example.queries

Question: What is the mechanism of action for Lepirudin?

Generated SPARQL query:
PREFIX rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#>
PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
PREFIX owl: <http://www.w3.org/2002/07/owl#>
PREFIX xsd: <http://www.w3.org/2001/XMLSchema#>
PREFIX dct: <http://purl.org/dc/terms/>
PREFIX dv: <http://bio2rdf.org/drugbank_vocabulary:>
PREFIX tv: <http://bio2rdf.org/taxonomy_vocabulary:>

SELECT DISTINCT ?mechanism
WHERE {
    ?drug rdf:type dv:Drug .
    ?drug dct:title ?drugTitle .
    FILTER (CONTAINS(LCASE(?drugTitle), "lepirudin"))
    ?drug dv:mechanism-of-action ?mechanismObj .
    ?mechanismObj dct:description ?mechanism .
}

Answer: Lepirudin forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen and initiate the clotting cascade. The inhibition of thrombin prevents the blood clotting cascade.