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******************* Regulatory Event *******************
event('Myelodysplastic Syndromes',association,'CD4')
subject names: : ['myelodysplastic syndromes', 'MDS']
object names: : ['CD4']
Sentences from abstracts:
------------------------
Defective mitogen-induced cellular cytotoxicity in myelodysplastic syndromes. Recovery after alpha-interferon administration. Peripheral blood mitogen - induced cellular cytotoxicity (MICC) and natural killer- cell cytotoxicity (NKCC) were assessed in 25 patients with myelodysplastic syndromes (MDS). Both MICC and NKCC were examined under the same experimental conditions using the 18 hr chromium release assay, except that cultures for MICC were stimulated in vitro by the addition of phytohemagglutinin (PHA). Patients' MICC was found significantly reduced, in relation to controls (p less than 0.001), but significantly higher than patients' NKCC (p less than 0.001). Furthermore, patients CD3+ cells and CD4+ cells, as well as the CD4+/CD8+ ratio, were significantly decreased (p less than 0.01, p less than 0.001 and p less than 0.001, respectively), while CD8+ cells and CD16+ cells were within normal limits. No relationship was noted between patients' MICC and total lymphocyte count or any lymphocyte subpopulation. In eleven patients who were subsequently subjected to a-interferon (a-IFN) administration, MICC values were found within normal range one month after the cessation of alpha-IFN, while NKCC values were significantly increased (p less than 0.01), but they still remained below the lower limit of the control (p less than 0.001). Percentages of CD3+, CD4+ and CD8+ cells, as well as the CD4+/CD8+ ratio, did not change after alpha-IFN, but the absolute numbers of CD3+ cells and CD8+ cells were significantly reduced. A statistically significant rise was noted in CD16+ cells. Post- IFN rises in MICC did not correlate with lymphocyte subpopulations. The findings indicate that MDS patients display very low MICC, which can be restored by alpha-IFN administration. The cause of this disturbance and the mechanism of its restoration by alpha-IFN remain unclear. PUBMED_ID: 2064322
******************* Regulatory Event *******************
event('IFNG',association,'CD8A')
subject names: : ['interferon-gamma', 'IFN-gamma', 'interferon gamma', 'IFNgamma', 'Interferon-gamma', 'interferon (IFN)-gamma']
object names: : ['CD8', 'CD8alpha']
Sentences from abstracts:
------------------------
CD8(+) CTLs (12/18) were detectable by interferon-gamma (IFN-gamma) ELISpot analysis. PUBMED_ID: 12905010
NY-ESO-1-specific immune responses were observed for CD4(+) and CD8(+) T cells from peripheral blood lymphocytes in 4 of 8 neuroblastoma patients, as detected by IFN-gamma enzyme-linked immunospot assay after in vitro stimulation either with the NY-ESO-1 recombinant protein or with the HLA-A2-restricted peptide NY-ESO-1(157-167). PUBMED_ID: 14583496
Peptides selected from either p53-binding region (LTag351-450 and LTag533-626) by current algorithms and capacity to bind HLA-A*0201 molecule were used to stimulate CD8+ T responses, as assessed by IFN-gamma gene expression ex vivo and detected by cytotoxicity assays following in vitro culture. PUBMED_ID: 17096832
******************* Regulatory Event *******************
event('Colorectal Neoplasms',association,'IL2')
subject names: : ['colorectal cancer', 'colorectal carcinoma', 'Colorectal carcinoma', 'colorectal carcinomas']
object names: : ['interleukin-2', 'IL-2', 'interleukin 2', 'interleukin (IL)-2']
Sentences from abstracts:
------------------------
Colorectal carcinoma cells were recognized by survivin-specific T lymphocytes, and the survivin-specific, class-I HLA-restricted T lymphocytes were fully activated and released interleukin-2 in response to HLA/survivin-peptide complexes expressed by tumor cells. PUBMED_ID: 12907624
******************* Regulatory Event *******************
event('Colorectal Neoplasms',association,'CD8A')
subject names: : ['colorectal cancer', 'colorectal carcinoma', 'Colorectal carcinoma', 'colorectal carcinomas']
object names: : ['CD8', 'CD8alpha']
Sentences from abstracts:
------------------------
The apoptosis inhibitor protein survivin induces tumor-specific CD8+ and CD4+ T cells in colorectal cancer patients. PUBMED_ID: 12907624
We assessed infiltration of CD4+, CD8+, CD56+ and CD57+ cells in the tumor epithelium, tumor stroma and advancing tumor margin of 93 colorectal carcinomas and correlated this to clinicopathological parameters, the expression of HLA-A and HLA-B/C on tumor cells, the presence of a basal membrane (BM)-like structure surrounding tumor nodules and the presence of microsatellite instability/mutator phenotype (absent MLH-1 expression). PUBMED_ID: 14968119
We conclude that infiltration of CD8+ and CD57+ cells are important prognostic factors in colorectal cancer. PUBMED_ID: 14968119
******************* Regulatory Event *******************
event('NEOPLASMS',association,'CD8A')
subject names: : ['tumor', 'neoplasia', 'cancer', 'tumors', 'tumor antigen', 'Tumor', 'cancers', 'haematological malignancies', 'neoplastic', 'necrotic tumors', 'cancer metastasis', 'malignancies', 'gynecologic cancers', 'Cancer', 'luminal-type tumors']
object names: : ['CD8', 'CD8alpha']
Sentences from abstracts:
------------------------
The apoptosis inhibitor protein survivin induces tumor-specific CD8+ and CD4+ T cells in colorectal cancer patients. PUBMED_ID: 12907624
In particular, we found that survivin elicited CD8(+) T cell-mediated responses in peripheral blood or in tumor-associated lymphocytes from patients at different disease stage. PUBMED_ID: 12907624
Vaccination with class I tumor peptides has been performed to induce tumor-reactive CD8(+) T cells in vivo. PUBMED_ID: 14764741
We assessed infiltration of CD4+, CD8+, CD56+ and CD57+ cells in the tumor epithelium, tumor stroma and advancing tumor margin of 93 colorectal carcinomas and correlated this to clinicopathological parameters, the expression of HLA-A and HLA-B/C on tumor cells, the presence of a basal membrane (BM)-like structure surrounding tumor nodules and the presence of microsatellite instability/mutator phenotype (absent MLH-1 expression). PUBMED_ID: 14968119
The median intraepithelial CD4+, CD8+, CD56+ and CD57+ cell infiltrations were 3, 23, 0 and 0 cells/mm(2) tumor, respectively. PUBMED_ID: 14968119
Uni- and multivariate analyses showed that a lower tumor stage (P=0.004) and marked infiltration of CD8+ (P=0.04) and CD57+ cells (P=0.05) at the advancing tumor margin were independent prognostic factors for a longer disease-free survival. PUBMED_ID: 14968119
We conclude that infiltration of CD8+ and CD57+ cells are important prognostic factors in colorectal cancer. PUBMED_ID: 14968119
NY-ESO-1 protein formulated in ISCOMATRIX adjuvant is a potent anticancer vaccine inducing both humoral and CD8+ t-cell-mediated immunity and protection against NY-ESO-1+ tumors. PUBMED_ID: 15102697
In humans, NY-ESO-1 is one of the most immunogenic tumor antigens and NY-ESO-1 peptides have been shown to induce NY-ESO-1-specific CD8(+) CTLs capable of altering the natural course of NY-ESO-1-expressing tumors in cancer patients. PUBMED_ID: 15102697
Furthermore, the NY-ESO-1 vaccine induced NY-ESO-1-specific CD8(+) CTLs in HLA-A2 transgenic mice that were capable of lysing human HLA-A2(+) NY-ESO-1(+) tumor cells. PUBMED_ID: 15102697
A rare population of tumor antigen-specific CD4+CD8+ double-positive alphabeta T lymphocytes uniquely provide CD8-independent TCR genes for engineering therapeutic T cells. PUBMED_ID: 30626427
RESULTS: A rare population of NY-ESO-1-specific T cells, which we named 19305DP, expressed cell surface CD4, CD8alpha, and CD8beta but not CD56 and recognized A*02+NY-ESO-1+ cancer cell lines in a CD4- and CD8-independent manner. PUBMED_ID: 30626427
Both CD4+ and CD8+ T cells that were retrovirally transduced with 19305DP-derived TCR gene (19305DP-TCR) showed strong reactivity against A*02+NY-ESO-1+ cancer cells, whereas TCR genes from the conventional A*02-restricted NY-ESO-1-specific CD8+ single-positive T-cell clones functioned only in CD8+ T cells. PUBMED_ID: 30626427
Both 19305DP-TCR gene-engineered CD4+ and CD8+ T cells eliminated A*02+NY-ESO-1+ tumor xenografts in NSG mice. PUBMED_ID: 30626427
CONCLUSION: Together, our results indicate that the naturally occurring 19305DP-TCR derived from CD4+CD8+ double-positive alphabeta T cells, is a promising therapeutic TCR gene for effective and safe adoptive T-cell therapy in A*02+ patients with NY-ESO-1-expressing tumor. PUBMED_ID: 30626427
Tumor cells expressing ligands of the activating immunoreceptor NKG2D stimulate tumor immunity mediated by natural killer (NK), gammadelta T, and CD8(+) T cells. PUBMED_ID: 14695218
The induction of potent CD8+ T cell responses by vaccines to fight microbes or tumors remains a major challenge, as many candidates for human vaccines have proved to be poorly immunogenic. PUBMED_ID: 15696196
We tested whether a synthetic ODN, CpG 7909, could improve human tumor antigen-specific CD8+ T cell responses. PUBMED_ID: 15696196
Two-Dimensional Label-Free Affinity Analysis of Tumor-Specific CD8 T Cells with a Biomimetic Plasmonic Sensor. PUBMED_ID: 30339020
******************* Regulatory Event *******************
event('NEOPLASMS',association,'HLA-A')
subject names: : ['tumor', 'neoplasia', 'cancer', 'tumors', 'tumor antigen', 'Tumor', 'cancers', 'haematological malignancies', 'neoplastic', 'necrotic tumors', 'cancer metastasis', 'malignancies', 'gynecologic cancers', 'Cancer', 'luminal-type tumors']
object names: : ['HLA', 'HLA*A2402', 'HLA-A,B,C', 'HLA-A, -B and -C.', 'HLA-A', 'HLA-A and -B', 'histocompatibility leukocyte antigen', 'leucocyte antigens (HLA)-A, -B, -DP, -DR and -G', 'HLA-A, -B, -DP and -DR', 'HLA-A,B,C and -G', 'HLA-A, -B and -G', 'HLA-A and -C', 'HLA-A, -B, -C, and -DRB1', 'HLA-A, -B, and -C']
Sentences from abstracts:
------------------------
Colorectal carcinoma cells were recognized by survivin-specific T lymphocytes, and the survivin-specific, class-I HLA-restricted T lymphocytes were fully activated and released interleukin-2 in response to HLA/survivin-peptide complexes expressed by tumor cells. PUBMED_ID: 12907624
The efficacy of tumor cell-immune cell interactions depends on a number of factors, for example, the expression of HLA-I on tumor cells, the type of immune cell, the accessibility of tumor cells for immune cells and the expression of immunogenic epitopes. PUBMED_ID: 14968119
We assessed infiltration of CD4+, CD8+, CD56+ and CD57+ cells in the tumor epithelium, tumor stroma and advancing tumor margin of 93 colorectal carcinomas and correlated this to clinicopathological parameters, the expression of HLA-A and HLA-B/C on tumor cells, the presence of a basal membrane (BM)-like structure surrounding tumor nodules and the presence of microsatellite instability/mutator phenotype (absent MLH-1 expression). PUBMED_ID: 14968119
HLA-A/BC expression by tumor cells was normal in 28/43%, heterogeneous in 59/48% and absent in 13/9% of the cases. PUBMED_ID: 14968119
However, their interaction with tumor cells is inversely correlated to the presence of HLA-I on tumor cells and a thick BM-like structure around tumor islets. PUBMED_ID: 14968119
Identification of HLA-A*0201-restricted T cell epitopes derived from the novel overexpressed tumor antigen calcium-activated chloride channel 2. PUBMED_ID: 12077286
The primed T cells also recognized allogeneic tumor cells in an Ag-specific and HLA-restricted fashion. PUBMED_ID: 12077286
******************* Regulatory Event *******************
event('Colorectal Neoplasms',association,'CD4')
subject names: : ['colorectal cancer', 'colorectal carcinoma', 'Colorectal carcinoma', 'colorectal carcinomas']
object names: : ['CD4']
Sentences from abstracts:
------------------------
The apoptosis inhibitor protein survivin induces tumor-specific CD8+ and CD4+ T cells in colorectal cancer patients. PUBMED_ID: 12907624
We assessed infiltration of CD4+, CD8+, CD56+ and CD57+ cells in the tumor epithelium, tumor stroma and advancing tumor margin of 93 colorectal carcinomas and correlated this to clinicopathological parameters, the expression of HLA-A and HLA-B/C on tumor cells, the presence of a basal membrane (BM)-like structure surrounding tumor nodules and the presence of microsatellite instability/mutator phenotype (absent MLH-1 expression). PUBMED_ID: 14968119
******************* Regulatory Event *******************
event('HLA-A',association,'IL2')
subject names: : ['HLA', 'HLA*A2402', 'HLA-A,B,C', 'HLA-A, -B and -C.', 'HLA-A', 'HLA-A and -B', 'histocompatibility leukocyte antigen', 'leucocyte antigens (HLA)-A, -B, -DP, -DR and -G', 'HLA-A, -B, -DP and -DR', 'HLA-A,B,C and -G', 'HLA-A, -B and -G', 'HLA-A and -C', 'HLA-A, -B, -C, and -DRB1', 'HLA-A, -B, and -C']
object names: : ['interleukin-2', 'IL-2', 'interleukin 2', 'interleukin (IL)-2']
Sentences from abstracts:
------------------------
Colorectal carcinoma cells were recognized by survivin-specific T lymphocytes, and the survivin-specific, class-I HLA-restricted T lymphocytes were fully activated and released interleukin-2 in response to HLA/survivin-peptide complexes expressed by tumor cells. PUBMED_ID: 12907624
******************* Regulatory Event *******************
event('NEOPLASMS',association,'CD4')
subject names: : ['tumor', 'neoplasia', 'cancer', 'tumors', 'tumor antigen', 'Tumor', 'cancers', 'haematological malignancies', 'neoplastic', 'necrotic tumors', 'cancer metastasis', 'malignancies', 'gynecologic cancers', 'Cancer', 'luminal-type tumors']
object names: : ['CD4']
Sentences from abstracts:
------------------------
The apoptosis inhibitor protein survivin induces tumor-specific CD8+ and CD4+ T cells in colorectal cancer patients. PUBMED_ID: 12907624
We assessed infiltration of CD4+, CD8+, CD56+ and CD57+ cells in the tumor epithelium, tumor stroma and advancing tumor margin of 93 colorectal carcinomas and correlated this to clinicopathological parameters, the expression of HLA-A and HLA-B/C on tumor cells, the presence of a basal membrane (BM)-like structure surrounding tumor nodules and the presence of microsatellite instability/mutator phenotype (absent MLH-1 expression). PUBMED_ID: 14968119
The median intraepithelial CD4+, CD8+, CD56+ and CD57+ cell infiltrations were 3, 23, 0 and 0 cells/mm(2) tumor, respectively. PUBMED_ID: 14968119
MHC II protein (HLA-DP, -DQ, -DR) levels and infiltration by CD4+ T-helper cells of tumor stroma increased upon NSAID treatment, while CD8+ cytotoxic T-lymphocytes increased in both tumor stroma and epithelium. PUBMED_ID: 18307280
A rare population of tumor antigen-specific CD4+CD8+ double-positive alphabeta T lymphocytes uniquely provide CD8-independent TCR genes for engineering therapeutic T cells. PUBMED_ID: 30626427
RESULTS: A rare population of NY-ESO-1-specific T cells, which we named 19305DP, expressed cell surface CD4, CD8alpha, and CD8beta but not CD56 and recognized A*02+NY-ESO-1+ cancer cell lines in a CD4- and CD8-independent manner. PUBMED_ID: 30626427
Both CD4+ and CD8+ T cells that were retrovirally transduced with 19305DP-derived TCR gene (19305DP-TCR) showed strong reactivity against A*02+NY-ESO-1+ cancer cells, whereas TCR genes from the conventional A*02-restricted NY-ESO-1-specific CD8+ single-positive T-cell clones functioned only in CD8+ T cells. PUBMED_ID: 30626427
Both 19305DP-TCR gene-engineered CD4+ and CD8+ T cells eliminated A*02+NY-ESO-1+ tumor xenografts in NSG mice. PUBMED_ID: 30626427
CONCLUSION: Together, our results indicate that the naturally occurring 19305DP-TCR derived from CD4+CD8+ double-positive alphabeta T cells, is a promising therapeutic TCR gene for effective and safe adoptive T-cell therapy in A*02+ patients with NY-ESO-1-expressing tumor. PUBMED_ID: 30626427
Depletion of CD4+ or CD8+ T cells abrogated the anti-tumor effect of pAc/emm55. PUBMED_ID: 32556443
******************* Regulatory Event *******************
event('HLA-C',positive_correlation,'IFNG')
subject names: : ['major histocompatibility complex', 'MHC', 'HLA-C and -E', 'Major Histocompatibility Complex', 'HLA-C']
object names: : ['interferon-gamma', 'IFN-gamma', 'interferon gamma', 'IFNgamma', 'Interferon-gamma', 'interferon (IFN)-gamma']
Sentences from abstracts:
------------------------
Gamma interferon (IFN-gamma) induces expression of the gene products of the major histocompatibility complex (MHC), whereas IFN-alpha/beta can interfere with or suppress class II protein expression. PUBMED_ID: 12915556
******************* Regulatory Event *******************
event('HLA-A',association,'CD8A')
subject names: : ['HLA', 'HLA*A2402', 'HLA-A,B,C', 'HLA-A, -B and -C.', 'HLA-A', 'HLA-A and -B', 'histocompatibility leukocyte antigen', 'leucocyte antigens (HLA)-A, -B, -DP, -DR and -G', 'HLA-A, -B, -DP and -DR', 'HLA-A,B,C and -G', 'HLA-A, -B and -G', 'HLA-A and -C', 'HLA-A, -B, -C, and -DRB1', 'HLA-A, -B, and -C']
object names: : ['CD8', 'CD8alpha']
Sentences from abstracts:
------------------------
Tetrameric major histocompatibility complex/peptide complex analysis demonstrated HLA*A2402-restricted phosphoprotein 65-specific CD8(+) T cells to be present in most healthy infants and adults tested, but almost absent in the patients. PUBMED_ID: 12938200
Although the majority of HIV-specific CD8(+) T cells lose proliferative capacity during chronic infection, T cells restricted by HLA-B*27 or HLA-B*57 allele groups do not. PUBMED_ID: 21765403
Here we show that CD8(+) T cells restricted by 'protective' HLA allele groups are not suppressed by T(reg) cells, whereas, within the same individual, T cells restricted by 'nonprotective' alleles are highly suppressed ex vivo. PUBMED_ID: 21765403
******************* Regulatory Event *******************
event('IFNG',association,'CD4')
subject names: : ['interferon-gamma', 'IFN-gamma', 'interferon gamma', 'IFNgamma', 'Interferon-gamma', 'interferon (IFN)-gamma']
object names: : ['CD4']
Sentences from abstracts:
------------------------
Intracellular cytokine assays showed that 0.03-2.23% of CD4(+) T cells in the healthy infants and adults produced interferon-gamma (IFN-gamma) in response to CMV antigens. PUBMED_ID: 12938200
In an 18-hour culture, HNE-loaded monocytes stimulated significant intracellular interferon gamma (IFN-gamma) production by CD4+ and CD8+ T cells in 12 of 20 and 8 of 20 healthy individuals, respectively. PUBMED_ID: 15070688
TLR agonists, especially PIC, enhanced the ability of E7-loaded mdDCs to induce IFN-gamma-secretion CD4(+) naive T cells. PUBMED_ID: 19578865
Previous studies have shown that the main population of lymphocytes present in the dermal infiltrate is CD8+ T cells, followed by CD4+ T cells, which are correlated with IFN-gamma+ cells. PUBMED_ID: 32603482
******************* Regulatory Event *******************
event('INFECTIONS',association,'PMEL')
subject names: : ['infected', 'infection', 'congenital infection', 'infections', 'Infections', 'non-tuberculous infections', 'Infection', 'ANKA infection']
object names: : ['gp100', 'PMel17']
Sentences from abstracts:
------------------------
In this study, therefore, we evaluated the efficiency of a recombinant vaccinia virus encoding the gp100/PMel17 melanoma Ag (rVV-gp100) to infect immature (iDC) or mature dendritic cells (mDC) derived from circulating mononuclear cells and the effect of infection on their status of maturation. PUBMED_ID: 12939642
In addition, we tested the ability of rVV-gp100-infected iDC and mDC to present the HLA-A*0201-associated gp100:209-217 epitope (g209). PUBMED_ID: 12939642
Irrespective of status of maturation, rVV-gp100 infection induced gp100 expression while only partially reversing the expression of some maturation markers. PUBMED_ID: 12939642
The low efficiency was epitope-specific since infection of DC with rVV encoding a gp100 construct containing the modified gp100:209-217 (210M) (g209-2M) epitope characterized by high binding affinity for HLA-A*0201 restored efficient Ag presentation. PUBMED_ID: 12939642
******************* Regulatory Event *******************
event('MELANOMA',association,'PMEL')
subject names: : ['melanoma Ag', 'melanoma', 'malignant melanoma', 'melanoma tumor', 'ciliochoroidal melanoma', 'ciliochoroidal melanomas']
object names: : ['gp100', 'PMel17']
Sentences from abstracts:
------------------------
In this study, therefore, we evaluated the efficiency of a recombinant vaccinia virus encoding the gp100/PMel17 melanoma Ag (rVV-gp100) to infect immature (iDC) or mature dendritic cells (mDC) derived from circulating mononuclear cells and the effect of infection on their status of maturation. PUBMED_ID: 12939642
The authors vaccinated 18 HLA A*0201+ patients with stage IV melanoma with CD34 HPC-derived DCs pulsed with six antigens: influenza matrix peptide (Flu-MP), KLH, and peptides derived from the four melanoma antigens: MART-1/Melan A, gp100, tyrosinase, and MAGE-3. PUBMED_ID: 12973032
******************* Regulatory Event *******************
event('HIV Infections',association,'CD8A')
subject names: : ['HIV infection', 'HIV-infected', 'HIV/AIDS', 'human immunodeficiency virus (HIV)-infected', 'HIV', 'HIV-1 infection', 'HIV or', 'HIV co-infection', 'HIV/HCV co-infection', 'HIV/HCV co-infected', 'CSF HIV', 'HIV infected', 'human immunodeficiency virus (HIV) infection', 'HIV-1-infected', 'immunodeficiency virus']
object names: : ['CD8', 'CD8alpha']
Sentences from abstracts:
------------------------
In human CMV and HIV infection, the majority of differentiated virus-specific CD8+ T cells notably lose the ability to produce IL-2 but also lose expression of CD28, a costimulatory molecule. PUBMED_ID: 12963692
Suppression of HIV Replication by CD8(+) Regulatory T-Cells in Elite Controllers. PUBMED_ID: 27148256
Here, we sought whether a similar population of CD8(+) T-regs would induce the suppression of HIV replication in elite controllers (ECs), a small population (3%) of HIV-infected patients with undetectable HIV replication. PUBMED_ID: 27148256
For that purpose, we investigated the in vitro antiviral activity of fresh CD8(+) T-cells on HIV-infected CD4(+) T-cells taken from 10 ECs. PUBMED_ID: 27148256
Our findings provide the first evidence for an instrumental role of KIR-expressing CD8(+) regulatory T-cells in the natural control of HIV-1 infection. PUBMED_ID: 27148256
Phenotype and functional characteristics of HIV-specific cytotoxic CD8+ T cells in chronically infected patients: dual effects of highly active antiretroviral therapy. PUBMED_ID: 14600569
******************* Regulatory Event *******************
event('CD8A',association,'CD28')
subject names: : ['CD8', 'CD8alpha']
object names: : ['CD28']
Sentences from abstracts:
------------------------
Restoration of CD28 expression in CD28- CD8+ memory effector T cells reconstitutes antigen-induced IL-2 production. PUBMED_ID: 12963692
In human CMV and HIV infection, the majority of differentiated virus-specific CD8+ T cells notably lose the ability to produce IL-2 but also lose expression of CD28, a costimulatory molecule. PUBMED_ID: 12963692
Analysis of the fraction of memory CD8+ T cells that continue to express CD28 revealed these cells retain the ability to produce IL-2. PUBMED_ID: 12963692
Therefore, we examined if IL-2 production by CD28- CD8+ T cells could be restored by introduction of a constitutively expressed CD28 gene. PUBMED_ID: 12963692
Expression of CD28 in CD28- CD8+ CMV- and HIV-specific CD8+ T cells reconstituted the ability to produce IL-2, which could sustain an autocrine proliferative response after Ag recognition. PUBMED_ID: 12963692
These results suggest that the loss of CD28 expression during differentiation of memory/effector CD8+ T cells represents a decisive step in establishing regulation of responding CD8+ T cells, increasing the dependence on CD4+ Th for proliferation after target recognition, and has implications for the treatment of viral disease with adoptively transferred CD8+ T cells. PUBMED_ID: 12963692
******************* Regulatory Event *******************
event('Cytomegalovirus Infections',negative_correlation,'IL2')
subject names: : ['congenital CMV infection', 'CMV-seropositive', 'CMV', 'cytomegalovirus', 'Cytomegalovirus Infection']
object names: : ['interleukin-2', 'IL-2', 'interleukin 2', 'interleukin (IL)-2']
Sentences from abstracts:
------------------------
In human CMV and HIV infection, the majority of differentiated virus-specific CD8+ T cells notably lose the ability to produce IL-2 but also lose expression of CD28, a costimulatory molecule. PUBMED_ID: 12963692
Expression of CD28 in CD28- CD8+ CMV- and HIV-specific CD8+ T cells reconstituted the ability to produce IL-2, which could sustain an autocrine proliferative response after Ag recognition. PUBMED_ID: 12963692
******************* Regulatory Event *******************
event('Virus Diseases',association,'CD8A')
subject names: : ['viral infections', 'viral disease', 'viral infection', 'viral co-infections', 'viral', 'virus']
object names: : ['CD8', 'CD8alpha']
Sentences from abstracts:
------------------------
The control of many persistent viral infections by Ag-specific cytolytic CD8+ T cells requires a concurrent virus-specific CD4+ Th cell response. PUBMED_ID: 12963692
These results suggest that the loss of CD28 expression during differentiation of memory/effector CD8+ T cells represents a decisive step in establishing regulation of responding CD8+ T cells, increasing the dependence on CD4+ Th for proliferation after target recognition, and has implications for the treatment of viral disease with adoptively transferred CD8+ T cells. PUBMED_ID: 12963692
BACKGROUND: Cytotoxic CD8+ T cells (CTLs) are critical for the control of viral infections. PUBMED_ID: 14600569
******************* Regulatory Event *******************
event('IL2',association,'CD28')
subject names: : ['interleukin-2', 'IL-2', 'interleukin 2', 'interleukin (IL)-2']
object names: : ['CD28']
Sentences from abstracts:
------------------------
Restoration of CD28 expression in CD28- CD8+ memory effector T cells reconstitutes antigen-induced IL-2 production. PUBMED_ID: 12963692
In human CMV and HIV infection, the majority of differentiated virus-specific CD8+ T cells notably lose the ability to produce IL-2 but also lose expression of CD28, a costimulatory molecule. PUBMED_ID: 12963692
Analysis of the fraction of memory CD8+ T cells that continue to express CD28 revealed these cells retain the ability to produce IL-2. PUBMED_ID: 12963692
Therefore, we examined if IL-2 production by CD28- CD8+ T cells could be restored by introduction of a constitutively expressed CD28 gene. PUBMED_ID: 12963692
Expression of CD28 in CD28- CD8+ CMV- and HIV-specific CD8+ T cells reconstituted the ability to produce IL-2, which could sustain an autocrine proliferative response after Ag recognition. PUBMED_ID: 12963692
******************* Regulatory Event *******************
event('HIV Infections',association,'CD28')
subject names: : ['HIV infection', 'HIV-infected', 'HIV/AIDS', 'human immunodeficiency virus (HIV)-infected', 'HIV', 'HIV-1 infection', 'HIV or', 'HIV co-infection', 'HIV/HCV co-infection', 'HIV/HCV co-infected', 'CSF HIV', 'HIV infected', 'human immunodeficiency virus (HIV) infection', 'HIV-1-infected', 'immunodeficiency virus']
object names: : ['CD28']
Sentences from abstracts:
------------------------
In human CMV and HIV infection, the majority of differentiated virus-specific CD8+ T cells notably lose the ability to produce IL-2 but also lose expression of CD28, a costimulatory molecule. PUBMED_ID: 12963692
******************* Regulatory Event *******************
event('HIV Infections',association,'IL2')
subject names: : ['HIV infection', 'HIV-infected', 'HIV/AIDS', 'human immunodeficiency virus (HIV)-infected', 'HIV', 'HIV-1 infection', 'HIV or', 'HIV co-infection', 'HIV/HCV co-infection', 'HIV/HCV co-infected', 'CSF HIV', 'HIV infected', 'human immunodeficiency virus (HIV) infection', 'HIV-1-infected', 'immunodeficiency virus']
object names: : ['interleukin-2', 'IL-2', 'interleukin 2', 'interleukin (IL)-2']
Sentences from abstracts:
------------------------
In human CMV and HIV infection, the majority of differentiated virus-specific CD8+ T cells notably lose the ability to produce IL-2 but also lose expression of CD28, a costimulatory molecule. PUBMED_ID: 12963692
******************* Regulatory Event *******************
event('Virus Diseases',association,'CD4')
subject names: : ['viral infections', 'viral disease', 'viral infection', 'viral co-infections', 'viral', 'virus']
object names: : ['CD4']
Sentences from abstracts:
------------------------
The control of many persistent viral infections by Ag-specific cytolytic CD8+ T cells requires a concurrent virus-specific CD4+ Th cell response. PUBMED_ID: 12963692
These results suggest that the loss of CD28 expression during differentiation of memory/effector CD8+ T cells represents a decisive step in establishing regulation of responding CD8+ T cells, increasing the dependence on CD4+ Th for proliferation after target recognition, and has implications for the treatment of viral disease with adoptively transferred CD8+ T cells. PUBMED_ID: 12963692
******************* Regulatory Event *******************
event('Cytomegalovirus Infections',association,'CD28')
subject names: : ['congenital CMV infection', 'CMV-seropositive', 'CMV', 'cytomegalovirus', 'Cytomegalovirus Infection']
object names: : ['CD28']
Sentences from abstracts:
------------------------
In human CMV and HIV infection, the majority of differentiated virus-specific CD8+ T cells notably lose the ability to produce IL-2 but also lose expression of CD28, a costimulatory molecule. PUBMED_ID: 12963692
Expression of CD28 in CD28- CD8+ CMV- and HIV-specific CD8+ T cells reconstituted the ability to produce IL-2, which could sustain an autocrine proliferative response after Ag recognition. PUBMED_ID: 12963692
******************* Regulatory Event *******************
event('IL2',association,'CD8A')
subject names: : ['interleukin-2', 'IL-2', 'interleukin 2', 'interleukin (IL)-2']
object names: : ['CD8', 'CD8alpha']
Sentences from abstracts:
------------------------
Restoration of CD28 expression in CD28- CD8+ memory effector T cells reconstitutes antigen-induced IL-2 production. PUBMED_ID: 12963692
This reflects in part a requirement of activated effector CD8+ T cells for paracrine IL-2 production as a growth and survival factor. PUBMED_ID: 12963692
In human CMV and HIV infection, the majority of differentiated virus-specific CD8+ T cells notably lose the ability to produce IL-2 but also lose expression of CD28, a costimulatory molecule. PUBMED_ID: 12963692
Analysis of the fraction of memory CD8+ T cells that continue to express CD28 revealed these cells retain the ability to produce IL-2. PUBMED_ID: 12963692
Therefore, we examined if IL-2 production by CD28- CD8+ T cells could be restored by introduction of a constitutively expressed CD28 gene. PUBMED_ID: 12963692
Expression of CD28 in CD28- CD8+ CMV- and HIV-specific CD8+ T cells reconstituted the ability to produce IL-2, which could sustain an autocrine proliferative response after Ag recognition. PUBMED_ID: 12963692
******************* Regulatory Event *******************
event('MELANOMA',association,'TYR')
subject names: : ['melanoma Ag', 'melanoma', 'malignant melanoma', 'melanoma tumor', 'ciliochoroidal melanoma', 'ciliochoroidal melanomas']
object names: : ['tyrosinase']
Sentences from abstracts:
------------------------
The authors vaccinated 18 HLA A*0201+ patients with stage IV melanoma with CD34 HPC-derived DCs pulsed with six antigens: influenza matrix peptide (Flu-MP), KLH, and peptides derived from the four melanoma antigens: MART-1/Melan A, gp100, tyrosinase, and MAGE-3. PUBMED_ID: 12973032
The human tyrosinase (hTyr) (369-377) cytotoxic T lymphocyte (CTL) epitope is presented by malignant melanoma and various nontransformed cells in association with human leukocyte antigen (HLA)-A*0201 (A2.1) and used for vaccination-based immunotherapy of melanoma patients. PUBMED_ID: 14696122
******************* Regulatory Event *******************
event('MELANOMA',association,'MLANA')
subject names: : ['melanoma Ag', 'melanoma', 'malignant melanoma', 'melanoma tumor', 'ciliochoroidal melanoma', 'ciliochoroidal melanomas']
object names: : ['MART-1', 'Melan A', 'MART1', 'Melan-A', 'melanoma antigen A']
Sentences from abstracts:
------------------------
The authors vaccinated 18 HLA A*0201+ patients with stage IV melanoma with CD34 HPC-derived DCs pulsed with six antigens: influenza matrix peptide (Flu-MP), KLH, and peptides derived from the four melanoma antigens: MART-1/Melan A, gp100, tyrosinase, and MAGE-3. PUBMED_ID: 12973032
We investigated the immunogenic nature of GFP in humans and further explored whether this xenoprotein could be used as a functional adjuvant to enhance T-cell immunity to the melanoma tumor antigen MART1. PUBMED_ID: 15102483
Eight HLA-A2+ melanoma patients received 4 monthly vaccinations of low-dose CpG 7909 mixed with melanoma antigen A (Melan-A; identical to MART-1) analog peptide and incomplete Freund's adjuvant. PUBMED_ID: 15696196
******************* Regulatory Event *******************
event('MELANOMA',association,'CD34')
subject names: : ['melanoma Ag', 'melanoma', 'malignant melanoma', 'melanoma tumor', 'ciliochoroidal melanoma', 'ciliochoroidal melanomas']
object names: : ['CD34']
Sentences from abstracts:
------------------------
Single injection of CD34+ progenitor-derived dendritic cell vaccine can lead to induction of T-cell immunity in patients with stage IV melanoma. PUBMED_ID: 12973032
The authors vaccinated 18 HLA A*0201+ patients with stage IV melanoma with CD34 HPC-derived DCs pulsed with six antigens: influenza matrix peptide (Flu-MP), KLH, and peptides derived from the four melanoma antigens: MART-1/Melan A, gp100, tyrosinase, and MAGE-3. PUBMED_ID: 12973032
Thus, a single injection of CD34 HPC-derived DCs can lead to rapid immune response to CD4 epitopes or to melanoma antigens. PUBMED_ID: 12973032
******************* Regulatory Event *******************
event('MELANOMA',association,'MAGEA3')
subject names: : ['melanoma Ag', 'melanoma', 'malignant melanoma', 'melanoma tumor', 'ciliochoroidal melanoma', 'ciliochoroidal melanomas']
object names: : ['MAGE-3']
Sentences from abstracts:
------------------------
The authors vaccinated 18 HLA A*0201+ patients with stage IV melanoma with CD34 HPC-derived DCs pulsed with six antigens: influenza matrix peptide (Flu-MP), KLH, and peptides derived from the four melanoma antigens: MART-1/Melan A, gp100, tyrosinase, and MAGE-3. PUBMED_ID: 12973032
******************* Regulatory Event *******************
event('NEOPLASMS',association,'MLANA')
subject names: : ['tumor', 'neoplasia', 'cancer', 'tumors', 'tumor antigen', 'Tumor', 'cancers', 'haematological malignancies', 'neoplastic', 'necrotic tumors', 'cancer metastasis', 'malignancies', 'gynecologic cancers', 'Cancer', 'luminal-type tumors']
object names: : ['MART-1', 'Melan A', 'MART1', 'Melan-A', 'melanoma antigen A']
Sentences from abstracts:
------------------------
In the presence of antigen-presenting cells (APC), exosomes directly loaded with the HLA-A2 restricted MART1 tumor peptide stimulated an HLA-A2/MART1 specific T-cell line. PUBMED_ID: 12973033
The results show that wild type Ii, and Ii in which CLIP was replaced by known CTL epitopes from the cancer targets MART-1 or CD20, coprecipitated with HLA-A*02:01 and mediated colocalization in the endosomal pathway. PUBMED_ID: 24293164
******************* Regulatory Event *******************
event('Autistic Disorder',association,'WDR11')
subject names: : ['autistic', 'autism']
object names: : ['DR11']
Sentences from abstracts:
------------------------
Significant association of HLA A2-DR11 with CD4 naive decrease in autistic children. PUBMED_ID: 14568232
These differences were significantly more pronounced in the autistic children bearing the HLA A2 and DR11 alleles. PUBMED_ID: 14568232
******************* Regulatory Event *******************
event('Autistic Disorder',association,'CD4')
subject names: : ['autistic', 'autism']
object names: : ['CD4']
Sentences from abstracts:
------------------------
Significant association of HLA A2-DR11 with CD4 naive decrease in autistic children. PUBMED_ID: 14568232
We observed a significant decrease in CD4+ naive and an increase in CD4+ memory T cells in autistic children. PUBMED_ID: 14568232
******************* Regulatory Event *******************
event('WDR11',association,'CD4')
subject names: : ['DR11']
object names: : ['CD4']
Sentences from abstracts:
------------------------
Significant association of HLA A2-DR11 with CD4 naive decrease in autistic children. PUBMED_ID: 14568232
******************* Regulatory Event *******************
event('ICAM1',positive_correlation,'IFNG')
subject names: : ['ICAM-1']
object names: : ['interferon-gamma', 'IFN-gamma', 'interferon gamma', 'IFNgamma', 'Interferon-gamma', 'interferon (IFN)-gamma']
Sentences from abstracts:
------------------------
It is likely that the follicular expression of HLA-DR and ICAM-1 is induced by interferon-gamma produced by T cells. PUBMED_ID: 14582666
******************* Regulatory Event *******************
event('ALOPECIA',association,'CD8A')
subject names: : ['Hair loss', 'hair loss']
object names: : ['CD8', 'CD8alpha']
Sentences from abstracts:
------------------------
Hair loss is associated with a perifollicular lymphocytic infiltrate made up primarily of CD4+ cells, along with a CD8+ intrafollicular infiltrate. PUBMED_ID: 14582666
******************* Regulatory Event *******************
event('CTAG1A',association,'CD4')
subject names: : ['NY-ESO-1']
object names: : ['CD4']
Sentences from abstracts:
------------------------
NY-ESO-1-specific immune responses were observed for CD4(+) and CD8(+) T cells from peripheral blood lymphocytes in 4 of 8 neuroblastoma patients, as detected by IFN-gamma enzyme-linked immunospot assay after in vitro stimulation either with the NY-ESO-1 recombinant protein or with the HLA-A2-restricted peptide NY-ESO-1(157-167). PUBMED_ID: 14583496
NY-ESO-1-specific CD4(+) and CD8(+) T cells were also able to recognize NY-ESO-1 expressing neuroblastoma cells. PUBMED_ID: 14583496
In addition, epitopes of NY-ESO-1 protein were also presented on MHC class II molecules to NY-ESO-1-specific CD4(+) T cells. PUBMED_ID: 15102697
RESULTS: A rare population of NY-ESO-1-specific T cells, which we named 19305DP, expressed cell surface CD4, CD8alpha, and CD8beta but not CD56 and recognized A*02+NY-ESO-1+ cancer cell lines in a CD4- and CD8-independent manner. PUBMED_ID: 30626427
Both CD4+ and CD8+ T cells that were retrovirally transduced with 19305DP-derived TCR gene (19305DP-TCR) showed strong reactivity against A*02+NY-ESO-1+ cancer cells, whereas TCR genes from the conventional A*02-restricted NY-ESO-1-specific CD8+ single-positive T-cell clones functioned only in CD8+ T cells. PUBMED_ID: 30626427
Both 19305DP-TCR gene-engineered CD4+ and CD8+ T cells eliminated A*02+NY-ESO-1+ tumor xenografts in NSG mice. PUBMED_ID: 30626427
CONCLUSION: Together, our results indicate that the naturally occurring 19305DP-TCR derived from CD4+CD8+ double-positive alphabeta T cells, is a promising therapeutic TCR gene for effective and safe adoptive T-cell therapy in A*02+ patients with NY-ESO-1-expressing tumor. PUBMED_ID: 30626427
******************* Regulatory Event *******************
event('NEUROBLASTOMA',association,'CD4')
subject names: : ['neuroblastoma', 'Neuroblastoma']
object names: : ['CD4']
Sentences from abstracts:
------------------------
NY-ESO-1-specific immune responses were observed for CD4(+) and CD8(+) T cells from peripheral blood lymphocytes in 4 of 8 neuroblastoma patients, as detected by IFN-gamma enzyme-linked immunospot assay after in vitro stimulation either with the NY-ESO-1 recombinant protein or with the HLA-A2-restricted peptide NY-ESO-1(157-167). PUBMED_ID: 14583496
NY-ESO-1-specific CD4(+) and CD8(+) T cells were also able to recognize NY-ESO-1 expressing neuroblastoma cells. PUBMED_ID: 14583496
******************* Regulatory Event *******************
event('CTAG1A',association,'CD8A')
subject names: : ['NY-ESO-1']
object names: : ['CD8', 'CD8alpha']
Sentences from abstracts:
------------------------
NY-ESO-1-specific immune responses were observed for CD4(+) and CD8(+) T cells from peripheral blood lymphocytes in 4 of 8 neuroblastoma patients, as detected by IFN-gamma enzyme-linked immunospot assay after in vitro stimulation either with the NY-ESO-1 recombinant protein or with the HLA-A2-restricted peptide NY-ESO-1(157-167). PUBMED_ID: 14583496
NY-ESO-1-specific CD4(+) and CD8(+) T cells were also able to recognize NY-ESO-1 expressing neuroblastoma cells. PUBMED_ID: 14583496
NY-ESO-1 protein formulated in ISCOMATRIX adjuvant is a potent anticancer vaccine inducing both humoral and CD8+ t-cell-mediated immunity and protection against NY-ESO-1+ tumors. PUBMED_ID: 15102697
In humans, NY-ESO-1 is one of the most immunogenic tumor antigens and NY-ESO-1 peptides have been shown to induce NY-ESO-1-specific CD8(+) CTLs capable of altering the natural course of NY-ESO-1-expressing tumors in cancer patients. PUBMED_ID: 15102697
In vitro, the NY-ESO-1 vaccine was readily taken up by human monocyte-derived dendritic cells, and on maturation, these human monocyte-derived dendritic cells efficiently cross-presented HLA-A2-restricted epitopes to NY-ESO-1-specific CD8(+) T cells. PUBMED_ID: 15102697
Furthermore, the NY-ESO-1 vaccine induced NY-ESO-1-specific CD8(+) CTLs in HLA-A2 transgenic mice that were capable of lysing human HLA-A2(+) NY-ESO-1(+) tumor cells. PUBMED_ID: 15102697
RESULTS: A rare population of NY-ESO-1-specific T cells, which we named 19305DP, expressed cell surface CD4, CD8alpha, and CD8beta but not CD56 and recognized A*02+NY-ESO-1+ cancer cell lines in a CD4- and CD8-independent manner. PUBMED_ID: 30626427
Both CD4+ and CD8+ T cells that were retrovirally transduced with 19305DP-derived TCR gene (19305DP-TCR) showed strong reactivity against A*02+NY-ESO-1+ cancer cells, whereas TCR genes from the conventional A*02-restricted NY-ESO-1-specific CD8+ single-positive T-cell clones functioned only in CD8+ T cells. PUBMED_ID: 30626427
Both 19305DP-TCR gene-engineered CD4+ and CD8+ T cells eliminated A*02+NY-ESO-1+ tumor xenografts in NSG mice. PUBMED_ID: 30626427
CONCLUSION: Together, our results indicate that the naturally occurring 19305DP-TCR derived from CD4+CD8+ double-positive alphabeta T cells, is a promising therapeutic TCR gene for effective and safe adoptive T-cell therapy in A*02+ patients with NY-ESO-1-expressing tumor. PUBMED_ID: 30626427
******************* Regulatory Event *******************
event('NEUROBLASTOMA',association,'CD8A')
subject names: : ['neuroblastoma', 'Neuroblastoma']
object names: : ['CD8', 'CD8alpha']
Sentences from abstracts:
------------------------
NY-ESO-1-specific immune responses were observed for CD4(+) and CD8(+) T cells from peripheral blood lymphocytes in 4 of 8 neuroblastoma patients, as detected by IFN-gamma enzyme-linked immunospot assay after in vitro stimulation either with the NY-ESO-1 recombinant protein or with the HLA-A2-restricted peptide NY-ESO-1(157-167). PUBMED_ID: 14583496
NY-ESO-1-specific CD4(+) and CD8(+) T cells were also able to recognize NY-ESO-1 expressing neuroblastoma cells. PUBMED_ID: 14583496
******************* Regulatory Event *******************
event('NEUROBLASTOMA',association,'CTAG1A')
subject names: : ['neuroblastoma', 'Neuroblastoma']
object names: : ['NY-ESO-1']
Sentences from abstracts:
------------------------
Antigen-specific immunity in neuroblastoma patients: antibody and T-cell recognition of NY-ESO-1 tumor antigen. PUBMED_ID: 14583496
In the present work we addressed the issue of whether NY-ESO-1, a germ cell antigen aberrantly expressed in different tumor types, is expressed by neuroblastoma cells and may represent a target for humoral and/or cellular immune responses in neuroblastoma patients. PUBMED_ID: 14583496
We found that a large fraction of neuroblastoma biopsies, independently from the clinical stage and degree of tumor cell differentiation, expressed significant levels of NY-ESO-1 as assessed by reverse transcription-PCR and immunohistochemistry. PUBMED_ID: 14583496
NY-ESO-1-specific IgG antibodies were detected in the sera of 10% of neuroblastoma patients with stage III or IV disease, but not in patients in clinical remission or with earlier stages. PUBMED_ID: 14583496
NY-ESO-1-specific immune responses were observed for CD4(+) and CD8(+) T cells from peripheral blood lymphocytes in 4 of 8 neuroblastoma patients, as detected by IFN-gamma enzyme-linked immunospot assay after in vitro stimulation either with the NY-ESO-1 recombinant protein or with the HLA-A2-restricted peptide NY-ESO-1(157-167). PUBMED_ID: 14583496
NY-ESO-1-specific CD4(+) and CD8(+) T cells were also able to recognize NY-ESO-1 expressing neuroblastoma cells. PUBMED_ID: 14583496
We conclude that NY-ESO-1 is an immunogenic antigen in neuroblastoma patients and represents a candidate target for immune-based therapy. PUBMED_ID: 14583496
******************* Regulatory Event *******************
event('MYO1G',association,'CD8A')
subject names: : ['HA-2']
object names: : ['CD8', 'CD8alpha']
Sentences from abstracts:
------------------------
Minor H antigens HY-, HA-1-, and HA-2-specific cytotoxic T cells (CD8+, CD45RA-) were present in PBMCs from 4 of 7 female donors up to 22 years after the last delivery. PUBMED_ID: 14592836
******************* Regulatory Event *******************
event('Granulomatosis with Polyangiitis',association,'CD4')
subject names: : ["Wegener's granulomatosis", "Wegener's granulomatois", 'WG']
object names: : ['CD4']
Sentences from abstracts:
------------------------
RESULTS: Frequencies of PR3-specific peripheral blood T cells after short-term stimulation (<or=0.4%) were lower compared to frequencies of PR3-specific CD4(+)T cells (0.64+/-0.09%, mean+/-SEM) and PR3-specific CD8(+)T cells (0.65+/-0.18%) after 10 days of stimulation in WG. PUBMED_ID: 14709416
******************* Regulatory Event *******************
event('Granulomatosis with Polyangiitis',association,'TNF')
subject names: : ["Wegener's granulomatosis", "Wegener's granulomatois", 'WG']
object names: : ['TNF-alpha', 'tumor necrosis factor alpha', 'TNFalpha', 'tumor necrosis factor-alpha', 'TNF', 'tumor necrosis factor (TNF)-alpha']
Sentences from abstracts:
------------------------
CONCLUSION: Low frequencies of TNF-alpha(+)PR3-specific T cells can be detected in individual WG patients and controls using cytokine flow cytometry. PUBMED_ID: 14709416
******************* Regulatory Event *******************
event('Granulomatosis with Polyangiitis',association,'CD8A')
subject names: : ["Wegener's granulomatosis", "Wegener's granulomatois", 'WG']
object names: : ['CD8', 'CD8alpha']
Sentences from abstracts:
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RESULTS: Frequencies of PR3-specific peripheral blood T cells after short-term stimulation (<or=0.4%) were lower compared to frequencies of PR3-specific CD4(+)T cells (0.64+/-0.09%, mean+/-SEM) and PR3-specific CD8(+)T cells (0.65+/-0.18%) after 10 days of stimulation in WG. PUBMED_ID: 14709416
The frequency of PR3-specific CD8(+)T cells stimulated with a preferentially HLA-A*0201 binding PR3-peptide sequence was higher compared to the frequency of T cells stimulated with a HLA-B*0702 binding PR3-peptide in one WG patient whose HLA type was known (A2B7). PUBMED_ID: 14709416
******************* Regulatory Event *******************
event('Granulomatosis with Polyangiitis',association,'PRTN3')
subject names: : ["Wegener's granulomatosis", "Wegener's granulomatois", 'WG']
object names: : ['proteinase 3', 'PRO3']
Sentences from abstracts:
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Frequency of proteinase 3 (PR3)-specific autoreactive T cells determined by cytokine flow cytometry in Wegener's granulomatosis. PUBMED_ID: 14709416
******************* Regulatory Event *******************
event('HLA-A',association,'UBE2V1')
subject names: : ['HLA', 'HLA*A2402', 'HLA-A,B,C', 'HLA-A, -B and -C.', 'HLA-A', 'HLA-A and -B', 'histocompatibility leukocyte antigen', 'leucocyte antigens (HLA)-A, -B, -DP, -DR and -G', 'HLA-A, -B, -DP and -DR', 'HLA-A,B,C and -G', 'HLA-A, -B and -G', 'HLA-A and -C', 'HLA-A, -B, -C, and -DRB1', 'HLA-A, -B, and -C']
object names: : ['UBE2V']
Sentences from abstracts:
------------------------
In this study we tried to elucidate the mechanisms by which vaccination of class I binding tumor peptides into an HLA-A2(+) lung cancer patient elicited dramatic amounts of IgG1 and IgG2 specific to a nonamer peptide, ubiquitin-conjugated enzyme variant Kua (UBE2V)(43-51). PUBMED_ID: 14764741
HLA-DR-restricted and UBE2V(43-51) peptide-recognizing CD4(+) T cells were induced from postvaccination, but not from prevaccination, PBMCs of the cancer patient. PUBMED_ID: 14764741
In addition, a CD4(+) T cell line (UB-2) and its clone (UB-2.3), both of which recognize the UBE2V(43-51) peptide in the context of HLA-DRB1*0403 molecules, were successfully established from postvaccination PBMCs. PUBMED_ID: 14764741
******************* Regulatory Event *******************
event('NEOPLASMS',association,'UBE2V1')
subject names: : ['tumor', 'neoplasia', 'cancer', 'tumors', 'tumor antigen', 'Tumor', 'cancers', 'haematological malignancies', 'neoplastic', 'necrotic tumors', 'cancer metastasis', 'malignancies', 'gynecologic cancers', 'Cancer', 'luminal-type tumors']
object names: : ['UBE2V']
Sentences from abstracts:
------------------------
In this study we tried to elucidate the mechanisms by which vaccination of class I binding tumor peptides into an HLA-A2(+) lung cancer patient elicited dramatic amounts of IgG1 and IgG2 specific to a nonamer peptide, ubiquitin-conjugated enzyme variant Kua (UBE2V)(43-51). PUBMED_ID: 14764741
HLA-DR-restricted and UBE2V(43-51) peptide-recognizing CD4(+) T cells were induced from postvaccination, but not from prevaccination, PBMCs of the cancer patient. PUBMED_ID: 14764741
******************* Regulatory Event *******************
event('HLA-DRB1',association,'UBE2V1')
subject names: : ['HLA-DRB1', 'HLA DRB1', 'DRB1']
object names: : ['UBE2V']
Sentences from abstracts:
------------------------
In addition, a CD4(+) T cell line (UB-2) and its clone (UB-2.3), both of which recognize the UBE2V(43-51) peptide in the context of HLA-DRB1*0403 molecules, were successfully established from postvaccination PBMCs. PUBMED_ID: 14764741
******************* Regulatory Event *******************
event('UBE2V1',association,'CD4')
subject names: : ['UBE2V']
object names: : ['CD4']
Sentences from abstracts:
------------------------
HLA-DR-restricted and UBE2V(43-51) peptide-recognizing CD4(+) T cells were induced from postvaccination, but not from prevaccination, PBMCs of the cancer patient. PUBMED_ID: 14764741
In addition, a CD4(+) T cell line (UB-2) and its clone (UB-2.3), both of which recognize the UBE2V(43-51) peptide in the context of HLA-DRB1*0403 molecules, were successfully established from postvaccination PBMCs. PUBMED_ID: 14764741
******************* Regulatory Event *******************
event('Lung Neoplasms',association,'TMEM189')
subject names: : ['lung cancer', 'Lung cancer']
object names: : ['Kua']
Sentences from abstracts:
------------------------
In this study we tried to elucidate the mechanisms by which vaccination of class I binding tumor peptides into an HLA-A2(+) lung cancer patient elicited dramatic amounts of IgG1 and IgG2 specific to a nonamer peptide, ubiquitin-conjugated enzyme variant Kua (UBE2V)(43-51). PUBMED_ID: 14764741
******************* Regulatory Event *******************
event('Lung Neoplasms',association,'UBE2V1')
subject names: : ['lung cancer', 'Lung cancer']
object names: : ['UBE2V']
Sentences from abstracts:
------------------------
In this study we tried to elucidate the mechanisms by which vaccination of class I binding tumor peptides into an HLA-A2(+) lung cancer patient elicited dramatic amounts of IgG1 and IgG2 specific to a nonamer peptide, ubiquitin-conjugated enzyme variant Kua (UBE2V)(43-51). PUBMED_ID: 14764741
******************* Regulatory Event *******************
event('Colorectal Neoplasms',association,'HLA-C')
subject names: : ['colorectal cancer', 'colorectal carcinoma', 'Colorectal carcinoma', 'colorectal carcinomas']
object names: : ['major histocompatibility complex', 'MHC', 'HLA-C and -E', 'Major Histocompatibility Complex', 'HLA-C']
Sentences from abstracts:
------------------------
Immune system and prognosis in colorectal cancer: a detailed immunohistochemical analysis. The efficacy of tumor cell-immune cell interactions depends on a number of factors, for example, the expression of HLA-I on tumor cells, the type of immune cell, the accessibility of tumor cells for immune cells and the expression of immunogenic epitopes. We assessed infiltration of CD4+, CD8+, CD56+ and CD57+ cells in the tumor epithelium, tumor stroma and advancing tumor margin of 93 colorectal carcinomas and correlated this to clinicopathological parameters, the expression of HLA-A and HLA-B/C on tumor cells, the presence of a basal membrane (BM)-like structure surrounding tumor nodules and the presence of microsatellite instability/mutator phenotype (absent MLH-1 expression). The median intraepithelial CD4+, CD8+, CD56+ and CD57+ cell infiltrations were 3, 23, 0 and 0 cells/mm(2) tumor, respectively. HLA-A/BC expression by tumor cells was normal in 28/43%, heterogeneous in 59/48% and absent in 13/9% of the cases. A BM-like structure surrounding the tumor nodules was absent, present and thick in 47, 38 and 15% of the cases. Six cases lost MLH1 expression. There was a positive correlation between leukocyte infiltration in the three compartments for CD4+, CD8+, CD56+ (partly) and CD57+ (all P<0.05) cell infiltration. Intraepithelial CD8+ cell infiltration inversely correlated with HLA-A (P=0.04) and HLA-B/C expression (P=0.04). Intraepithelial CD57+ cell infiltration inversely correlated with HLA-B/C expression (P=0.04). Moreover, intraepithelial infiltration of CD8+ and CD57+ cells was inversely correlated to the presence of a BM-like structure (P=0.003 and 0.04, respectively). Uni- and multivariate analyses showed that a lower tumor stage (P=0.004) and marked infiltration of CD8+ (P=0.04) and CD57+ cells (P=0.05) at the advancing tumor margin were independent prognostic factors for a longer disease-free survival. Loss of MLH1 expression was correlated with a significantly higher intraepithelial CD8+ and CD57+ cell infiltration. We conclude that infiltration of CD8+ and CD57+ cells are important prognostic factors in colorectal cancer. However, their interaction with tumor cells is inversely correlated to the presence of HLA-I on tumor cells and a thick BM-like structure around tumor islets. Our data indicate that NK cells might play an important role in the immune surveillance in colorectal cancer patients. PUBMED_ID: 14968119
******************* Regulatory Event *******************
event('Colorectal Neoplasms',association,'NCAM1')
subject names: : ['colorectal cancer', 'colorectal carcinoma', 'Colorectal carcinoma', 'colorectal carcinomas']
object names: : ['CD56']
Sentences from abstracts:
------------------------
We assessed infiltration of CD4+, CD8+, CD56+ and CD57+ cells in the tumor epithelium, tumor stroma and advancing tumor margin of 93 colorectal carcinomas and correlated this to clinicopathological parameters, the expression of HLA-A and HLA-B/C on tumor cells, the presence of a basal membrane (BM)-like structure surrounding tumor nodules and the presence of microsatellite instability/mutator phenotype (absent MLH-1 expression). PUBMED_ID: 14968119
******************* Regulatory Event *******************
event('NEOPLASMS',association,'NCAM1')
subject names: : ['tumor', 'neoplasia', 'cancer', 'tumors', 'tumor antigen', 'Tumor', 'cancers', 'haematological malignancies', 'neoplastic', 'necrotic tumors', 'cancer metastasis', 'malignancies', 'gynecologic cancers', 'Cancer', 'luminal-type tumors']
object names: : ['CD56']
Sentences from abstracts:
------------------------
We assessed infiltration of CD4+, CD8+, CD56+ and CD57+ cells in the tumor epithelium, tumor stroma and advancing tumor margin of 93 colorectal carcinomas and correlated this to clinicopathological parameters, the expression of HLA-A and HLA-B/C on tumor cells, the presence of a basal membrane (BM)-like structure surrounding tumor nodules and the presence of microsatellite instability/mutator phenotype (absent MLH-1 expression). PUBMED_ID: 14968119
The median intraepithelial CD4+, CD8+, CD56+ and CD57+ cell infiltrations were 3, 23, 0 and 0 cells/mm(2) tumor, respectively. PUBMED_ID: 14968119
******************* Regulatory Event *******************
event('Colorectal Neoplasms',association,'HLA-B')
subject names: : ['colorectal cancer', 'colorectal carcinoma', 'Colorectal carcinoma', 'colorectal carcinomas']
object names: : ['HLA-B/C', 'HLA-B', 'HLA-B27', 'HLA-B*27']
Sentences from abstracts:
------------------------
We assessed infiltration of CD4+, CD8+, CD56+ and CD57+ cells in the tumor epithelium, tumor stroma and advancing tumor margin of 93 colorectal carcinomas and correlated this to clinicopathological parameters, the expression of HLA-A and HLA-B/C on tumor cells, the presence of a basal membrane (BM)-like structure surrounding tumor nodules and the presence of microsatellite instability/mutator phenotype (absent MLH-1 expression). PUBMED_ID: 14968119
******************* Regulatory Event *******************
event('Colorectal Neoplasms',association,'B3GAT1')
subject names: : ['colorectal cancer', 'colorectal carcinoma', 'Colorectal carcinoma', 'colorectal carcinomas']
object names: : ['CD57']
Sentences from abstracts:
------------------------
We assessed infiltration of CD4+, CD8+, CD56+ and CD57+ cells in the tumor epithelium, tumor stroma and advancing tumor margin of 93 colorectal carcinomas and correlated this to clinicopathological parameters, the expression of HLA-A and HLA-B/C on tumor cells, the presence of a basal membrane (BM)-like structure surrounding tumor nodules and the presence of microsatellite instability/mutator phenotype (absent MLH-1 expression). PUBMED_ID: 14968119
We conclude that infiltration of CD8+ and CD57+ cells are important prognostic factors in colorectal cancer. PUBMED_ID: 14968119
******************* Regulatory Event *******************
event('NEOPLASMS',association,'B3GAT1')
subject names: : ['tumor', 'neoplasia', 'cancer', 'tumors', 'tumor antigen', 'Tumor', 'cancers', 'haematological malignancies', 'neoplastic', 'necrotic tumors', 'cancer metastasis', 'malignancies', 'gynecologic cancers', 'Cancer', 'luminal-type tumors']
object names: : ['CD57']
Sentences from abstracts:
------------------------
We assessed infiltration of CD4+, CD8+, CD56+ and CD57+ cells in the tumor epithelium, tumor stroma and advancing tumor margin of 93 colorectal carcinomas and correlated this to clinicopathological parameters, the expression of HLA-A and HLA-B/C on tumor cells, the presence of a basal membrane (BM)-like structure surrounding tumor nodules and the presence of microsatellite instability/mutator phenotype (absent MLH-1 expression). PUBMED_ID: 14968119
The median intraepithelial CD4+, CD8+, CD56+ and CD57+ cell infiltrations were 3, 23, 0 and 0 cells/mm(2) tumor, respectively. PUBMED_ID: 14968119
Uni- and multivariate analyses showed that a lower tumor stage (P=0.004) and marked infiltration of CD8+ (P=0.04) and CD57+ cells (P=0.05) at the advancing tumor margin were independent prognostic factors for a longer disease-free survival. PUBMED_ID: 14968119
We conclude that infiltration of CD8+ and CD57+ cells are important prognostic factors in colorectal cancer. PUBMED_ID: 14968119
******************* Regulatory Event *******************
event('Chemical and Drug Induced Liver Injury',association,'CD8A')
subject names: : ['hepatocellular damage', 'hepatitis']
object names: : ['CD8', 'CD8alpha']
Sentences from abstracts:
------------------------
CD28-negative CD8-positive cytotoxic T lymphocytes mediate hepatocellular damage in hepatitis C virus infection. PUBMED_ID: 15031639
CD28(-)CD8(+) T cells may finally function as effector T cells causing the hepatocellular damage in HCV infection. PUBMED_ID: 15031639
******************* Regulatory Event *******************
event('Hepatitis C',negative_correlation,'CD28')
subject names: : ['hepatitis C virus infection', 'hepatitis C virus (HCV) infection', 'HCV infection', 'HCV-infected', 'Anti-HCV', 'anti-HCV', 'HCV genotype 1a infection', 'HCV mono-infection']
object names: : ['CD28']
Sentences from abstracts:
------------------------
CD28-negative CD8-positive cytotoxic T lymphocytes mediate hepatocellular damage in hepatitis C virus infection. PUBMED_ID: 15031639
PBMCs expressing CD8, CD28, CD80, or CD154 were significantly reduced in HCV-infected patients compared with the healthy controls. PUBMED_ID: 15031639
CD28(-)CD8(+) T cells may finally function as effector T cells causing the hepatocellular damage in HCV infection. PUBMED_ID: 15031639
******************* Regulatory Event *******************
event('Hepatitis C',negative_correlation,'CD40LG')
subject names: : ['hepatitis C virus infection', 'hepatitis C virus (HCV) infection', 'HCV infection', 'HCV-infected', 'Anti-HCV', 'anti-HCV', 'HCV genotype 1a infection', 'HCV mono-infection']
object names: : ['CD154', 'CD40L.']
Sentences from abstracts:
------------------------
PBMCs expressing CD8, CD28, CD80, or CD154 were significantly reduced in HCV-infected patients compared with the healthy controls. PUBMED_ID: 15031639
******************* Regulatory Event *******************
event('Hepatitis C',negative_correlation,'CD80')