_input CHEBI:29195 ! cyanate relationship: part_of GO:0015704 ! cyanate transport @@ -113915,6 +114054,7 @@ name: phenyl propionate uniporter activity namespace: molecular_function def: "Enables the transfer of phenyl propionate from one side of a membrane to the other." [GOC:mtg_transport, TC:2.A.1.27.1] synonym: "phenyl propionate permease activity" RELATED [] +xref: TC:2.A.1.27.1 is_a: GO:0015292 ! uniporter activity is_a: GO:0015552 ! propionate transmembrane transporter activity @@ -114271,6 +114411,7 @@ def: "Catalysis of the reaction: ATP + H2O + putrescine(out) -> ADP + phosphate synonym: "ATPase-coupled putrescine transmembrane transporter activity" RELATED [] synonym: "putrescine porter activity" BROAD [] synonym: "putrescine-importing ATPase activity" NARROW [] +xref: EC:7.6.2.11 xref: EC:7.6.2.16 xref: MetaCyc:ABC-25-RXN xref: RHEA:29995 @@ -114774,6 +114915,7 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "2-keto-3-deoxygluconate:hydrogen symporter activity" EXACT [] xref: MetaCyc:TRANS-RXN-113 xref: RHEA:29943 +xref: TC:2.A.10.1.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:57990 ! 2-dehydro-3-deoxy-D-gluconate @@ -114790,6 +114932,7 @@ synonym: "lactate permease" BROAD [] synonym: "lactate:hydrogen porter activity" EXACT [] synonym: "lactate:hydrogen symporter activity" EXACT [] synonym: "lactate:proton porter activity" EXACT [] +xref: TC:2.A.14.1.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:24996 ! lactate @@ -114824,6 +114967,7 @@ name: glycine betaine:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + H+(out) = glycine betaine(in) + H+(in)." [TC:2.A.15.1.1] synonym: "glycine betaine:hydrogen symporter activity" EXACT [] +xref: TC:2.A.15.1.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:15378 ! hydron intersection_of: has_primary_input CHEBI:17750 ! glycine betaine @@ -114862,6 +115006,7 @@ id: GO:0015657 name: branched-chain amino acid:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: branched-chain amino acid(out) + cation(out) = branched-chain amino acid(in) + cation(in)." [TC:2.A.26.1.1] +xref: TC:2.A.26.1.1 intersection_of: GO:0015293 ! symporter activity intersection_of: has_primary_input CHEBI:22918 ! branched-chain amino acid intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) @@ -127846,6 +127991,7 @@ name: delta1-pyrroline-5-carboxylate synthetase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + ATP + NADPH = ADP + L-glutamate gamma-semialdehyde + NADP+ + phosphate." [MetaCyc:PROLINE-MULTI] synonym: "D1-pyrroline-5-carboxylate synthetase activity" EXACT [] +xref: MetaCyc:PROLINE-MULTI xref: RHEA:33207 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor @@ -134621,6 +134767,7 @@ name: methyl tertiary butyl ether 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: methyl tert-butyl ether + 1/2 O2 = tert-butyl alcohol + formaldehyde." [UM-BBD_reactionID:r1023] synonym: "MTBE 3-monooxygenase activity" EXACT [] +xref: UM-BBD_reactionID:r1023 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen @@ -134649,6 +134796,7 @@ name: tert-butanol 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: tert-butanol + 1/2 O2 = 2-methyl-2-hydroxy-1-propanol." [UM-BBD_reactionID:r0615] synonym: "tert-butyl alcohol 2-monooxygenase activity" EXACT [] +xref: UM-BBD_reactionID:r0615 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen @@ -136488,6 +136636,7 @@ id: GO:0018755 name: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + OH- = 2,4-dihydroxy-6-amino-1,3,5-triazine + Cl-." [UM-BBD_reactionID:r1414] +xref: UM-BBD_reactionID:r1414 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] @@ -137262,6 +137411,7 @@ synonym: "(hydroxyamino)benzene hydroxymutase activity" RELATED [EC:5.4.4.1] synonym: "HAB mutase activity" RELATED [EC:5.4.4.1] synonym: "hydroxylaminobenzene hydroxymutase activity" RELATED [EC:5.4.4.1] synonym: "hydroxylaminobenzene mutase activity" RELATED [EC:5.4.4.1] +xref: EC:5.4.4.1 xref: MetaCyc:5.4.4.1-RXN xref: RHEA:19245 xref: UM-BBD_reactionID:r0304 @@ -138099,6 +138249,7 @@ synonym: "2,4-D metabolic process" EXACT [] synonym: "2,4-D metabolism" EXACT [] synonym: "2,4-dichlorophenoxyacetic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:2\,4-d +xref: UM-BBD_pathwayID:2\,4d intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:19351 ! (2,4-dichlorophenoxy)acetate @@ -138849,6 +139000,7 @@ def: "The chemical reactions and pathways involving toluene, a volatile monoarom synonym: "methylbenzene metabolic process" EXACT [] synonym: "methylbenzene metabolism" EXACT [] synonym: "toluene metabolism" EXACT [] +xref: UM-BBD_pathwayID:tol intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:17578 ! toluene @@ -138999,6 +139151,7 @@ name: Z-phenylacetaldoxime metabolic process namespace: biological_process def: "The chemical reactions and pathways involving Z-phenylacetaldoxime, a member of the glucosinolate group of compounds, a class of natural products that are gaining increasing interest as cancer-preventing agents and crop protectants." [UM-BBD_pathwayID:car] synonym: "Z-phenylacetaldoxime metabolism" EXACT [] +xref: UM-BBD_pathwayID:car xref: UM-BBD_pathwayID:pao intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:50723 ! (Z)-phenylacetaldehyde oxime @@ -140242,6 +140395,8 @@ id: GO:0019118 name: phenanthrene-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: a phenanthrene dioxide + H2O = a dihydrodiolphenanthrene." [GOC:mah, UM-BBD_reactionID:r0535, UM-BBD_reactionID:r0536] +xref: UM-BBD_reactionID:r0535 +xref: UM-BBD_reactionID:r0536 is_a: GO:0004301 ! epoxide hydrolase activity property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27074" xsd:anyURI @@ -140250,6 +140405,8 @@ id: GO:0019119 name: phenanthrene-9,10-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene." [GOC:mah, UM-BBD_reactionID:r0496, UM-BBD_reactionID:r0560] +xref: UM-BBD_reactionID:r0496 +xref: UM-BBD_reactionID:r0560 is_a: GO:0019118 ! phenanthrene-epoxide hydrolase activity [Term] @@ -142013,6 +142170,7 @@ synonym: "isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [] synonym: "isopentenyl diphosphate biosynthetic process via mevalonate" EXACT [GOC:pr] synonym: "isopentenyl diphosphate formation, mevalonate pathway" EXACT [] synonym: "isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [] +xref: MetaCyc:PWY-922 is_a: GO:0006084 ! acetyl-CoA metabolic process is_a: GO:0009240 ! isopentenyl diphosphate biosynthetic process intersection_of: GO:0009058 ! biosynthetic process @@ -142523,6 +142681,9 @@ id: GO:0019329 name: ammonia oxidation namespace: biological_process def: "The chemical reactions and pathways by which ammonia or ammonium is converted to molecular nitrogen or another nitrogen compound, with accompanying loss of electrons." [GOC:mah, MetaCyc:AMMOXID-PWY, MetaCyc:P303-PWY, MetaCyc:PWY-2242] +xref: MetaCyc:AMMOXID-PWY +xref: MetaCyc:P303-PWY +xref: MetaCyc:PWY-2242 is_a: GO:0044281 ! small molecule metabolic process [Term] @@ -142639,6 +142800,7 @@ synonym: "parathion breakdown" EXACT [] synonym: "parathion catabolism" EXACT [] synonym: "parathion degradation" EXACT [] xref: MetaCyc:PARATHION-DEGRADATION-PWY +xref: UM-BBD_pathwayID:pthn intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:27928 ! parathion @@ -143107,6 +143269,7 @@ synonym: "atrazine breakdown" EXACT [] synonym: "atrazine catabolism" EXACT [] synonym: "atrazine degradation" EXACT [] xref: MetaCyc:PWY-5724 +xref: UM-BBD_pathwayID:atr intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:15930 ! atrazine property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28388" xsd:anyURI @@ -143131,6 +143294,7 @@ synonym: "(+)-camphor breakdown" EXACT [] synonym: "(+)-camphor catabolism" EXACT [] synonym: "(+)-camphor degradation" EXACT [] xref: MetaCyc:P601-PWY +xref: UM-BBD_pathwayID:cam intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:15396 ! (R)-camphor @@ -143523,6 +143687,8 @@ name: sulfur oxidation namespace: biological_process def: "The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur." [GOC:jl, MetaCyc:FESULFOX-PWY, MetaCyc:SULFUROX-PWY] synonym: "sulphur oxidation" EXACT [] +xref: MetaCyc:FESULFOX-PWY +xref: MetaCyc:SULFUROX-PWY is_a: GO:0006790 ! sulfur compound metabolic process [Term] @@ -143719,6 +143885,7 @@ name: sophorosyloxydocosanoate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate, an aromatic hydrocarbon." [MetaCyc:DIGLUCODIACETYL-DOCOSANOATE] synonym: "sophorosyloxydocosanoate metabolism" EXACT [] +xref: MetaCyc:DIGLUCODIACETYL-DOCOSANOATE intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:51078 ! 13-sophorosyloxydocosanoate 6',6''-diacetate @@ -144343,6 +144510,7 @@ namespace: biological_process def: "The removal of the sulfonate group from 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [UM-BBD_pathwayID:abs] synonym: "2-aminobenzenesulphonate desulphonation" EXACT [] xref: MetaCyc:2ASDEG-PWY +xref: UM-BBD_pathwayID:abs is_a: GO:0018868 ! 2-aminobenzenesulfonate metabolic process [Term] @@ -144411,6 +144579,8 @@ name: hexachlorocyclohexane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hexachlorocyclohexane, a cyclohexane derivative with 6 chlorine atoms attached to the hexane ring. Hexachlorocyclohexane consists of a mixture of 8 different isomers and was used a commercial insecticide. It is persistent in the environment, causing serious soil pollution." [UM-BBD_pathwayID:ghch, UM-BBD_pathwayID:hch] synonym: "hexachlorocyclohexane metabolism" EXACT [] +xref: UM-BBD_pathwayID:ghch +xref: UM-BBD_pathwayID:hch intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:24536 ! hexachlorocyclohexane @@ -144647,6 +144817,7 @@ synonym: "L-threonine catabolic process to pyruvate" RELATED [GOC:bf, GOC:mah] synonym: "L-threonine catabolism to D-lactate" EXACT [GOC:bf, GOC:mah] synonym: "L-threonine degradation to D-lactate" EXACT [GOC:bf] synonym: "threonine catabolic process to D-lactate" BROAD [GOC:bf] +xref: MetaCyc:PWY-901 xref: MetaCyc:THRDLCTCAT-PWY is_a: GO:0006089 ! lactate metabolic process is_a: GO:0006567 ! threonine catabolic process @@ -146144,6 +146315,7 @@ namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of citrate to diacetyl, yielding energy in the form of ATP." [MetaCyc:P126-PWY] synonym: "citrate fermentation to diacetyl" EXACT [] synonym: "diacetyl fermentation" EXACT [] +xref: MetaCyc:P126-PWY is_a: GO:0019662 ! non-glycolytic fermentation intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:16947 ! citrate(3-) @@ -146309,6 +146481,7 @@ id: GO:0019662 name: non-glycolytic fermentation namespace: biological_process def: "Fermentation that does not include the anaerobic conversion of glucose to pyruvate via the glycolytic pathway." [GOC:jl, MetaCyc:Fermentation] +xref: MetaCyc:Fermentation is_a: GO:0006113 ! fermentation [Term] @@ -146318,6 +146491,7 @@ namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into ethanol, lactate, formate, succinate, and acetate, yielding energy in the form of ATP." [ISBN:0716720094, MetaCyc:FERMENTATION-PWY] synonym: "glucose catabolic process to mixed acids" BROAD [] synonym: "glucose fermentation to mixed acids" EXACT [] +xref: MetaCyc:FERMENTATION-PWY xref: Wikipedia:Mixed_acid_fermentation is_a: GO:0019660 ! glycolytic fermentation intersection_of: GO:0019660 ! glycolytic fermentation @@ -146335,6 +146509,7 @@ name: anaerobic amino acid catabolic process namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids, yielding energy in the form of ATP." [GOC:curators, GOC:jl, MetaCyc:Fermentation] synonym: "amino acid fermentation" EXACT [] +xref: MetaCyc:Fermentation is_a: GO:0006113 ! fermentation is_a: GO:0009063 ! amino acid catabolic process @@ -146401,6 +146576,7 @@ id: GO:0019672 name: ethanol-acetate fermentation to butyrate and caproate namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of ethanol and acetate to butyrate and caproate, yielding energy in the form of ATP." [MetaCyc:P127-PWY] +xref: MetaCyc:P127-PWY is_a: GO:0019662 ! non-glycolytic fermentation [Term] @@ -146533,6 +146709,7 @@ synonym: "acetyl-CoA catabolism to 2-ketoglutarate" EXACT [] synonym: "acetyl-CoA catabolism to 2-oxoglutarate" EXACT [] synonym: "acetyl-CoA catabolism to alpha-ketoglutarate" EXACT [] synonym: "acetyl-CoA catabolism to alpha-oxoglutarate" EXACT [] +xref: MetaCyc:P22-PWY is_a: GO:0006103 ! 2-oxoglutarate metabolic process is_a: GO:0046356 ! acetyl-CoA catabolic process @@ -183692,7 +183869,6 @@ comment: Note that this term is in the subset of terms that should not be used f subset: gocheck_do_not_annotate synonym: "interferon type I production" EXACT [] synonym: "type I IFN production" EXACT [GOC:mah] -synonym: "type I IFN production" EXACT [] synonym: "type I interferon biosynthetic process" NARROW [] synonym: "type I interferon secretion" NARROW [] is_a: GO:0001816 ! cytokine production @@ -191663,6 +191839,7 @@ name: quercetin O-glucoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving O-glucosylated derivatives of quercetin." [GOC:mah, MetaCyc:PWY-5321] synonym: "quercetin O-glucoside metabolism" EXACT [] +xref: MetaCyc:PWY-5321 intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:64621 ! quercetin O-glucoside @@ -191872,6 +192049,7 @@ name: homomethionine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving homomethionine, a non-protein amino acid synthesized from methionine via chain elongation." [GOC:mah, MetaCyc:PWY-1186] synonym: "homomethionine metabolism" EXACT [] +xref: MetaCyc:PWY-1186 intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:62936 ! homomethioninate @@ -191970,6 +192148,7 @@ name: kaempferol O-glucoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving O-glucosylated derivatives of kaempferol." [GOC:mah, MetaCyc:PWY-5320] synonym: "kaempferol O-glucoside metabolism" EXACT [] +xref: MetaCyc:PWY-5320 is_a: GO:0016137 ! glycoside metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:169942 ! kaempferol 3-O-beta-D-glucoside(1-) @@ -191995,6 +192174,7 @@ name: ent-kaurene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ent-kaur-16-ene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins." [GOC:mah, MetaCyc:PWY-5032, PMID:17064690] synonym: "ent-kaurene metabolism" EXACT [] +xref: MetaCyc:PWY-5032 intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:15415 ! ent-kaurene @@ -192295,6 +192475,7 @@ synonym: "lysine biosynthetic process via diaminopimelic acid and N-succinyl-2-a synonym: "lysine formation via diaminopimelate and N-succinyl-2-amino-6-ketopimelate" EXACT [] synonym: "lysine synthesis via diaminopimelate and N-succinyl-2-amino-6-ketopimelate" EXACT [] xref: MetaCyc:DAPLYSINESYN-PWY +xref: MetaCyc:DAPLYSINESYN-PWY- intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_intermediate CHEBI:15685 ! L-2-succinylamino-6-oxoheptanedioate(3-) intersection_of: has_intermediate CHEBI:57791 ! meso-2,6-diaminopimelic acid dizwitterion @@ -192592,6 +192773,7 @@ namespace: biological_process def: "The chemical reactions and pathways involving geranyl diphosphate, the universal precursor of the monoterpenes." [GOC:mah, MetaCyc:PWY-5122] synonym: "geranyl diphosphate metabolism" EXACT [] synonym: "geranyldiphosphate metabolic process" EXACT [] +xref: MetaCyc:PWY-5122 intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:58057 ! geranyl diphosphate(3-) @@ -192616,6 +192798,7 @@ namespace: biological_process def: "The chemical reactions and pathways involving geranylgeranyl diphosphate, a polyprenol compound involved in the biosynthesis of a variety of terpenoids including chlorophylls, carotenoids, tocopherols, plastoquinones, and the plant hormones gibberellins." [GOC:mah, MetaCyc:PWY-5120] synonym: "geranylgeranyl diphosphate metabolism" EXACT [] synonym: "geranylgeranyldiphosphate metabolic process" EXACT [] +xref: MetaCyc:PWY-5120 intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:57533 ! geranylgeranyl diphosphate(3-) @@ -192628,6 +192811,7 @@ synonym: "geranylgeranyl diphosphate anabolism" EXACT [] synonym: "geranylgeranyl diphosphate biosynthesis" EXACT [] synonym: "geranylgeranyl diphosphate formation" EXACT [] synonym: "geranylgeranyl diphosphate synthesis" EXACT [] +xref: MetaCyc:PWY-5120 xref: MetaCyc:PWY-5121 {source="skos:narrowMatch"} xref: MetaCyc:PWY-5910 {source="skos:narrowMatch"} intersection_of: GO:0009058 ! biosynthetic process @@ -192643,6 +192827,7 @@ synonym: "putrescine anabolism from ornithine" EXACT [] synonym: "putrescine biosynthesis from ornithine" EXACT [] synonym: "putrescine formation from ornithine" EXACT [] synonym: "putrescine synthesis from ornithine" EXACT [] +xref: MetaCyc:PWY-46 intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_input CHEBI:46912 ! ornithinium(1+) intersection_of: has_primary_output CHEBI:326268 ! 1,4-butanediammonium @@ -192656,6 +192841,7 @@ synonym: "putrescine anabolism from arginine" EXACT [] synonym: "putrescine biosynthesis from arginine" EXACT [] synonym: "putrescine formation from arginine" EXACT [] synonym: "putrescine synthesis from arginine" EXACT [] +xref: MetaCyc:PWY-46 intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_input CHEBI:32696 ! argininium(1+) intersection_of: has_primary_output CHEBI:326268 ! 1,4-butanediammonium @@ -192669,6 +192855,7 @@ synonym: "putrescine anabolism from arginine, using agmatinase" EXACT [] synonym: "putrescine biosynthesis from arginine, using agmatinase" EXACT [] synonym: "putrescine formation from arginine, using agmatinase" EXACT [] synonym: "putrescine synthesis from arginine, using agmatinase" EXACT [] +xref: MetaCyc:PWY-40 intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_intermediate CHEBI:58145 ! agmatinium(2+) intersection_of: has_primary_input CHEBI:32696 ! argininium(1+) @@ -192683,6 +192870,7 @@ synonym: "putrescine anabolism from arginine via N-carbamoylputrescine" EXACT [] synonym: "putrescine biosynthesis from arginine via N-carbamoylputrescine" EXACT [] synonym: "putrescine formation from arginine via N-carbamoylputrescine" EXACT [] synonym: "putrescine synthesis from arginine via N-carbamoylputrescine" EXACT [] +xref: MetaCyc:PWY-43 intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_intermediate CHEBI:58318 ! N-carbamoylputrescinium(1+) intersection_of: has_primary_input CHEBI:32696 ! argininium(1+) @@ -193849,6 +194037,7 @@ synonym: "galactose breakdown via UDP-galactose" EXACT [] synonym: "galactose catabolism via UDP-galactose" EXACT [] synonym: "galactose degradation via UDP-galactose" EXACT [] synonym: "Leloir Pathway" RELATED [PMID:14741191] +xref: MetaCyc:PWY-3821 xref: MetaCyc:PWY-6317 intersection_of: GO:0009056 ! catabolic process intersection_of: has_intermediate CHEBI:58439 ! UDP-D-galactose(2-) @@ -194336,6 +194525,7 @@ id: GO:0033543 name: fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway namespace: biological_process def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to trans-2-enoyl-CoA by 2,4-dienoyl-CoA reductase and delta3-delta2-enoyl-CoA isomerase; trans-2-enoyl-CoA returns to the core beta-oxidation pathway for further degradation. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5138] +xref: MetaCyc:PWY-5138 is_a: GO:0033542 ! fatty acid beta-oxidation, unsaturated, even number [Term] @@ -194343,6 +194533,7 @@ id: GO:0033544 name: fatty acid beta-oxidation, unsaturated, even number, epimerase pathway namespace: biological_process def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to cis-2-enoyl-CoA through one more cycle of the core beta-oxidation pathway. Cis-2-enoyl-CoA cannot be completely degraded via the core beta-oxidation pathway because hydratation of cis-2-enoyl-CoA yields D-3-hydroxyacyl-CoA, which is not a substrate for 3-hydroxylacyl-CoA dehydrogenase. Cis-2-enoyl-CoA must enter the so-called epimerase pathway, which involves converting D-3-hydroxyacyl-CoA to L-3-hydroxyacyl-CoA by 3-hydroxylacyl-CoA epimerase or by two stereo-specific enoyl-CoA hydratases. L-3-hydroxyacyl-CoA then returns to the core beta-oxidation pathway. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5138] +xref: MetaCyc:PWY-5138 is_a: GO:0033542 ! fatty acid beta-oxidation, unsaturated, even number [Term] @@ -199472,6 +199663,7 @@ namespace: molecular_function def: "Catalysis of the reaction: N-benzylformamide + H2O = formate + benzylamine." [EC:3.5.1.91] synonym: "N-benzylformamide amidohydrolase activity" RELATED [EC:3.5.1.91] synonym: "NfdA" RELATED [EC:3.5.1.91] +xref: EC:3.5.1.91 xref: MetaCyc:3.5.1.91-RXN xref: RHEA:12096 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides @@ -200869,6 +201061,7 @@ def: "The chemical reactions and pathways involving butanediol; the biologically synonym: "butanediol metabolism" EXACT [] synonym: "butylene glycol metabolic process" EXACT [] synonym: "butylene glycol metabolism" EXACT [] +xref: MetaCyc:BUTANEDIOL intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:62064 ! butane-2,3-diol property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28388" xsd:anyURI @@ -200884,6 +201077,8 @@ synonym: "butanediol degradation" EXACT [] synonym: "butanediol utilization" RELATED [] synonym: "butylene glycol catabolic process" EXACT [] synonym: "butylene glycol catabolism" EXACT [] +xref: MetaCyc:125-PWY +xref: MetaCyc:BUTANEDIOL intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:62064 ! butane-2,3-diol @@ -200898,6 +201093,7 @@ synonym: "butanediol formation" EXACT [] synonym: "butanediol synthesis" EXACT [] synonym: "butylene glycol biosynthesis" EXACT [] synonym: "butylene glycol biosynthetic process" EXACT [] +xref: MetaCyc:BUTANEDIOL xref: MetaCyc:P125-PWY intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:62064 ! butane-2,3-diol @@ -214339,6 +214535,7 @@ synonym: "L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside lig synonym: "MshC ligase" RELATED [EC:6.3.1.13] xref: EC:6.3.1.13 xref: MetaCyc:RXN1G-121 +xref: MetaCyc:RXN1G-4 xref: RHEA:26176 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28183" xsd:anyURI @@ -223831,6 +224028,7 @@ namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate into 4-hydroxybutyrate." [GOC:bf, MetaCyc:PWY-4321] comment: In the catabolism of glutamate in mammals, succinate semialdehyde is converted to succinate (see GO:0006540). Plants can utilize an alternative route, converting succinic semialdehyde to 4-hydroxybutyrate using gamma-hydroxybutyrate dehydrogenase. synonym: "glutamate degradation to 4-hydroxybutyrate" EXACT [MetaCyc:PWY-4321] +xref: MetaCyc:PWY-4321 is_a: GO:0006538 ! glutamate catabolic process intersection_of: GO:0006538 ! glutamate catabolic process intersection_of: has_primary_output CHEBI:16724 ! 4-hydroxybutyrate @@ -235088,6 +235286,7 @@ name: cyanuric acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyanuric acid, a suspected gastrointestinal or liver toxicant, and a potential degradation product of triazine herbicides, such as atrazine and simazine. It is widely used for the stabilization of available chlorine in swimming pool water and is also the starting compound for the synthesis of many organic derivatives." [UM-BBD_pathwayID:cya] synonym: "cyanuric acid metabolism" EXACT [] +xref: UM-BBD_pathwayID:cya intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:38028 ! cyanuric acid @@ -235111,6 +235310,7 @@ def: "The chemical reactions and pathways involving N-cyclopropylmelamine, a tri synonym: "cyromazine metabolic process" EXACT [] synonym: "cyromazine metabolism" EXACT [] synonym: "N-cyclopropylmelamine metabolism" EXACT [] +xref: UM-BBD_pathwayID:cpm intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:30260 ! cyromazine @@ -235255,6 +235455,7 @@ def: "The chemical reactions and pathways involving cresol, a mixture of the aro synonym: "cresol metabolism" EXACT [] synonym: "hydroxytoluene metabolic process" EXACT [] synonym: "hydroxytoluene metabolism" EXACT [] +xref: UM-BBD_pathwayID:mcr intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:25399 ! cresol @@ -242482,6 +242683,7 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + antimonite(in) = ADP + phosphate + antimonite(out)." [EC:7.3.2.7] synonym: "antimonite-transporting ATPase activity" EXACT [] synonym: "ATP-dependent antimonite transporter activity" EXACT [] +xref: EC:7.3.2.7 intersection_of: GO:0042626 ! ATPase-coupled transmembrane transporter activity intersection_of: has_primary_input CHEBI:49870 ! antimonous acid relationship: part_of GO:0015699 ! antimonite transmembrane transport @@ -243326,6 +243528,7 @@ def: "The chemical reactions and pathways by which the various amino acids becom synonym: "aminoacyl-tRNA biosynthesis" EXACT [GOC:mah] synonym: "aminoacyl-tRNA biosynthetic process" EXACT [GOC:mah] synonym: "tRNA charging" EXACT [] +xref: MetaCyc:Aminoacyl-tRNAs is_a: GO:0006399 ! tRNA metabolic process is_a: GO:0043038 ! amino acid activation @@ -251950,6 +252153,7 @@ synonym: "cadaverine transmembrane transporter activity" NARROW [] synonym: "cadaverine:lysine antiporter activity" EXACT [] synonym: "lysine-cadaverine antiporter activity" EXACT [] synonym: "lysine/cadaverine antiporter activity" EXACT [] +xref: TC:2.A.3.2.2 intersection_of: GO:0015297 ! antiporter activity intersection_of: has_primary_input CHEBI:32564 ! lysinium(1+) intersection_of: has_primary_input CHEBI:58384 ! cadaverine(2+) @@ -278683,6 +278887,7 @@ name: rhizobactin 1021 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti." [MetaCyc:PWY-761, PMID:11274118] synonym: "rhizobactin 1021 metabolism" EXACT [] +xref: MetaCyc:PWY-761 is_a: GO:0009237 ! siderophore metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:74252 ! rhizobactin 1021 @@ -278730,6 +278935,7 @@ name: S-adenosylmethioninamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt." [GOC:mah, MetaCyc:S-ADENOSYLMETHIONINAMINE] synonym: "S-adenosylmethioninamine metabolism" EXACT [] +xref: MetaCyc:S-ADENOSYLMETHIONINAMINE intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:57443 ! S-adenosylmethioninaminium @@ -284471,6 +284677,7 @@ synonym: "3alpha-hydroxysteroid dehydrogenase (A-specific)" BROAD [EC:1.1.1.213] synonym: "3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (A-specific)" BROAD [EC:1.1.1.213] xref: EC:1.1.1.213 xref: MetaCyc:1.1.1.209-RXN {source="skos:broadMatch"} +xref: MetaCyc:1.1.1.213-RXN xref: Wikipedia:3alpha-hydroxysteroid_dehydrogenase_(A-specific) is_a: GO:0047023 ! androsterone dehydrogenase activity property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28176" xsd:anyURI @@ -284702,6 +284909,7 @@ synonym: "hydroxyprostaglandin dehydrogenase activity" RELATED [EC:1.1.1.50] synonym: "sterognost 3alpha" RELATED [EC:1.1.1.50] xref: EC:1.1.1.50 xref: MetaCyc:1.1.1.209-RXN {source="skos:broadMatch"} +xref: MetaCyc:1.1.1.50-RXN xref: Wikipedia:3alpha-hydroxysteroid_dehydrogenase_(B-specific) is_a: GO:0047023 ! androsterone dehydrogenase activity property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28176" xsd:anyURI @@ -287379,6 +287587,7 @@ synonym: "UDP-glucose:13-hydroxydocosanoic acid glucosyltransferase activity" RE synonym: "UDPglucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.158] synonym: "uridine diphosphoglucose-hydroxydocosanoate glucosyltransferase activity" RELATED [EC:2.4.1.158] xref: EC:2.4.1.158 +xref: MetaCyc:2.4.1.158-RXN xref: MetaCyc:HYDROXYDOCOSANOATE-TRANS-RXN xref: RHEA:22316 is_a: GO:0035251 ! UDP-glucosyltransferase activity @@ -287449,6 +287658,7 @@ synonym: "raffinose-raffinose alpha-galactosyltransferase activity" EXACT [] synonym: "raffinose:raffinose alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.166] synonym: "raffinose:raffinose alpha-galactosyltransferase activity" RELATED [EC:2.4.1.166] xref: EC:2.4.1.166 +xref: MetaCyc:2.4.1.166-RXN xref: MetaCyc:RXN-11490 xref: RHEA:14125 is_a: GO:0008378 ! galactosyltransferase activity @@ -287512,6 +287722,7 @@ synonym: "UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta- synonym: "UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.175] synonym: "uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II activity" RELATED [EC:2.4.1.175] xref: EC:2.4.1.175 +xref: MetaCyc:2.4.1.175-RXN xref: MetaCyc:RXN-16325 is_a: GO:0008376 ! acetylgalactosaminyltransferase activity @@ -287596,6 +287807,7 @@ synonym: "UDP-N-acetyl-D-mannosamine:N-acetyl-beta-D-glucosaminyldiphosphoundeca synonym: "UDP-N-acetylmannosamine:N-acetylglucosaminyl diphosphorylundecaprenol N-acetylmannosaminyltransferase activity" RELATED [EC:2.4.1.187] synonym: "uridine diphosphoacetyl-mannosamineacetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminyltransferase activity" RELATED [EC:2.4.1.187] xref: EC:2.4.1.187 +xref: MetaCyc:2.4.1.187-RXN xref: MetaCyc:TEICHOICSYN2-RXN xref: RHEA:16053 is_a: GO:0008194 ! UDP-glycosyltransferase activity @@ -287754,6 +287966,7 @@ synonym: "UDP-glucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-gl synonym: "UDPglucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity" RELATED [EC:2.4.1.202] synonym: "uridine diphosphoglucose-2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-glucosyltransferase activity" RELATED [EC:2.4.1.202] xref: EC:2.4.1.202 +xref: MetaCyc:2.4.1.202-RXN xref: MetaCyc:RXN-7022 xref: RHEA:15541 is_a: GO:0035251 ! UDP-glucosyltransferase activity @@ -287935,6 +288148,7 @@ synonym: "UDP-glucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activit synonym: "UDPglucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.53] synonym: "uridine diphosphoglucose-poly(ribitol-phosphate) beta-glucosyltransferase activity" RELATED [EC:2.4.1.53] xref: EC:2.4.1.53 +xref: MetaCyc:2.4.1.53-RXN xref: MetaCyc:RXN-18017 xref: RHEA:10068 is_a: GO:0035251 ! UDP-glucosyltransferase activity @@ -287973,6 +288187,7 @@ synonym: "UDP-N-acetyl-D-glucosamine:poly(ribitol-phosphate) N-acetyl-D-glucosam synonym: "uridine diphosphoacetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.70] xref: EC:2.4.1.70 xref: MetaCyc:2.4.1.53-RXN +xref: MetaCyc:2.4.1.70-RXN xref: RHEA:21012 is_a: GO:0008375 ! acetylglucosaminyltransferase activity @@ -288093,6 +288308,7 @@ synonym: "uridine diphosphogalactose-galactosylacetylglucosaminylgalactosyl-gluc synonym: "uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase activity" RELATED [EC:2.4.1.87] xref: EC:2.4.1.87 xref: MetaCyc:2.4.1.151-RXN +xref: MetaCyc:2.4.1.87-RXN xref: RHEA:13013 is_a: GO:0035250 ! UDP-galactosyltransferase activity @@ -289318,6 +289534,7 @@ synonym: "teichoate synthase activity" RELATED [EC:2.7.8.14] synonym: "teichoate synthetase activity" RELATED [EC:2.7.8.14] synonym: "teichoic-acid synthase activity" BROAD [EC:2.7.8.14] xref: EC:2.7.8.14 +xref: MetaCyc:2.7.8.14-RXN xref: MetaCyc:RXN-18380 xref: RHEA:13353 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups @@ -290004,6 +290221,7 @@ namespace: molecular_function def: "Catalysis of the reaction: H2O + beta-D-Gal-(1,3)-beta-D-GlcNAc-(1,3)-beta-D-Gal-(1,4)-D-Glc = beta-D-Gal-(1,4)-D-Glc + beta-D-Gal-(1,3)-D-GlcNAc." [EC:3.2.1.140, MetaCyc:3.2.1.140-RXN] synonym: "oligosaccharide lacto-N-biosylhydrolase activity" RELATED [EC:3.2.1.140] xref: EC:3.2.1.140 +xref: MetaCyc:3.2.1.140-RXN xref: RHEA:21568 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds @@ -290016,6 +290234,7 @@ synonym: "3-D-glucuronsyl-2-N,6-disulfo-beta-D-glucosamine glucuronohydrolase ac synonym: "3-D-glucuronsyl-N2,6-disulfo-beta-D-glucosamine glucuronohydrolase activity" RELATED [EC:3.2.1.56] synonym: "glucuronosyl-disulphoglucosamine glucuronidase activity" EXACT [] xref: EC:3.2.1.56 +xref: MetaCyc:3.2.1.56-RXN xref: MetaCyc:RXN-16484 xref: RHEA:15073 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds @@ -290934,6 +291153,7 @@ def: "Catalysis of the reaction: glucose-1-phosphate = glucose-6-phosphate; usin synonym: "alpha-D-glucose 1,6-phosphomutase (glucose-cofactor)" RELATED [EC:5.4.2.5] synonym: "glucose-1-phosphate phosphotransferase activity" RELATED [EC:5.4.2.5] xref: EC:5.4.2.5 +xref: MetaCyc:5.4.2.5-RXN xref: MetaCyc:RXN-16999 is_a: GO:0004614 ! phosphoglucomutase activity @@ -291619,6 +291839,7 @@ synonym: "uridine diphosphoxylose-1,4-beta-xylan xylosyltransferase activity" RE synonym: "xylan synthase activity" RELATED [EC:2.4.2.24] synonym: "xylan synthetase activity" RELATED [EC:2.4.2.24] xref: EC:2.4.2.24 +xref: MetaCyc:1\,4-BETA-D-XYLAN-SYNTHASE-RXN xref: MetaCyc:RXN-9104 xref: RHEA:15289 is_a: GO:0008194 ! UDP-glycosyltransferase activity @@ -291720,6 +291941,7 @@ synonym: "2'-hydroxydihydrodaidzein:NADP+ 2'-oxidoreductase activity" RELATED [E synonym: "HDR activity" RELATED [EC:1.3.1.51] synonym: "NADPH:2'-hydroxydaidzein oxidoreductase activity" RELATED [EC:1.3.1.51] xref: EC:1.3.1.51 +xref: MetaCyc:2'-HYDROXYDAIDZEIN-REDUCTASE-RXN xref: MetaCyc:RXN-4502 xref: RHEA:17145 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor @@ -291747,6 +291969,7 @@ synonym: "2,3-dihydroxybenzoate:L-serine ligase activity" RELATED [EC:6.3.2.14] synonym: "2,3-dihydroxybenzoylserine synthetase activity" RELATED [EC:6.3.2.14] synonym: "N-(2,3-dihydroxybenzoyl)-serine synthetase activity" RELATED [EC:6.3.2.14] xref: EC:6.3.2.14 +xref: MetaCyc:1\,3-DIHYDROXYBENZOATE--SERINE-LIGASE-RXN xref: MetaCyc:ENTMULTI-RXN xref: RHEA:30571 is_a: GO:0016881 ! acid-amino acid ligase activity @@ -292418,6 +292641,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 4-acetamidobutanoate + H2O = acetate + 4-aminobutanoate." [EC:3.5.1.63, MetaCyc:4-ACETAMIDOBUTYRATE-DEACETYLASE-RXN] synonym: "4-acetamidobutanoate amidohydrolase activity" RELATED [EC:3.5.1.63] xref: EC:3.5.1.63 +xref: MetaCyc:4-ACETAMIDOBUTYRATE-DEACETYLASE-RXN xref: MetaCyc:RXN-36 xref: RHEA:15897 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides @@ -293118,6 +293342,7 @@ synonym: "adenine nucleotide deaminase activity" RELATED [EC:3.5.4.17] synonym: "adenosine (phosphate) deaminase activity" RELATED [EC:3.5.4.17] synonym: "adenosine-phosphate aminohydrolase activity" RELATED [EC:3.5.4.17] xref: EC:3.5.4.17 +xref: MetaCyc:ADENOSINE-PHOSPHATE-DEAMINASE-RXN is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity @@ -293226,6 +293451,7 @@ synonym: "ADPR-PPase activity" EXACT [] synonym: "ADPribose diphosphatase activity" RELATED [EC:3.6.1.13] synonym: "ADPribose pyrophosphatase activity" RELATED [EC:3.6.1.13] xref: EC:3.6.1.13 +xref: MetaCyc:ADP-RIBOSE-PYROPHOSPHATASE-RXN xref: MetaCyc:RXN0-1441 xref: RHEA:10412 is_a: GO:0016462 ! pyrophosphatase activity @@ -294568,6 +294794,7 @@ synonym: "sucrose 1-fructosyl transferase activity" RELATED [EC:2.4.1.9] synonym: "sucrose 1-fructosyltransferase activity" RELATED [EC:2.4.1.9] synonym: "sucrose:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity" RELATED [EC:2.4.1.9] xref: EC:2.4.1.9 +xref: MetaCyc:INULOSUCRASE-RXN xref: MetaCyc:RXN-15518 xref: RHEA:15745 is_a: GO:0016758 ! hexosyltransferase activity @@ -295099,6 +295326,7 @@ synonym: "caffeate methyltransferase activity" RELATED [EC:2.1.1.68] synonym: "S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase activity" RELATED [EC:2.1.1.68] synonym: "S-adenosyl-L-methionine:caffeic acid-O-methyltransferase activity" RELATED [EC:2.1.1.68] xref: EC:2.1.1.68 +xref: MetaCyc:CAFFEATE-O-METHYLTRANSFERASE-RXN xref: MetaCyc:RXN-1104 xref: RHEA:20225 is_a: GO:0008171 ! O-methyltransferase activity @@ -295527,6 +295755,7 @@ synonym: "uridine diphosphoglucose-cyanohydrin glucosyltransferase activity" REL synonym: "uridine diphosphoglucose-p-hydroxymandelonitrile glucosyltransferase activity" RELATED [EC:2.4.1.85] synonym: "uridine diphosphoglucose:aldehyde cyanohydrin beta-glucosyltransferase activity" RELATED [EC:2.4.1.85] xref: EC:2.4.1.85 +xref: MetaCyc:CYANOHYDRIN-BETA-GLUCOSYLTRANSFERASE-RXN xref: RHEA:12853 is_a: GO:0035251 ! UDP-glucosyltransferase activity @@ -297011,6 +297240,7 @@ synonym: "cannizzanase activity" RELATED [EC:1.2.98.1] synonym: "formaldehyde:formaldehyde oxidoreductase activity" RELATED [EC:1.2.98.1] synonym: "nicotinoprotein aldehyde dismutase" RELATED [EC:1.2.98.1] xref: EC:1.2.98.1 +xref: MetaCyc:FORMALDEHYDE-DISMUTASE-RXN xref: MetaCyc:RXN-11453 xref: RHEA:19221 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors @@ -297511,6 +297741,7 @@ synonym: "D-glucosaminic acid dehydrase activity" RELATED [EC:4.3.1.9] synonym: "glucosaminic dehydrase activity" RELATED [EC:4.3.1.9] xref: EC:4.3.1.9 xref: MetaCyc:4.3.1.21-RXN +xref: MetaCyc:GLUCOSAMINATE-AMMONIA-LYASE-RXN xref: RHEA:12488 is_a: GO:0016841 ! ammonia-lyase activity @@ -298211,6 +298442,7 @@ namespace: molecular_function def: "Catalysis of the reaction: hexose + O2 = aldono-1,5-lactone + H202." [EC:1.1.3.5, MetaCyc:HEXOSE-OXIDASE-RXN] synonym: "D-hexose:oxygen 1-oxidoreductase activity" RELATED [EC:1.1.3.5] xref: EC:1.1.3.5 +xref: MetaCyc:HEXOSE-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] @@ -298470,6 +298702,7 @@ def: "Catalysis of the reaction: formononetin + NADPH + O2 = calycosin + NADP+ + synonym: "formononetin,NADPH:oxygen oxidoreductase (3'-hydroxylating)" RELATED [EC:1.14.14.88] synonym: "isoflavone 3'-monooxygenase activity" RELATED [EC:1.14.14.88] xref: EC:1.14.14.88 +xref: MetaCyc:ISOFLAVONE-3'-HYDROXYLASE-RXN xref: MetaCyc:RXN-3762 xref: RHEA:22960 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen @@ -311606,6 +311839,7 @@ synonym: "sucrose:sucrose 1F-beta-D-fructosyltransferase activity" RELATED [EC:2 synonym: "sucrose:sucrose fructosyltransferase activity" RELATED [EC:2.4.1.99] xref: EC:2.4.1.99 xref: MetaCyc:RXN-1781 +xref: MetaCyc:SUCROSE-1F-FRUCTOSYLTRANSFERASE-RXN xref: RHEA:23312 is_a: GO:0050738 ! fructosyltransferase activity @@ -311643,6 +311877,7 @@ def: "Catalysis of the reaction: H2O + sugar phosphorylated on the terminal carb synonym: "sugar-omega-phosphate phosphohydrolase activity" EXACT systematic_synonym [EC:3.1.3.58] synonym: "xylitol-5-phosphatase activity" NARROW [EC:3.1.3.58] xref: EC:3.1.3.58 +xref: MetaCyc:SUGAR-TERMINAL-PHOSPHATASE-RXN is_a: GO:0050308 ! sugar-phosphatase activity [Term] @@ -311730,6 +311965,7 @@ def: "Catalysis of the reactions: ATP + dGMP = ADP + dGDP, and ATP + dTMP = ADP synonym: "ATP:(d)NMP phosphotransferase activity" RELATED [EC:2.7.4.12] xref: EC:2.7.4.12 xref: MetaCyc:GMKALT-RXN +xref: MetaCyc:T2-INDUCED-DEOXYNUCLEOTIDE-KINASE-RXN xref: RHEA:12697 is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor @@ -312212,6 +312448,7 @@ synonym: "resveratrol synthase activity" RELATED [EC:2.3.1.95] synonym: "stilbene synthase activity" BROAD [EC:2.3.1.95] xref: EC:2.3.1.95 xref: MetaCyc:RXN-87 +xref: MetaCyc:TRIHYDROXYSTILBENE-SYNTHASE-RXN xref: RHEA:11936 is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups @@ -312504,6 +312741,7 @@ synonym: "tyrosine 3-monooxygenase kinase (phosphorylating) activity" RELATED [E synonym: "tyrosine 3-monooxygenase kinase activity" EXACT [] xref: EC:2.7.11.6 xref: MetaCyc:2.7.11.6-RXN +xref: MetaCyc:TYROSINE-3-MONOOXYGENASE-KINASE-RXN xref: RHEA:17133 intersection_of: GO:0004674 ! protein serine/threonine kinase activity intersection_of: has_primary_input PR:000016301 ! tyrosine 3-monooxygenase @@ -312951,6 +313189,7 @@ synonym: "xylono-g-lactonase activity" RELATED [EC:3.1.1.68] synonym: "xylonolactonase activity" RELATED [EC:3.1.1.68] xref: EC:3.1.1.68 xref: MetaCyc:RXN-19753 +xref: MetaCyc:XYLONO-14-LACTONASE-RXN xref: RHEA:18341 is_a: GO:0052689 ! carboxylic ester hydrolase activity @@ -313184,6 +313423,7 @@ synonym: "L-glutamine(L-asparagine) amidohydrolase activity" RELATED [EC:3.5.1.3 xref: EC:3.5.1.38 xref: MetaCyc:ASPARAGHYD-RXN {source="skos:broadMatch"} xref: MetaCyc:GLUTAMIN-RXN {source="skos:broadMatch"} +xref: MetaCyc:GLUTAMINASE-ASPARAGIN-ASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28176" xsd:anyURI @@ -314446,6 +314686,7 @@ synonym: "alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucu synonym: "chondroitin glucuronyltransferase II activity" RELATED [EC:2.4.1.226] synonym: "N-acetylgalactosaminyl-proteoglycan 3-b-glucuronosyltransferase activity" EXACT [] xref: EC:2.4.1.226 +xref: MetaCyc:2.4.1.226-RXN xref: MetaCyc:RXN-16324 is_a: GO:0015020 ! glucuronosyltransferase activity @@ -315530,6 +315771,7 @@ synonym: "leucoanthocyanidin dioxygenase activity" RELATED [EC:1.14.20.4] synonym: "leucoanthocyanidin hydroxylase" RELATED [EC:1.14.20.4] synonym: "leucocyanidin,2-oxoglutarate:oxygen oxidoreductase activity" RELATED [EC:1.14.20.4] xref: EC:1.14.20.4 +xref: MetaCyc:1.14.11.19-RXN xref: MetaCyc:RXN-602 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity @@ -317512,6 +317754,7 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose (out) = galactose(in)." [GOC:ai, TC:2.A.1.1.6] synonym: "galactose, glucose uniporter activity" BROAD [] xref: RHEA:34915 {source="skos:broadMatch"} +xref: TC:2.A.1.1.6 is_a: GO:0005354 ! galactose transmembrane transporter activity is_a: GO:0008516 ! hexose uniporter activity property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27521" xsd:anyURI @@ -339130,6 +339373,7 @@ id: GO:0052776 name: diacetylchitobiose catabolic process to glucosamine and acetate namespace: biological_process def: "The pathway resulting in the breakdown of diacetylchitobiose into simpler products, including glucosamine and glucosamine. The catabolism proceeds by the deacetylation of diacetylchitobiose, producing acetate and GlcN-GlcNAc; the latter is cleaved to produce glucosamine (GlcN) and N-acetylglucosamine (GlcNAc). The N-acetylglucosamine (GlcNAc) is then deacetylated to produce glucosamine (GlcN) and acetate." [GOC:bf, GOC:mengo_curators, MetaCyc:PWY-6855, PMID:15136574, PMID:16232910, PMID:16736587] +xref: MetaCyc:PWY-6855 intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:28681 ! N,N'-diacetylchitobiose intersection_of: has_primary_output CHEBI:30089 ! acetate @@ -360399,6 +360643,7 @@ id: GO:0061681 name: Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate namespace: biological_process def: "The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde-3-phosphate." [GOC:dph, MetaCyc:ENTNER-DOUFDOROFF-PWY-III, PMID:12921536] +xref: MetaCyc:ENTNER-DOUFDOROFF-PWY-III xref: MetaCyc:PWY-2221 is_a: GO:0061679 ! Entner-Doudoroff pathway through gluconate intersection_of: GO:0061679 ! Entner-Doudoroff pathway through gluconate @@ -408255,6 +408500,7 @@ id: GO:0090439 name: tetraketide alpha-pyrone synthase activity namespace: molecular_function def: "Catalyzes the reaction: 7-hydroxylauroyl-CoA + 3 malonyl-CoA + 2 H+ = 2-(8-hydroxy-2-oxotridecyl)-6-oxopyran-4-olate + 3 CO2 + 4 coenzyme A." [MetaCyc:RXN-12183, PMID:21193570] +xref: MetaCyc:RXN-12183 xref: MetaCyc:RXN-16407 {source="skos:exactMatch"} is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28324" xsd:anyURI @@ -409384,6 +409630,7 @@ synonym: "ATP-dependent phosphatidylethanolamine transporter activity" RELATED [ synonym: "ATPase-coupled phosphatidylethanolamine transporter activity" BROAD [] synonym: "phosphatidylethanolamine flippase activity (exoplasmic to cytosolic leaflet)" EXACT [] synonym: "phosphatidylethanolamine-translocating ATPase activity" RELATED [] +xref: RHEA:36439 xref: RHEA:66132 intersection_of: GO:0140327 ! flippase activity intersection_of: has_primary_input CHEBI:57613 ! phosphatidylethanolamine zwitterion @@ -410225,6 +410472,7 @@ id: GO:0090638 name: phosphatidylcholine biosynthesis from phosphatidylethanolamine namespace: biological_process def: "The phosphatidylcholine biosynthetic process that depends on direct conversion of the phosphatidyl-base phosphatidylethanolamine to phosphatidylcholine by successive methylations." [MetaCyc:PWY-6825] +xref: MetaCyc:PWY-6825 is_a: GO:0006656 ! phosphatidylcholine biosynthetic process created_by: tb creation_date: 2015-04-23T15:56:12Z @@ -410234,6 +410482,7 @@ id: GO:0090639 name: phosphatidylcholine biosynthesis from choline and CDP-diacylglycerol namespace: biological_process def: "The phosphatidylcholine biosynthetic process that involves a one-step direct condensation of choline with CDP-diacylglycerol to form phosphatidylcholine." [MetaCyc:PWY-6826] +xref: MetaCyc:PWY-6826 is_a: GO:0006656 ! phosphatidylcholine biosynthetic process created_by: tb creation_date: 2015-04-23T15:56:12Z @@ -410243,6 +410492,7 @@ id: GO:0090640 name: phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine namespace: biological_process def: "The phosphatidylcholine biosynthetic process that involves the two-step acylation of sn-glycero-3-phosphocholine to a phosphatidylcholine." [MetaCyc:PWY-7470, PMID:24329598, PMID:27758859] +xref: MetaCyc:PWY-7470 is_a: GO:0006656 ! phosphatidylcholine biosynthetic process created_by: tb creation_date: 2015-04-23T15:56:12Z @@ -414212,6 +414462,7 @@ name: leukotriene B4 12-hydroxy dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: leukotriene B4 + NADP+ = 12-oxo-leukotriene B4 + NADPH + H+." [GOC:mw, KEGG_REACTION:R03864, PMID:8394361, PMID:9461497] synonym: "leukotriene B4 12-hydroxydehydrogenase activity" EXACT [] +xref: KEGG_REACTION:R03864 xref: RHEA:50608 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors created_by: pr @@ -414629,6 +414880,7 @@ synonym: "'de novo' XMP anabolism" EXACT [] synonym: "'de novo' XMP biosynthesis" EXACT [] synonym: "'de novo' XMP formation" EXACT [] synonym: "'de novo' XMP synthesis" EXACT [] +xref: MetaCyc:IMP-DEHYDROG-RXN is_a: GO:0097293 ! XMP biosynthetic process created_by: pr creation_date: 2012-04-26T09:57:49Z @@ -430551,6 +430803,7 @@ id: GO:0102115 name: peptidoglycan asparagine synthase activity namespace: molecular_function def: "Catalysis of the reaction: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparatyl)-L-lysyl-D-alanyl-D-alanine + ammonium + ATP = H+ + ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparaginyl)-L-lysyl-D-alanyl-D-alanine + AMP + diphosphoric acid." [EC:6.3.1.-, GOC:pz] +xref: EC:6.3.1.- xref: MetaCyc:RXN-11338 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity @@ -430772,6 +431025,7 @@ id: GO:0102140 name: heparan sulfate N-deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + [heparan sulfate]-N-acetyl-alpha-D-glucosamine = acetate + H+ + [heparan sulfate]-alpha-D-glucosamine." [EC:3.1.1.-, GOC:pz] +xref: EC:3.1.1.- xref: MetaCyc:RXN-11557 is_a: GO:0019213 ! deacetylase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity @@ -431946,6 +432200,7 @@ id: GO:0102274 name: glutathione S-conjugate carboxypeptidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a glutathione-toxin conjugate = glycine + a [Glu-Cys]-S-conjugate." [EC:3.4.17.-, GOC:pz] +xref: EC:3.4.17.- xref: MetaCyc:RXN-12532 is_a: GO:0004181 ! metallocarboxypeptidase activity @@ -432294,6 +432549,7 @@ id: GO:0102310 name: dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate 3-ketoreductase (dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose-forming) activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose + NAD(P) = dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate + 2 H+ + NAD(P)H." [EC:1.17.1.-, GOC:pz] +xref: EC:1.17.1.- xref: MetaCyc:RXN-12940 is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor @@ -434468,6 +434724,7 @@ id: GO:0102544 name: ornaline synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithinium(1+) + 2-oxoglutarate + NADPH + H+ = ornaline + NADP + H2O." [EC:1.5.1.-, GOC:pz] +xref: EC:1.5.1.- xref: MetaCyc:RXN-14880 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor @@ -438916,6 +439173,7 @@ id: GO:0103028 name: murein hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: a peptidoglycan dimer (generic) = a lipid II + GlcNAc-1,6-anhydro-MurNAc-pentapeptide." [EC:4.2.2.-, GOC:pz] +xref: EC:4.2.2.- xref: MetaCyc:RXN0-5190 is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides @@ -438933,6 +439191,7 @@ id: GO:0103031 name: L-Ala-D/L-Glu epimerase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanyl-D-glutamate = L-alanyl-L-glutamate." [EC:5.1.1.-, GOC:pz] +xref: EC:5.1.1.- xref: MetaCyc:RXN0-5228 xref: RHEA:28394 is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives @@ -438952,6 +439211,7 @@ id: GO:0103033 name: beta-galactosidase activity (lactose isomerization) namespace: molecular_function def: "Catalysis of the reaction: alpha-lactose = beta-(1->6)-galactobiose." [EC:5.4.1.-, GOC:pz] +xref: EC:5.4.1.- xref: MetaCyc:RXN0-5363 is_a: GO:0016867 ! intramolecular acyltransferase activity @@ -439006,6 +439266,7 @@ id: GO:0103041 name: thiosulfate-thioredoxin sulfurtransferase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxidodioxidosulfidosulfate + a reduced thioredoxin = sulfite + hydrogen sulfide + H+ + an oxidized thioredoxin." [EC:2.8.1.-, GOC:pz] +xref: EC:2.8.1.- xref: MetaCyc:RXN0-6385 is_a: GO:0016783 ! sulfurtransferase activity @@ -439251,6 +439512,7 @@ id: GO:0103072 name: straight chain (R)-2-hydroxy fatty acyl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: a (R)-2-hydroxy even numbered straight chain 2,3,4-saturated fatty acyl CoA = formyl-CoA + an odd numbered straight chain 2,3,4-saturated fatty aldehyde." [EC:4.1.-.-, GOC:pz] +xref: EC:4.1.-.- xref: MetaCyc:RXN66-475 is_a: GO:0016830 ! carbon-carbon lyase activity @@ -452333,7 +452595,6 @@ synonym: "down regulation of septin assembly and septum formation involved in mi synonym: "down-regulation of division septum formation involved in mitotic cell cycle" EXACT [] synonym: "down-regulation of formation of division septum involved in mitotic cell cycle" EXACT [] synonym: "down-regulation of mitotic division septum assembly" EXACT [] -synonym: "down-regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [] synonym: "down-regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "down-regulation of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "downregulation of division septum formation involved in mitotic cell cycle" EXACT [] @@ -458665,6 +458926,7 @@ synonym: "medicarpan synthase activity" EXACT [EC:4.2.1.139] synonym: "medicarpin synthase activity" EXACT [EC:4.2.1.139] xref: EC:4.2.1.139 xref: RHEA:35407 +xref: RHEA:35811 is_a: GO:0016836 ! hydro-lyase activity property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/23521" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28937" xsd:anyURI @@ -489002,6 +489264,7 @@ name: neomycin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving neomycin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-7016, UniPathway:UPA00969] synonym: "neomycin metabolism" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-7016 intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:7507 ! neomycin created_by: yaf @@ -489015,6 +489278,7 @@ def: "The chemical reactions and pathways resulting in the breakdown of neomycin synonym: "neomycin breakdown" EXACT [GOC:TermGenie] synonym: "neomycin catabolism" EXACT [GOC:TermGenie] synonym: "neomycin degradation" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-7016 intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:7507 ! neomycin created_by: yaf @@ -489029,6 +489293,7 @@ synonym: "neomycin anabolism" EXACT [GOC:TermGenie] synonym: "neomycin biosynthesis" EXACT [GOC:TermGenie] synonym: "neomycin formation" EXACT [GOC:TermGenie] synonym: "neomycin synthesis" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-7016 intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:7507 ! neomycin created_by: yaf @@ -499438,6 +499703,7 @@ synonym: "lincomycin anabolism" EXACT [GOC:TermGenie] synonym: "lincomycin biosynthesis" EXACT [GOC:TermGenie] synonym: "lincomycin formation" EXACT [GOC:TermGenie] synonym: "lincomycin synthesis" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-6955 intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:6472 ! lincomycin created_by: yaf @@ -499514,6 +499780,7 @@ synonym: "pentalenolactone anabolism" EXACT [GOC:TermGenie] synonym: "pentalenolactone biosynthesis" EXACT [GOC:TermGenie] synonym: "pentalenolactone formation" EXACT [GOC:TermGenie] synonym: "pentalenolactone synthesis" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-6915 intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:70790 ! pentalenolactone(1-) created_by: yaf @@ -499538,6 +499805,7 @@ def: "The chemical reactions and pathways resulting in the breakdown of p-cumate synonym: "p-cumate breakdown" EXACT [GOC:TermGenie] synonym: "p-cumate catabolism" EXACT [GOC:TermGenie] synonym: "p-cumate degradation" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-5273 intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:25822 ! p-cumate created_by: yaf @@ -499614,6 +499882,9 @@ def: "The chemical reactions and pathways resulting in the breakdown of benzoyl- synonym: "benzoyl-CoA breakdown" EXACT [GOC:TermGenie] synonym: "benzoyl-CoA catabolism" EXACT [GOC:TermGenie] synonym: "benzoyl-CoA degradation" EXACT [GOC:TermGenie] +xref: MetaCyc:CENTBENZCOA-PWY +xref: MetaCyc:P321-PWY +xref: MetaCyc:PWY-1361 intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:57369 ! benzoyl-CoA(4-) created_by: yaf @@ -499639,6 +499910,7 @@ name: 3-(2,3-dihydroxyphenyl)propanoate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-(2,3-dihydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, MetaCyc:HCAMHPDEG-PWY] synonym: "3-(2,3-dihydroxyphenyl)propanoate metabolism" EXACT [GOC:TermGenie] +xref: MetaCyc:HCAMHPDEG-PWY intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:46951 ! 3-(2,3-dihydroxyphenyl)propanoate property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28776" xsd:anyURI @@ -499653,6 +499925,7 @@ def: "The chemical reactions and pathways resulting in the breakdown of 3-(2,3-d synonym: "3-(2,3-dihydroxyphenyl)propanoate breakdown" EXACT [GOC:TermGenie] synonym: "3-(2,3-dihydroxyphenyl)propanoate catabolism" EXACT [GOC:TermGenie] synonym: "3-(2,3-dihydroxyphenyl)propanoate degradation" EXACT [GOC:TermGenie] +xref: MetaCyc:HCAMHPDEG-PWY intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:46951 ! 3-(2,3-dihydroxyphenyl)propanoate property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28388" xsd:anyURI @@ -499695,6 +499968,7 @@ def: "The chemical reactions and pathways resulting in the breakdown of 3-(3-hyd synonym: "3-(3-hydroxyphenyl)propanoate breakdown" EXACT [GOC:TermGenie] synonym: "3-(3-hydroxyphenyl)propanoate catabolism" EXACT [GOC:TermGenie] synonym: "3-(3-hydroxyphenyl)propanoate degradation" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY0-1277 intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:57277 ! 3-(3-hydroxyphenyl)propanoate created_by: yaf @@ -499806,6 +500080,7 @@ name: 1,5-anhydro-D-fructose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,5-anhydro-D-fructose." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6992, PMID:15716041, UniPathway:UPA00738] synonym: "1,5-anhydro-D-fructose metabolism" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-6992 intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:16715 ! 1,5-anhydro-D-fructose created_by: yaf @@ -499819,6 +500094,7 @@ def: "The chemical reactions and pathways resulting in the breakdown of 1,5-anhy synonym: "1,5-anhydro-D-fructose breakdown" EXACT [GOC:TermGenie] synonym: "1,5-anhydro-D-fructose catabolism" EXACT [GOC:TermGenie] synonym: "1,5-anhydro-D-fructose degradation" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-6992 intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:16715 ! 1,5-anhydro-D-fructose created_by: yaf @@ -499833,6 +500109,7 @@ synonym: "1,5-anhydro-D-fructose anabolism" EXACT [GOC:TermGenie] synonym: "1,5-anhydro-D-fructose biosynthesis" EXACT [GOC:TermGenie] synonym: "1,5-anhydro-D-fructose formation" EXACT [GOC:TermGenie] synonym: "1,5-anhydro-D-fructose synthesis" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-6992 intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:16715 ! 1,5-anhydro-D-fructose created_by: yaf @@ -499885,6 +500162,7 @@ name: capsanthin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving capsanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, PMID:10995282, UniPathway:UPA00806] synonym: "capsanthin metabolism" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-5174 intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:3375 ! capsanthin created_by: yaf @@ -499898,6 +500176,7 @@ def: "The chemical reactions and pathways resulting in the breakdown of capsanth synonym: "capsanthin breakdown" EXACT [GOC:TermGenie] synonym: "capsanthin catabolism" EXACT [GOC:TermGenie] synonym: "capsanthin degradation" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-5174 intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:3375 ! capsanthin created_by: yaf @@ -499912,6 +500191,7 @@ synonym: "capsanthin anabolism" EXACT [GOC:TermGenie] synonym: "capsanthin biosynthesis" EXACT [GOC:TermGenie] synonym: "capsanthin formation" EXACT [GOC:TermGenie] synonym: "capsanthin synthesis" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-5174 intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:3375 ! capsanthin created_by: yaf @@ -499923,6 +500203,7 @@ name: beta-carotene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5943, PMID:11387982, UniPathway:UPA00802] synonym: "beta-carotene metabolism" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-5943 intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:17579 ! beta-carotene created_by: yaf @@ -499936,6 +500217,7 @@ def: "The chemical reactions and pathways resulting in the breakdown of beta-car synonym: "beta-carotene breakdown" EXACT [GOC:TermGenie] synonym: "beta-carotene catabolism" EXACT [GOC:TermGenie] synonym: "beta-carotene degradation" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-5943 intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:17579 ! beta-carotene created_by: yaf @@ -499950,6 +500232,7 @@ synonym: "beta-carotene anabolism" EXACT [GOC:TermGenie] synonym: "beta-carotene biosynthesis" EXACT [GOC:TermGenie] synonym: "beta-carotene formation" EXACT [GOC:TermGenie] synonym: "beta-carotene synthesis" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-5943 intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:17579 ! beta-carotene created_by: yaf @@ -499961,6 +500244,7 @@ name: astaxanthin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving astaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5288, PMID:16434154, UniPathway:UPA00387] synonym: "astaxanthin metabolism" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-5288 intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:40968 ! astaxanthin created_by: yaf @@ -499974,6 +500258,7 @@ def: "The chemical reactions and pathways resulting in the breakdown of astaxant synonym: "astaxanthin breakdown" EXACT [GOC:TermGenie] synonym: "astaxanthin catabolism" EXACT [GOC:TermGenie] synonym: "astaxanthin degradation" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-5288 intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:40968 ! astaxanthin created_by: yaf @@ -499988,6 +500273,7 @@ synonym: "astaxanthin anabolism" EXACT [GOC:TermGenie] synonym: "astaxanthin biosynthesis" EXACT [GOC:TermGenie] synonym: "astaxanthin formation" EXACT [GOC:TermGenie] synonym: "astaxanthin synthesis" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-5288 intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:40968 ! astaxanthin created_by: yaf @@ -500075,6 +500361,7 @@ name: delta-carotene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving delta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5946, PMID:8837512, UniPathway:UPA00801] synonym: "delta-carotene metabolism" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-5946 intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:27705 ! delta-carotene created_by: yaf @@ -500088,6 +500375,7 @@ def: "The chemical reactions and pathways resulting in the breakdown of delta-ca synonym: "delta-carotene breakdown" EXACT [GOC:TermGenie] synonym: "delta-carotene catabolism" EXACT [GOC:TermGenie] synonym: "delta-carotene degradation" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-5946 intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:27705 ! delta-carotene created_by: yaf @@ -500102,6 +500390,7 @@ synonym: "delta-carotene anabolism" EXACT [GOC:TermGenie] synonym: "delta-carotene biosynthesis" EXACT [GOC:TermGenie] synonym: "delta-carotene formation" EXACT [GOC:TermGenie] synonym: "delta-carotene synthesis" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-5946 intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:27705 ! delta-carotene created_by: yaf @@ -500113,6 +500402,7 @@ name: zeaxanthin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving zeaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5944, UniPathway:UPA00843] synonym: "zeaxanthin metabolism" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-5944 intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:27547 ! zeaxanthin created_by: yaf @@ -500126,6 +500416,7 @@ def: "The chemical reactions and pathways resulting in the breakdown of zeaxanth synonym: "zeaxanthin breakdown" EXACT [GOC:TermGenie] synonym: "zeaxanthin catabolism" EXACT [GOC:TermGenie] synonym: "zeaxanthin degradation" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-5944 intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:27547 ! zeaxanthin created_by: yaf @@ -500140,6 +500431,7 @@ synonym: "zeaxanthin anabolism" EXACT [GOC:TermGenie] synonym: "zeaxanthin biosynthesis" EXACT [GOC:TermGenie] synonym: "zeaxanthin formation" EXACT [GOC:TermGenie] synonym: "zeaxanthin synthesis" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-5944 intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:27547 ! zeaxanthin created_by: yaf @@ -500152,6 +500444,7 @@ namespace: biological_process def: "The chemical reactions and pathways involving zeaxanthin bis(beta-D-glucoside)." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6288, PMID:20075616, UniPathway:UPA00798] synonym: "zeaxanthin bis(beta-D-glucoside) metabolism" EXACT [GOC:TermGenie] synonym: "zeaxanthin diglucoside metabolism" EXACT [GOC:yaf] +xref: MetaCyc:PWY-6288 intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:63067 ! zeaxanthin bis(beta-D-glucoside) created_by: yaf @@ -500168,6 +500461,7 @@ synonym: "zeaxanthin bis(beta-D-glucoside) degradation" EXACT [GOC:TermGenie] synonym: "zeaxanthin diglucoside breakdown" EXACT [GOC:yaf] synonym: "zeaxanthin diglucoside catabolism" EXACT [GOC:yaf] synonym: "zeaxanthin diglucoside degradation" EXACT [GOC:yaf] +xref: MetaCyc:PWY-6288 intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:63067 ! zeaxanthin bis(beta-D-glucoside) created_by: yaf @@ -500186,6 +500480,7 @@ synonym: "zeaxanthin diglucoside anabolism" EXACT [GOC:yaf] synonym: "zeaxanthin diglucoside biosynthesis" EXACT [GOC:yaf] synonym: "zeaxanthin diglucoside formation" EXACT [GOC:yaf] synonym: "zeaxanthin diglucoside synthesis" EXACT [GOC:yaf] +xref: MetaCyc:PWY-6288 intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:63067 ! zeaxanthin bis(beta-D-glucoside) created_by: yaf @@ -500199,6 +500494,7 @@ def: "The chemical reactions and pathways involving all-trans-neoxanthin." [GOC: synonym: "all-trans-neoxanthin metabolism" EXACT [GOC:TermGenie] synonym: "neoxanthin metabolic process" EXACT [GOC:yaf] synonym: "neoxanthin metabolism" EXACT [GOC:yaf] +xref: MetaCyc:PWY-6809 intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:32446 ! all-trans-neoxanthin created_by: yaf @@ -500216,6 +500512,7 @@ synonym: "neoxanthin breakdown" EXACT [GOC:yaf] synonym: "neoxanthin catabolic process" EXACT [GOC:yaf] synonym: "neoxanthin catabolism" EXACT [GOC:yaf] synonym: "neoxanthin degradation" EXACT [GOC:yaf] +xref: MetaCyc:PWY-6809 intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:32446 ! all-trans-neoxanthin created_by: yaf @@ -500235,6 +500532,7 @@ synonym: "neoxanthin biosynthesis" EXACT [GOC:yaf] synonym: "neoxanthin biosynthetic process" EXACT [GOC:yaf] synonym: "neoxanthin formation" EXACT [GOC:yaf] synonym: "neoxanthin synthesis" EXACT [GOC:yaf] +xref: MetaCyc:PWY-6809 intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:32446 ! all-trans-neoxanthin created_by: yaf @@ -500754,6 +501052,7 @@ name: capsorubin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving capsorubin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, UniPathway:UPA00807] synonym: "capsorubin metabolism" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-5174 intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:3378 ! capsorubin created_by: yaf @@ -500767,6 +501066,7 @@ def: "The chemical reactions and pathways resulting in the breakdown of capsorub synonym: "capsorubin breakdown" EXACT [GOC:TermGenie] synonym: "capsorubin catabolism" EXACT [GOC:TermGenie] synonym: "capsorubin degradation" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-5174 intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:3378 ! capsorubin created_by: yaf @@ -500781,6 +501081,7 @@ synonym: "capsorubin anabolism" EXACT [GOC:TermGenie] synonym: "capsorubin biosynthesis" EXACT [GOC:TermGenie] synonym: "capsorubin formation" EXACT [GOC:TermGenie] synonym: "capsorubin synthesis" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-5174 intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:3378 ! capsorubin created_by: yaf @@ -566677,7 +566978,6 @@ namespace: biological_process alt_id: GO:1903128 def: "Any process that modulates the frequency, rate or extent of L-leucine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:10467003] synonym: "regulation of L-leucine import into cell" EXACT [GOC:TermGenie] -synonym: "regulation of L-leucine import into cell" EXACT [] intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:1903801 ! L-leucine import across plasma membrane created_by: vw @@ -566707,7 +567007,6 @@ alt_id: GO:1903130 def: "Any process that activates or increases the frequency, rate or extent of L-leucine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:10467003] synonym: "activation of L-leucine import into cell" NARROW [GOC:TermGenie] synonym: "activation of leucine import into cell" NARROW [GOC:TermGenie] -synonym: "positive regulation of L-leucine import into cell" EXACT [] synonym: "positive regulation of L-leucine import into cell" EXACT [GOC:TermGenie] synonym: "positive regulation of leucine import across plasma membrane" BROAD [] synonym: "up regulation of L-leucine import into cell" EXACT [GOC:TermGenie] @@ -574683,6 +574982,7 @@ id: GO:1990043 name: 5' deoxyribonuclease (pyrimidine dimer) activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage immediately 5' to pyrimidine dimers to products with 5'-phosphate." [EC:3.1.25.-, GOC:al, PMID:9708997] +xref: EC:3.1.25.- is_a: GO:0033892 ! deoxyribonuclease (pyrimidine dimer) activity created_by: pr creation_date: 2013-02-15T12:16:51Z @@ -574840,6 +575140,7 @@ namespace: molecular_function def: "Catalyzes the reaction: L-phenylalanine + O2 + H2O -> phenylacetaldehyde + ammonia + hydrogen peroxide + CO2." [MetaCyc:RXN-8990, PMID:16766535, PMID:23204519] synonym: "aromatic aldehyde synthase" BROAD [] xref: EC:4.1.1.109 +xref: MetaCyc:RXN-8990 xref: RHEA:55532 is_a: GO:0016831 ! carboxy-lyase activity created_by: tb