DATA

DATA folder

expose_[n]_prescr_PD-4prescr-levo-mao-b_age-time-scale_results_atc2level_time-lag[x]years_all.csv

Where n is 2, 4, or 8; and x is 0, 5, 8, or 10.

All the results from the analyses on the entire dataset.

column name	description	format	notes
ATC_code	level 2 ATC code	character	one letter and two digits
pvals	p-value of the Cox-regression HR	numeric
name	description of the ATC code	character string
group	ATC group	character	the first letter of the ATC code
HR	hazard risk	numeric
HR_l	lower bound of 95% confidence interval of the HR value	numeric
HR_u	higher bound of 95% confidence interval of the HR value	numeric
p.adj.FDR	false discovery rate-adjusted p-value	numeric
N.nonpd	number of non-PD users of the drugs	integer
N.pd	number of users that developed PD	integer

Similarly, the files expose_[n]_prescr_PD-4prescr-levo-mao-b_age-time-scale_results_atc2level_time-lag[x]years_men.csv and expose_[n]_prescr_PD-4prescr-levo-mao-b_age-time-scale_results_atc2level_time-lag[x]years_women.csv contain the same type of data but for the sex-stratified analyses.

signif_res_pooled_all.txt

Significant results (i.e., FDR < 0.05) from the pooled analysis.

column name	description	format	notes
ATC_code	level 2 ATC code	character	one letter and two digits
pvals	p-value of the Cox-regression HR	numeric
name	description of the ATC code	character string
group	ATC group	character	the first letter of the ATC code
HR	hazard risk	numeric
HR_l	lower bound of 95% confidence interval of the HR value	numeric
HR_u	higher bound of 95% confidence interval of the HR value	numeric
p.adj.FDR	false discovery rate-adjusted p-value	numeric
N.nonpd	number of non-PD users of the drugs	integer
N.pd	number of users that developed PD	integer
direction_change	which direction is the risk change?	character	two levels: 'increase' or 'decrease'

signif_res_compare_pool_strat.txt

Comparing the significant results from the pooled analysis with the results from the stratified analyses.

n_users_per_ATC_code2_no_sex_exposure[n]_time-lag[x]yrs.txt

Number of users per ATC group, divided into those who were diagnosed with PD and controls.

column name	description	format	notes
park_yn	diagnosed with PD?	boolean
n_users	number of users of the drug	numeric
ATC_code	level 2 ATC code	character	one letter and two digits