diff --git a/setup.py b/setup.py
index 8d0e94f6..fd117bef 100644
--- a/setup.py
+++ b/setup.py
@@ -99,7 +99,14 @@ def get_include_files() -> List[Tuple[str, str]]:
     # Dependencies
     install_requires=[
         "nassl>=5.3,<6",
-        "cryptography>=43,<45",
+        # cryptography doesn't use SemVer (they use browser versioning), and
+        # considers its declared API to be stable, even across major version
+        # changes. There may be breaking changes to address security issues,
+        # which has usually meant dropping support for old cryptographic
+        # primitives and protocols:
+        #
+        # https://cryptography.io/en/latest/api-stability/
+        "cryptography>=44.0.1",
         "tls-parser>=2,<3",
         "pydantic>=2.3,<3",
     ],