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Currently we are considering overlaps with error-rate up to 1%, which might be an overkill, considering identity distribution of the reads post-compression!
Decreasing this threshold might be important for bubble/confusion detection, because we can not easily pose stricter thresholds within individual procedures (for the overlaps, which are expected not to originate from the very same location/haplotype).
Indeed, if we ignore a 0.7% overlap of size 7k, while trying to use a 0.5% threshold, we might miss the fact that it actually had a 'suboverlap' of 0.3% of size 5k.
The text was updated successfully, but these errors were encountered:
This task includes reconsideration (and likely removal) of all the 'stricter' threshold that we might have experimentally introduced in individual procedures.
Currently we are considering overlaps with error-rate up to 1%, which might be an overkill, considering identity distribution of the reads post-compression!
Decreasing this threshold might be important for bubble/confusion detection, because we can not easily pose stricter thresholds within individual procedures (for the overlaps, which are expected not to originate from the very same location/haplotype).
Indeed, if we ignore a 0.7% overlap of size 7k, while trying to use a 0.5% threshold, we might miss the fact that it actually had a 'suboverlap' of 0.3% of size 5k.
The text was updated successfully, but these errors were encountered: