diff --git a/obi.owl b/obi.owl index 5495774f..aceacdcc 100755 --- a/obi.owl +++ b/obi.owl @@ -13,7 +13,7 @@ xmlns:protege="http://protege.stanford.edu/plugins/owl/protege#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - + en Ontology for Biomedical Investigations Advisors for this project come from the IFOMIS group, Saarbruecken and from the Co-ODE group in Manchester @@ -80,7 +80,7 @@ http://creativecommons.org/licenses/by/4.0/ Ontology for Biomedical Investigations Please cite the OBI consortium http://purl.obolibrary.org/obo/obi where traditional citation is called for. However it is adequate that individual terms be attributed simply by use of the identifying PURL for the term, in projects that refer to them. - 2023-09-20 + 2024-01-09 @@ -1014,12 +1014,6 @@ https://sourceforge.net/tracker/?func=detail&aid=3603413&group_id=177891 - - - - - - @@ -8471,6 +8465,7 @@ https://sourceforge.net/tracker/index.php?func=detail&aid=3512902&group_ MHC protein complex A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen. + MHC protein complex @@ -9016,6 +9011,18 @@ https://sourceforge.net/tracker/index.php?func=detail&aid=3512902&group_ + + + + + Neoplasm + An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor). + + Neoplasm + + + + @@ -12714,6 +12721,369 @@ No imports + + + + + HLA-DR protein complex + + HLA-DR protein complex + + + + + + + + + H2-Db protein complex + + H2-Db protein complex + + + + + + + + + H2-Dd protein complex + + H2-Dd protein complex + + + + + + + + + H2-IA protein complex + + H2-IA protein complex + + + + + + + + + H2-IAd protein complex + + H2-IAd protein complex + + + + + + + + + H2-IAg7 protein complex + + H2-IAg7 protein complex + + + + + + + + + H2-Kb protein complex + + H2-Kb protein complex + + + + + + + + + H2-Kd protein complex + + H2-Kd protein complex + + + + + + + + + H2-Ks protein complex + + H2-Ks protein complex + + + + + + + + + H2-Ld protein complex + + H2-Ld protein complex + + + + + + + + + HLA-C protein complex + + HLA-C protein complex + + + + + + + + + HLA-DP protein complex + + HLA-DP protein complex + + + + + + + + + MHC class I protein complex + + MHC class I protein complex + + + + + + + + + MHC class II protein complex + + MHC class II protein complex + + + + + + + + + cattle MHC class I protein complex + + cattle MHC class I protein complex + + + + + + + + + cattle MHC class II protein complex + + cattle MHC class II protein complex + + + + + + + + + human MHC class I protein complex + + human MHC class I protein complex + + + + + + + + + human MHC class II protein complex + + human MHC class II protein complex + + + + + + + + + mouse MHC class I protein complex + + mouse MHC class I protein complex + + + + + + + + + mouse MHC class II protein complex + + mouse MHC class II protein complex + + + + + + + + + pig MHC class I protein complex + + pig MHC class I protein complex + + + + + + + + + mouse MHC protein complex with H2-p haplotype + + mouse MHC protein complex with H2-p haplotype + + + + + + + + + HLA protein complex with A2 serotype + + HLA protein complex with A2 serotype + + + + + + + + + HLA protein complex with A24 serotype + + HLA protein complex with A24 serotype + + + + + + + + + HLA protein complex with A28 serotype + + HLA protein complex with A28 serotype + + + + + + + + + HLA protein complex with A29 serotype + + HLA protein complex with A29 serotype + + + + + + + + + HLA protein complex with B27 serotype + + HLA protein complex with B27 serotype + + + + + + + + + HLA protein complex with DQ3 serotype + + HLA protein complex with DQ3 serotype + + + + + + + + + mouse MHC class I protein complex with H2-b haplotype + + mouse MHC class I protein complex with H2-b haplotype + + + + + + + + + rat MHC class I protein complex + + rat MHC class I protein complex + + + + + + + + + rat MHC class II protein complex with RT1-A haplotype + + rat MHC class II protein complex with RT1-A haplotype + + + + + + + + + H2-Dq protein complex + + H2-Dq protein complex + + + + + + + + + H2-Kq protein complex + + H2-Kq protein complex + + + + @@ -14567,7 +14937,7 @@ Modification made by JZ. - + reagent role Buffer, dye, a catalyst, a solvating agent. @@ -16571,10 +16941,7 @@ for now. - - - - + @@ -16589,36 +16956,16 @@ for now. - - - - - - - - - - - - - - - - - - - - intraperitoneal injection is the injection of a material entity (bearing the administered substance role) into the peritoneum (bearing the target role) of an organism using a syringe BP - intraperitoneal injection + intraperitoneal injection @@ -18308,16 +18655,13 @@ that has_part some material entity is a material entity. If we add as equivalent - - - - + - + @@ -18330,18 +18674,12 @@ that has_part some material entity is a material entity. If we add as equivalent - - - - - - intraperitoneal administration Rats were injected intraperitoneally with either rrIL-6 (250 ng/0.5 ml) or equal-volume sterile saline twice within an interval of 24 h The administration of a substance into the peritoneum of an organism Person:Bjoern Peters - intraperitoneal administration + intraperitoneal administration @@ -19256,7 +19594,6 @@ that has_part some material entity is a material entity. If we add as equivalent PERSON:Daniel Schober GROUP:<http://msi-ontology.sourceforge.net> http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01072 - check on definition ! solvent mixer @@ -20361,7 +20698,6 @@ that has_part some material entity is a material entity. If we add as equivalent PERSON:Daniel Schober GROUP:<http://msi-ontology.sourceforge.net> http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01055 - chromatography device, check on definition ! column cartridge @@ -20678,7 +21014,6 @@ that has_part some material entity is a material entity. If we add as equivalent PERSON:Daniel Schober GROUP:<http://msi-ontology.sourceforge.net> http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01054 - check on definition ! column cartridger @@ -20709,7 +21044,6 @@ that has_part some material entity is a material entity. If we add as equivalent PERSON:Daniel Schober GROUP:<http://msi-ontology.sourceforge.net> http://msi-ontology.sourceforge.net/ontology/CHROM.owl#msi_01065 - chromatography device, check on definition ! needle assembly @@ -26645,6 +26979,7 @@ http://en.wikipedia.org/wiki/Survival_rate + @@ -26659,20 +26994,6 @@ http://en.wikipedia.org/wiki/Survival_rate - - - - - - - - - - - - - - @@ -26682,7 +27003,7 @@ http://en.wikipedia.org/wiki/Survival_rate oral ingestion of pill - + An adding a material entity to target with the entity is a pill and the target is the mouth Person:Alan Ruttenberg 2009/09/28 Alan Ruttenberg. Fucoidan-use-case @@ -29245,10 +29566,7 @@ Added duirng Mar 1, 2010 dev call - - - - + @@ -29282,12 +29600,6 @@ Added duirng Mar 1, 2010 dev call - - - - - - intramuscular injection is the injection of a material entity (bearing the administered substance role) into the muscle (bearing the target role) of an organism using a syringe @@ -29433,10 +29745,7 @@ Added duirng Mar 1, 2010 dev call - - - - + @@ -29470,12 +29779,6 @@ Added duirng Mar 1, 2010 dev call - - - - - - intradermal injection is the injection of a material entity (bearing the administered substance role) into the dermis (bearing the target role) of an organism using a syringe @@ -29772,12 +30075,6 @@ Biochimie. 2010 Feb 18. - - - - - - oral administration An administering substance in vivo into the mouth of an organism @@ -29819,10 +30116,7 @@ A blood specimen that has been centrifuged to obtain the white blood cells. - - - - + @@ -29856,12 +30150,6 @@ A blood specimen that has been centrifuged to obtain the white blood cells. - - - - - - subcutaneous injection is the injection of a material entity (bearing the administered substance role) into the hypodermis (bearing the target role) of an organism using a syringe @@ -30516,10 +30804,7 @@ In the examples above, a reagent is an operational component of a device, but th - - - - + @@ -30538,12 +30823,6 @@ In the examples above, a reagent is an operational component of a device, but th - - - - - - intranasal mucosal administration The administration of a substance into the intranasal mucosis of an organism @@ -30776,10 +31055,7 @@ In the examples above, a reagent is an operational component of a device, but th - - - - + @@ -30813,12 +31089,6 @@ In the examples above, a reagent is an operational component of a device, but th - - - - - - intravenous injection is the injection of a material entity (bearing the administered substance role) into the vein (bearing the target role) of an organism using a syringe @@ -35509,7 +35779,7 @@ All subtype will be defined by textual definition now. - + @@ -35518,9 +35788,8 @@ All subtype will be defined by textual definition now. passive immunization - Giving VIG (concentrated antibodies from vaccinated donors) to a patient that is infected with smallpox. -Transferring epitope specific T cells from one mouse into another. - + Giving VIG (concentrated antibodies from vaccinated donors) to a patient that is infected with smallpox. Transferring epitope specific T cells from one mouse into another. + The injection of immune effector material (antibodies, T cells or B cells) into an organism so that the organisms immune system gains its immune effector function to recognize specific antigens. PERSON: Bjoern Peters, Randi Vita, Jason Greenbaum adoptive transfer @@ -70619,12 +70888,12 @@ https://www.doi.org/ - Illumina Infinium MethylationEPIC BeadChip + Illumina Infinium MethylationEPIC v1.0 BeadChip An Illumina methylation BeadChip which is an array that interrogates ~ 850,000 methylation sites per sample at single-nucleotide resolution. Person: Chris Stoeckert, Jason Hilton http://www.illumina.com/content/dam/illumina-marketing/documents/products/datasheets/humanmethylationepic-data-sheet-1070-2015-008.pdf - Illumina Infinium MethylationEPIC BeadChip + Illumina Infinium MethylationEPIC v1.0 BeadChip @@ -96689,6 +96958,328 @@ b) that the amount of analyte/measurand detected is over some predetermined thre + + + + + diffusion weighted magnetic resonance image data set + MRI used for assessing structural integrity of brain axons and visualizing ischemia. + + A type of magnetic resonance image data set collected using at least three diffusion gradients of some factor "b," which is a function of the amplitude, duration, and interval of the gradiants. + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://github.com/obi-ontology/obi/issues/1481 + diffusion weighted magnetic resonance image data set + + + + + + + + + functional magnetic resonance image data set + MRI used for assessing brain activity via blood oxygen level dependent signal. + + An magnetic resonance image data set collected as a 4D time series representing changes in brain metabolism (i.e. BOLD), typically used as a proxy for brain activity. + https://orcid.org/0000-0001-9625-1899 "William D. Duncan" + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://orcid.org/0000-0002-2104-0568 "Lucas M. Serra" + https://github.com/obi-ontology/obi/issues/1481 + functional magnetic resonance image data set + + + + + + + + + resting state functional magnetic resonance image data set + An fMRI used for assessing functional connectivity of brain regions at rest. + + A type of functional MRI in which the participant is not given a task, but just rests during acquisision + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://orcid.org/0000-0002-2104-0568 "Lucas M. Serra" + https://github.com/obi-ontology/obi/issues/1481 + resting state functional magnetic resonance image data set + + + + + + + + + task-based functional magnetic resonance image data set + fMRI type used for assessing brain activity while performing an action or in response to stimuli. + + A type of functional MRI in which the participant is given a task or tasks, which are timed with the acquisition + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://orcid.org/0000-0002-2104-0568 "Lucas M. Serra" + https://github.com/obi-ontology/obi/issues/1481 + task-based functional magnetic resonance image data set + + + + + + + + + perfusion weighted magnetic resonance image data set + MRI used for evaluating ischemia. + + An magnetic resonance image data set that captures volume and flow of blood in the brain. + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://github.com/obi-ontology/obi/issues/1481 + perfusion weighted magnetic resonance image data set + + + + + + + + + proton density magnetic resonance image data set + MRI used for visualizing structure of tissue. + + An magnetic resonance image data set in which the contrast emphasizes density of protons, supressing T1 and T2 effects + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://orcid.org/0000-0002-2104-0568 "Lucas M. Serra" + https://github.com/obi-ontology/obi/issues/1481 + proton density magnetic resonance image data set + + + + + + + + + T1 weighted magnetic resonance image data set + MRI used for visualizing structure of tissue where fluid is hypointense. + + An magnetic resonance image acquired using a T1 weighted magnetic resonance image acquisition sequence. + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://orcid.org/0000-0002-2104-0568 "Lucas M. Serra" + https://github.com/obi-ontology/obi/issues/1481 + T1 weighted magnetic resonance image data set + + + + + + + + + post-Gd T1 weighted magnetic resonance image data set + MRI used for assessing breakdown of blood brain barrier. + + A T1 weighted image data set where gadolidium contrast agent has been administered to the participant before image acquistion. + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://orcid.org/0000-0002-2104-0568 "Lucas M. Serra" + https://github.com/obi-ontology/obi/issues/1481 + post-Gd T1 weighted magnetic resonance image data set + + + + + + + + + T1 weighted GRE magnetic resonance image data set + MRI used for computational research on the structure of tissue. + + T1 weighted image data set collected using a gradient recall echo sequence. + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://orcid.org/0000-0002-2104-0568 "Lucas M. Serra" + https://github.com/obi-ontology/obi/issues/1481 + T1 weighted GRE magnetic resonance image data set + + + + + + + + + high resolution T1 weighted magnetic resonance image data set + MRI used for computational segmentation of tissue due to high quality. + + A T1-weighted image data set acquired from an NMR/MRI machine with at least a 3 Tesla magnet and in which the voxel size is isotropic. + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://orcid.org/0000-0002-2104-0568 "Lucas M. Serra" + https://github.com/obi-ontology/obi/issues/1481 + high resolution T1 weighted magnetic resonance image data set + + + + + + + + + baseline high resolution T1 weighted magnetic resonance image data set + First MRI acquired as part of longitudinal study. + + A T1w image data set collected at an evaluant's first visit in a study. + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://orcid.org/0000-0002-2104-0568 "Lucas M. Serra" + https://github.com/obi-ontology/obi/issues/1481 + baseline high resolution T1 weighted magnetic resonance image data set + + + + + + + + + follow-up high resolution T1 weighted magnetic resonance image data set + MRI acquired after the first scan as part of longitudinal study. + + A T1w image data set collected at a later time than the evaluant's first scan. + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://orcid.org/0000-0002-2104-0568 "Lucas M. Serra" + https://github.com/obi-ontology/obi/issues/1481 + follow-up high resolution T1 weighted magnetic resonance image data set + + + + + + + + + T1 weighted SE magnetic resonance image data set + MRI used for visualizing structure of tissue, often of lower quality than a GRE sequence. + + A T1 weighted image data set acquired using a spin echo sequence. + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://orcid.org/0000-0002-2104-0568 "Lucas M. Serra" + https://github.com/obi-ontology/obi/issues/1481 + T1 weighted SE magnetic resonance image data set + + + + + + + + + T2 weighted magnetic resonance image data set + MRI used for visualizing structure of tissue where fluid is hyperintense. + + A magnetic resonance image produced by a T2 weighted magnetic resonance image acquisition sequence. + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://orcid.org/0000-0002-2104-0568 "Lucas M. Serra" + https://github.com/obi-ontology/obi/issues/1481 + T2 weighted magnetic resonance image data set + + + + + + + + + T2 weighted FLAIR magnetic resonance image data set + MRI used for visualizing lesions in multiple sclerosis. + + A T2 weighted image data set collected using a FLAIR sequence. + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://orcid.org/0000-0002-2104-0568 "Lucas M. Serra" + https://github.com/obi-ontology/obi/issues/1481 + T2 weighted FLAIR magnetic resonance image data set + + + + + + + + + T2 weighted FSE magnetic resonance image data set + MRI used for visualizing structure of tissue with fast acquisition times. + + T2 weighted image collected using a fast/turbo spin echo sequence. + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://orcid.org/0000-0002-2104-0568 "Lucas M. Serra" + T2 weighted TSE magnetic resonance image data set + https://github.com/obi-ontology/obi/issues/1481 + T2 weighted FSE magnetic resonance image data set + + + + + + + + + T2 weighted SE magnetic resonance image data set + MRI used for visualizing structure of tissue, often longer acquisition than FSE sequence. + + A type of T2-weighted image in which the acquisition is performed using a 2D spin-echo technique + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://orcid.org/0000-0002-2104-0568 "Lucas M. Serra" + https://github.com/obi-ontology/obi/issues/1481 + T2 weighted SE magnetic resonance image data set + + + + + + + + + T2 weighted STIR magnetic resonance image data set + MRI used for visualizing structure of tissue where signal from fat is suppressed. + + A T2 weighted magnetic resonance image data set collected using a STIR sequence to suppress the signal coming from fat. + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://github.com/obi-ontology/obi/issues/1481 + T2 weighted STIR magnetic resonance image data set + + + + + + + + + T2* weighted GRE magnetic resonance image data set + MRI better suited for identifying focal pathology than T2w SE sequences. + + T2* weighted image data set collected using a gradient echo sequence. + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://orcid.org/0000-0002-2104-0568 "Lucas M. Serra" + https://github.com/obi-ontology/obi/issues/1481 + T2* weighted GRE magnetic resonance image data set + + + + @@ -96782,6 +97373,132 @@ b) that the amount of analyte/measurand detected is over some predetermined thre + + + + + + + + + + + brain region atlas image data set + The Desikan-Killiany brain region atlas used by the FreeSurfer software suite. + + An image data set consisting of values computed from multiple image data sets encoded to represent the spatial location of individual functional or structural regions of a canonical brain. + https://orcid.org/0000-0001-9625-1899 "William D. Duncan" + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://orcid.org/0000-0002-7245-3450 "Lauren M. Wishnie" + https://orcid.org/0000-0002-9821-4132 "Mackenzie T. Smith" + https://github.com/obi-ontology/obi/issues/1481 + brain region atlas image data set + + + + + + + + + probabilistic brain region atlas image dataset + A brain atlas of resting-state functional networks derived from the probability that disparate brains regions are active at the same time. + + A brain atlas consisting of weighted values that respresent the probability that a voxel X is part of some brain component Y, typically derived from multiple image data sets. + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://orcid.org/0000-0002-9821-4132 "Mackenzie T. Smith" + https://github.com/obi-ontology/obi/issues/1481 + probabilistic brain region atlas image dataset + + + + + + + + + deterministic brain region atlas image data set + The JHU white-matter tractography atlas used for mapping brain connectomes. + + A brain atlas consisting of discrete integer values where a value X denotes a voxel is part of some brain component Y. + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://orcid.org/0000-0002-9821-4132 "Mackenzie T. Smith" + https://github.com/obi-ontology/obi/issues/1481 + deterministic brain region atlas image data set + + + + + + + + + image segmentation map + The output of an algorithm that identifies pedestrians walking in a street from an image data set, where the output contains values only in the segment where the pedestrian is present. + + An image data set of integer values in which each value corresponds to some shared characteristic or computed property. The values often belong to a group of pixels or voxels that share the same characteristic, such as a tissue type or anatomical region. + https://orcid.org/0000-0001-9625-1899 "William D. Duncan" + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://orcid.org/0000-0002-7245-3450 "Lauren M. Wishnie" + https://orcid.org/0000-0002-9821-4132 "Mackenzie T. Smith" + https://github.com/obi-ontology/obi/issues/1481 + image segmentation map + + + + + + + + + lesion mask + The output produced by a manual or automated segmentation of lesions from a brain MRI. + + An image data set where voxel intensity values greater than zero encode the location of some brain lesion and voxels outside the lesion have an intensity value of zero. + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://github.com/obi-ontology/obi/issues/1481 + lesion mask + + + + + + + + + T1 lesion mask + The output produced by a manual or automated segmentation of lesions from a T1w MRI. + + A lesion mask where the lesions are derived from a T1 weighted image data set. + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://github.com/obi-ontology/obi/issues/1481 + T1 lesion mask + + + + + + + + + T2 FLAIR lesion mask + The output produced by a manual or automated segmentation of lesions from a T2w FLAIR MRI. + + A lesion mask where the lesions are derived from a T2 FLAIR image data set. + https://orcid.org/0000-0001-9676-7377 "Alexander D. Bartnik" + https://orcid.org/0000-0001-9990-8331 "Alexander D. Diehl" + https://github.com/obi-ontology/obi/issues/1481 + T2 FLAIR lesion mask + + + + @@ -97643,6 +98360,12 @@ b) that the amount of analyte/measurand detected is over some predetermined thre + + + + + + administering substance in vivo to cause disease An administration of substance in vivo with the intention to induce disease in the organism. @@ -97657,6 +98380,20 @@ b) that the amount of analyte/measurand detected is over some predetermined thre + + + + + + + + + + + + + + administering substance in vivo to reduce or prevent disease An administration of substance in vivo with the intention to reduce the symptoms of or prevent development of a disease in the organism. @@ -102182,6 +102919,696 @@ b) that the amount of analyte/measurand detected is over some predetermined thre + + + + + + + + + + + + + + + + + + + + + intragastric administration + + An administration of a substance into the stomach of an organism. + Sebastian Duesing + https://github.com/obi-ontology/obi/issues/1703 + intragastric administration + + + + + + + + + + + + + + + + + + + + + + + + + intracolonic administration + + An administration of a substance into the colon of an organism. + Sebastian Duesing + https://github.com/obi-ontology/obi/issues/1703 + intracolonic administration + + + + + + + + + + + + + + + + + + + + + + + + + vaginal administration + + An administration of a substance into the vagina of an organism. + Sebastian Duesing + https://github.com/obi-ontology/obi/issues/1703 + vaginal administration + + + + + + + + + + + + + + + + + + + + + + + + + topical administration + + An administration of a substance onto the surface of the skin of an organism. + Sebastian Duesing + percutaneous administration + transcutaneous administration + https://github.com/obi-ontology/obi/issues/1703 + topical administration + + + + + + + + + + + + + + + + + + + + + + + + + cervical administration + + An administration of a substance to the cervix of an organism. + Sebastian Duesing + https://github.com/obi-ontology/obi/issues/1703 + cervical administration + + + + + + + + + + + + + + + + + + + + + + + + + conjunctival administration + + An administration of a substance to the conjunctiva of an organism. + Sebastian Duesing + https://github.com/obi-ontology/obi/issues/1703 + conjunctival administration + + + + + + + + + + + + + + + + + + + + + + + + + intratracheal administration + + An administration of a substance into the trachea of an organism. + Sebastian Duesing + https://github.com/obi-ontology/obi/issues/1703 + intratracheal administration + + + + + + + + + + + + + + + + + + + + + + + + + intra-amniotic administration + + An administration of a substance into the amnion of an organism. + Sebastian Duesing + https://github.com/obi-ontology/obi/issues/1703 + intra-amniotic administration + + + + + + + + + + + + + + + + + + + + + + + + + intra-arterial administration + + An administration of a substance into the artery of an organism. + Sebastian Duesing + https://github.com/obi-ontology/obi/issues/1703 + intra-arterial administration + + + + + + + + + + + + + + + + + + + + + + + + + intracerebral administration + + An administration of a substance into the cerebrum of an organism. + Sebastian Duesing + https://github.com/obi-ontology/obi/issues/1703 + intracerebral administration + + + + + + + + + + + + + + + + + + + + + + + + + intracranial administration + + An administration of a substance into the cranium of an organism. + Sebastian Duesing + https://github.com/obi-ontology/obi/issues/1703 + intracranial administration + + + + + + + + + + + + + + + + + + + + + + + + + intraepidermal administration + + An administration of a substance into the epidermis of an organism. + Sebastian Duesing + https://github.com/obi-ontology/obi/issues/1703 + intraepidermal administration + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + intralymphatic administration + + An administration of a substance into the lymphatic system of an organism. + Sebastian Duesing + https://github.com/obi-ontology/obi/issues/1703 + intralymphatic administration + + + + + + + + + + + + + + + + + + + + + + + + + lymph node administration + + An intralymphatic administration in which the substance is administered into a lymph node. + Sebastian Duesing + https://github.com/obi-ontology/obi/issues/1703 + lymph node administration + + + + + + + + + + + + + + + + + + + + + + + + + urethral administration + + An administration of a substance into the urethra of an organism. + Sebastian Duesing + https://github.com/obi-ontology/obi/issues/1703 + urethral administration + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + skin scarification administration + + An intraepidermal administration in which the skin is scratched before the substance is administered to the skin. + Sebastian Duesing + https://github.com/obi-ontology/obi/issues/1703 + skin scarification administration + + + + + + + + + + + + + + + + + + + + + + + + + intrauteral administration + + An adminstration of a substance into the uterus of an organism. + Sebastian Duesing + https://github.com/obi-ontology/obi/issues/1703 + intrauteral administration + + + + + + + + + + + + + + + + + + + + + + + + + intracarotid administration + + An intra-arterial administration in which the substance is administered into the carotid artery. + Sebastian Duesing + i.c. + i.c. administration + https://github.com/obi-ontology/obi/issues/1703 + intracarotid administration + + + + + + + + + + + + + + + + + + + + + + + + + intraocular administration + + An administration of a substance to the eye of an organism. + Sebastian Duesing + https://github.com/obi-ontology/obi/issues/1703 + intraocular administration + + + + + + + + + + + + + + + + + + + + + + + + + intraplacental administration + + An administration of a substance into the placenta of an organism. + Sebastian Duesing + https://github.com/obi-ontology/obi/issues/1703 + intraplacental administration + + + + + + + + + + + + + + + + + + + + + + + + + intrarectal administration + + An administration of a substance into the rectum of an organism. + Sebastian Duesing + https://github.com/obi-ontology/obi/issues/1703 + intrarectal administration + + + + + + + + + + + + + + + + + + + + + + + + + intrasplenic administration + + An administration of a substance into the spleen of an organism. + Sebastian Duesing + https://github.com/obi-ontology/obi/issues/1703 + intrasplenic administration + + + + + + + + + scratching + + A process in which the target material entity is scraped by another material entity. + Sebastian Duesing + abrading + https://github.com/obi-ontology/obi/issues/1703 + scratching + + + + @@ -103125,6 +104552,35 @@ b) that the amount of analyte/measurand detected is over some predetermined thre + + + + + + + + + + + + + + + + + + + + + intratumoral administration + + An administration of a substance into a tumor of an organism. + Sebastian Duesing + intratumoral administration + + + + @@ -103182,6 +104638,1198 @@ b) that the amount of analyte/measurand detected is over some predetermined thre + + + + + disease causation objective + + An objective specification that is fulfilled by causing a disease in a particular organism. + Sebastian Duesing + disease causation objective + + + + + + + + + disease severity reduction objective + + An objective specification that is fulfilled by reducing the severity of a disease in a particular organism. + Sebastian Duesing + disease severity reduction objective + + + + + + + + + disease prevention objective + + An objective specification that is fulfilled by preventing the development of a disease in a particular organism. + Sebastian Duesing + disease prevention objective + + + + + + + + + reactant role + + A role borne by a biological or chemical entity that participates or has molecular components that participate in a chemical reaction. + Sebastian Duesing + reactant role + + + + + + + + + precursor role + + A role borne by a biological or chemical entity which serves as the core component of a chemical reaction process, upon which other reactants, like reagents or solvents, act. + Cameron More + Sebastian Duesing + precursor role + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + electron microscopy assay determining the 3D structure of a T cell epitope:MHC:TCR complex + + An electron-microscopy 3D molecular structure determination assay that characterizes the 3-dimensional molecular structrue of a T cell epitope:MHC:TCR complex. + PERSON:Randi Vita, Sebastian Duesing, Bjoern Peters + IEDB + 3D structure|electron microscopy + electron microscopy assay determining the 3D structure of a T cell epitope:MHC:TCR complex + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + electron microscopy assay determining the 3D structure of a MHC:ligand complex + + An electron-microscopy 3D molecular structure determination assay that characterizes the 3-dimensional molecular structrue of a MHC:ligand complex. + PERSON:Randi Vita, Sebastian Duesing, Bjoern Peters + IEDB + 3D structure|electron microscopy + electron microscopy assay determining the 3D structure of a MHC:ligand complex + + + + + + + + + disease prevalence reduction objective + + An objective specification that is fulfilled by reducing the prevalence of a disease in a population of organisms. + Sebastian Duesing + disease prevalence reduction objective + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + antibody purification of MHC protein complex + + A purification to separate a material entity into different compositions of which one fraction contains a higher concentration of MHC protein complex, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + antibody purification of MHC protein complex + + + + + + + + + + + + + + + + + + + + antibody purification of MHC class I protein complex + + An antibody purification of MHC protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of MHC class I protein complex, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of MHC class I protein complex + + + + + + + + + + + + + + + + + + + + antibody purification of human MHC class I protein complex + + An antibody purification of MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of human MHC class I protein complex, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of human MHC class I protein complex + + + + + + + + + + + + + + + + + + + + antibody purification of HLA protein complex with A2 serotype + + An antibody purification of human MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA protein complex with A2 serotype, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of HLA protein complex with A2 serotype + + + + + + + + + + + + + + + + + + + + antibody purification of HLA protein complex with A24 serotype + + An antibody purification of human MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA protein complex with A24 serotype, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of HLA protein complex with A24 serotype + + + + + + + + + + + + + + + + + + + + + + + + + + + antibody purification of HLA protein complex with A2 serotype and/or HLA protein complex with A28 serotype + + An antibody purification of human MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA protein complex with A2 serotype and/or HLA protein complex with A28 serotype, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of HLA protein complex with A2 serotype and/or HLA protein complex with A28 serotype + + + + + + + + + + + + + + + + + + + + antibody purification of HLA protein complex with A29 serotype + + An antibody purification of human MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA protein complex with A29 serotype, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of HLA protein complex with A29 serotype + + + + + + + + + + + + + + + + + + + + antibody purification of HLA protein complex with B27 serotype + + An antibody purification of human MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA protein complex with B27 serotype, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of HLA protein complex with B27 serotype + + + + + + + + + + + + + + + + + + + + antibody purification of HLA-C protein complex + + An antibody purification of human MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA-C protein complex, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of HLA-C protein complex + + + + + + + + + + + + + + + + + + + + antibody purification of pig MHC class I protein complex + + An antibody purification of MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of pig MHC class I protein complex, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of pig MHC class I protein complex + + + + + + + + + + + + + + + + + + + + antibody purification of cattle MHC class I protein complex + + An antibody purification of MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of cattle MHC class I protein complex, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of cattle MHC class I protein complex + + + + + + + + + + + + + + + + + + + + antibody purification of rat MHC class I protein complex + + An antibody purification of MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of rat MHC class I protein complex, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of rat MHC class I protein complex + + + + + + + + + + + + + + + + + + + + antibody purification of mouse MHC class I protein complex + + An antibody purification of MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of mouse MHC class I protein complex, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of mouse MHC class I protein complex + + + + + + + + + + + + + + + + + + + + antibody purification of H2-Dd protein complex + + An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-Dd protein complex, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of H2-Dd protein complex + + + + + + + + + + + + + + + + + + + + + antibody purification of H2-Db protein complex + + An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-Db protein complex, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of H2-Db protein complex + + + + + + + + + + + + + + + + + + + + antibody purification of H2-Kd protein complex + + An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-Kd protein complex, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of H2-Kd protein complex + + + + + + + + + + + + + + + + + + + + + + + + + + + + antibody purification of H2-Ld protein complex, H2-Db protein complex, and/or H2-Dq protein complex + + An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-Ld protein complex, H2-Db protein complex, and/or H2-Dq protein complex while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of H2-Ld protein complex, H2-Db protein complex, and/or H2-Dq protein complex + + + + + + + + + + + + + + + + + + + + + + + + + + + antibody purification of H2-Dd protein complex and/or H2-Kd protein complex + + An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-Dd protein complex and/or H2-Kd protein complex while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of H2-Dd protein complex and/or H2-Kd protein complex + + + + + + + + + + + + + + + + + + + + + + + + + + + antibody purification of mouse MHC class I protein complex with H2-b haplotype and/or mouse MHC protein complex with H2-p haplotype + + An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of mouse MHC class I protein complex with H2-b haplotype and/or mouse MHC protein complex with H2-p haplotype while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of mouse MHC class I protein complex with H2-b haplotype and/or mouse MHC protein complex with H2-p haplotype + + + + + + + + + + + + + + + + + + + + + + + + + + + + antibody purification of H2-Kb protein complex, H2-Ks protein complex, and/or H2-Kq protein complex + + An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of mouse H2-Kb protein complex, H2-Ks protein complex, and/or H2-Kq protein complex while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of H2-Kb protein complex, H2-Ks protein complex, and/or H2-Kq protein complex + + + + + + + + + + + + + + + + + + + + + + + + + + + + antibody purification of pig MHC class I protein complex, cattle MHC class I protein complex, and/or human MHC class I protein complex + + An antibody purification of MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of pig MHC class I protein complex, cattle MHC class I protein complex, and/or human MHC class I protein complex, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of pig MHC class I protein complex, cattle MHC class I protein complex, and/or human MHC class I protein complex + + + + + + + + + + + + + + + + + + + + antibody purification of MHC class II protein complex + + An antibody purification of MHC protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of MHC class II protein complex, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of MHC class II protein complex + + + + + + + + + + + + + + + + + + + + antibody purification of cattle MHC class II protein complex + + An antibody purification of MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of cattle MHC class II protein complex, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of cattle MHC class II protein complex + + + + + + + + + + + + + + + + + + + + antibody purification of human MHC class II protein complex + + An antibody purification of MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of human MHC class II protein complex, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of human MHC class II protein complex + + + + + + + + + + + + + + + + + + + + antibody purification of HLA-DP protein complex + + An antibody purification of human MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA-DP protein complex, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of HLA-DP protein complex + + + + + + + + + + + + + + + + + + + + antibody purification of HLA-DR protein complex + + An antibody purification of human MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA-DR protein complex, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of HLA-DR protein complex + + + + + + + + + + + + + + + + + + + + antibody purification of HLA protein complex with DQ3 serotype + + An antibody purification of human MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA protein complex with DQ3 serotype, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of HLA protein complex with DQ3 serotype + + + + + + + + + + + + + + + + + + + + antibody purification of mouse MHC class II protein complex + + An antibody purification of MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of mouse MHC class II protein complex, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of mouse MHC class II protein complex + + + + + + + + + + + + + + + + + + + + antibody purification of H2-IA protein complex + + An antibody purification of mouse MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-IA protein complex, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of H2-IA protein complex + + + + + + + + + + + + + + + + + + + + antibody purification of H2-IAg7 protein complex + + An antibody purification of mouse MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-IAg7 protein complex, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of H2-IAg7 protein complex + + + + + + + + + + + + + + + + + + + + antibody purification of H2-IAd protein complex + + An antibody purification of mouse MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-IAd protein complex, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of H2-IAd protein complex + + + + + + + + + + + + + + + + + + + + + + + + + + + antibody purification of mouse MHC class II protein complex and/or rat MHC class II protein complex with RT1-A haplotype + + An antibody purification of MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of mouse MHC class II protein complex and/or rat MHC class II protein complex with RT1-A haplotype, while others contain impurities and are not of interest. + Randi Vita + Sebastian Duesing + Randi Vita + antibody purification of mouse MHC class II protein complex and/or rat MHC class II protein complex with RT1-A haplotype + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + tandem mass spectrometry analysis + + Sebastian Duesing + A mass spectrometry analysis in which the data being analyzed is the result of a tandem mass spectrometry assay. + https://github.com/obi-ontology/obi/issues/1684 + tandem mass spectrometry analysis + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + liquid chromatography mass spectrometry analysis + + Sebastian Duesing + A mass spectrometry analysis in which the data being analyzed is the result of a liquid chromatography mass spectrometry assay. + https://github.com/obi-ontology/obi/issues/1684 + liquid chromatrography mass spectrometry analysis + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + liquid chromatography tandem mass spectrometry analysis + + Sebastian Duesing + A mass spectrometry analysis in which the data being analyzed is the result of a liquid chromatography tandem mass spectrometry assay. + https://github.com/obi-ontology/obi/issues/1684 + liquid chromatography-tandem mass spectrometry analysis + + + + + + + + + Illumina Infinium MethylationEPIC v2.0 BeadChip + + An Illumina methylation BeadChip that targets 935,000 methylation sites per sample at single-nucleotide resolution. + Sebastian Duesing + https://www.illumina.com/products/by-type/microarray-kits/infinium-methylation-epic.html + https://github.com/obi-ontology/obi/issues/1665 + Illumina Infinium MethylationEPIC v2.0 BeadChip + + + + + + + + + multidimensional fatigue inventory score + + A clinical data item that quantifies the severity of a person's fatigue as measured by a 20-item self-report instrument. + Sebastian Duesing + https://pubmed.ncbi.nlm.nih.gov/7636775/ DOI: 10.1016/0022-3999(94)00125-o + multidimensional fatigue inventory score + + + + @@ -103629,7 +106277,7 @@ A cultured cell population maintained in vitro: "Rat cortical neurons from - + primary cultured cell population Spleen cells put directly into culture; Cold storage of biopsies from wild endangered native Chilean species in field conditions and subsequent isolation of primary culture cell lines. In Vitro Cell Dev Biol Anim. 2008 Jul 2. PMID: 18594934 cells that have been isolated from some organismal source, expanded in culture, but not undergone a complete passaging (ie are still in culture, or have been lifted from culture and frozen in aliquots for future use) @@ -103642,7 +106290,7 @@ A cultured cell population maintained in vitro: "Rat cortical neurons from PERSON:Matthew Brush primary cultured cell population - + 0 @@ -103650,7 +106298,7 @@ A cultured cell population maintained in vitro: "Rat cortical neurons from - + consider if we really want to be so strict here . . . ie maybe we we say that they have not been output from an 'establishing cell line' process, but in some cases a passage or two may be allowed for a primary culture. the establishing of a line requires some procedss that attains a degree of homogeneity in the culture. @@ -108003,7 +110651,7 @@ determinations of compounds. - + @@ -114692,11 +117340,11 @@ Possible ecological risks of transgenic organism release when transgenes affect administration in vivo with infectious agent - - is an administration of an infectious agent to a host organism - IEDB - IEDB - administration in vivo with infectious agent + + is an administration of an infectious agent to a host organism + IEDB + IEDB + administration in vivo with infectious agent @@ -115459,7 +118107,7 @@ MHB 3-5-13: Need to review axiom on this class in light of clarification that it IEDB adherent cell culture sample IEDB - cultured adherent cell populaiton + cultured adherent cell population @@ -115672,7 +118320,7 @@ MHB 3-5-13: Need to review axiom on this class in light of clarification that it - + @@ -115712,7 +118360,7 @@ MHB 3-5-13: Need to review axiom on this class in light of clarification that it - + @@ -115720,7 +118368,7 @@ MHB 3-5-13: Need to review axiom on this class in light of clarification that it - + @@ -116824,14 +119472,15 @@ MHB 3-5-13: Need to review axiom on this class in light of clarification that it - - CD8 receptor - + + obsolete CD8 receptor + A transmembrane glycoprotein that serves as a co-receptor for the T cell receptor. - This term does not belong in ONTIE. It should be imported from PRO, but there seems to be no appropriate term as of 08/17/2009. CD8 - WEB: http://en.wikipedia.org/wiki/CD8 - CD8 receptor + https://github.com/obi-ontology/obi/issues/353 + + obsolete CD8 receptor + true @@ -147712,6 +150361,18 @@ realizes some 'host of immune response role' + + + + + amnion + The thin innermost layer of the extraembryonic membranes that contains the amniotic fluid; the membrane forms a closed sac in which the embryo and later, the fetus, is suspended and protected. + + amnion + + + + @@ -147964,6 +150625,18 @@ realizes some 'host of immune response role' + + + + + skin epidermis + The outer epithelial layer of the skin that is superficial to the dermis. + + skin epidermis + + + + @@ -148216,6 +150889,18 @@ realizes some 'host of immune response role' + + + + + common carotid artery plus branches + A bilaterally paired branched artery that originates from the aortic arches and divides into and includes as parts the internal and external carotid arteries[cjm]. + + common carotid artery plus branches + + + + @@ -148279,7 +150964,7 @@ realizes some 'host of immune response role' - + coronary artery An artery that supplies the myocardium. @@ -148288,6 +150973,18 @@ realizes some 'host of immune response role' + + + + + artery + An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition]. + + artery + + + + @@ -148348,6 +151045,18 @@ realizes some 'host of immune response role' + + + + + conjunctiva + The mucous membrane that lines the inner surface of the eyelids and the front of the eyeball. + + conjunctiva + + + + @@ -148408,6 +151117,18 @@ realizes some 'host of immune response role' + + + + + telencephalon + Part of the forebrain consisting of paired olfactory bulbs and cerebral hemispheres. + + telencephalon + + + + @@ -148708,6 +151429,18 @@ realizes some 'host of immune response role' + + + + + lymphoid system + The lymphatic system in vertebrates is a network of conduits that carry a clear fluid called lymph. It also includes the lymphoid tissue through which the lymph travels. Lymphoid tissue is found in many organs, particularly the lymph nodes, and in the lymphoid follicles associated with the digestive system such as the tonsils. The system also includes all the structures dedicated to the circulation and production of lymphocytes, which includes the spleen, thymus, bone marrow and the lymphoid tissue associated with the digestive system[WP]. + + lymphoid system + + + + @@ -148756,6 +151489,18 @@ realizes some 'host of immune response role' + + + + + cranium + Upper portion of the skull that excludes the mandible (when present in the organism). + + cranium + + + + @@ -148902,7 +151647,7 @@ realizes some 'host of immune response role' - + tibial artery The anterior and posterior arteries created at the bifurcation of the popliteal artery. The anterior tibial artery begins at the lower border of the popliteus muscle and lies along the tibia at the distal part of the leg to surface superficially anterior to the ankle joint. Its branches are distributed throughout the leg, ankle, and pes. The posterior tibial artery begins at the lower border of the popliteus muscle, lies behind the tibia in the lower part of its course, and is found situated between the medial malleolus and the medial process of the calcaneal tuberosity. Its branches are distributed throughout the leg and foot. diff --git a/views/NIAID-GSC-BRC.owl b/views/NIAID-GSC-BRC.owl index 6eba5cc0..98ba5558 100644 --- a/views/NIAID-GSC-BRC.owl +++ b/views/NIAID-GSC-BRC.owl @@ -11,7 +11,7 @@ xmlns:terms="http://purl.org/dc/terms/" xmlns:protege="http://protege.stanford.edu/plugins/owl/protege#"> - + en Advisors for this project come from the IFOMIS group, Saarbruecken and from the Co-ODE group in Manchester Alan Ruttenberg @@ -77,7 +77,7 @@ http://creativecommons.org/licenses/by/4.0/ Ontology for Biomedical Investigations Please cite the OBI consortium http://purl.obolibrary.org/obo/obi where traditional citation is called for. However it is adequate that individual terms be attributed simply by use of the identifying PURL for the term, in projects that refer to them. - 2023-09-20 + 2024-01-09 diff --git a/views/obi.obo b/views/obi.obo index 7dd459a5..d45aef7d 100644 --- a/views/obi.obo +++ b/views/obi.obo @@ -1,6 +1,6 @@ format-version: 1.2 -data-version: 2023-09-20 -date: 20:09:2023 10:45 +data-version: 2024-01-09 +date: 09:01:2024 14:43 remark: Please cite the OBI consortium http://purl.obolibrary.org/obo/obi where traditional citation is called for. However it is adequate that individual terms be attributed simply by use of the identifying PURL for the term, in projects that refer to them. ontology: obi property_value: defaultLanguage "en" xsd:string @@ -67,7 +67,7 @@ property_value: http://purl.org/dc/elements/1.1/subject "An ontology for the ann property_value: http://purl.org/dc/terms/license "http://creativecommons.org/licenses/by/4.0/" xsd:string property_value: http://purl.org/dc/terms/title "Ontology for Biomedical Investigations" xsd:string property_value: IAO:0000589 "Ontology for Biomedical Investigations" xsd:string -property_value: owl:versionInfo "2023-09-20" xsd:string +property_value: owl:versionInfo "2024-01-09" xsd:string [Term] id: APOLLO_SV:00000008 @@ -2409,6 +2409,12 @@ name: Insulin resistance def: "Increased resistance towards insulin, that is, diminished effectiveness of insulin in reducing blood glucose levels." [] is_a: BFO:0000016 ! disposition +[Term] +id: HP:0002664 +name: Neoplasm +def: "An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor)." [] +is_a: UBERON:0000465 ! material anatomical entity + [Term] id: IAO:0000001 name: conditional specification @@ -3700,6 +3706,171 @@ name: human pathogenicity disposition def: "A disposition to initiate processes that result in a disorder in a human organism." [] is_a: IDO:0000450 ! pathogenic disposition +[Term] +id: MRO:0000013 +name: HLA-DR protein complex +is_a: MRO:0001455 ! human MHC class II protein complex + +[Term] +id: MRO:0000966 +name: H2-Db protein complex +is_a: MRO:0001759 ! mouse MHC class I protein complex with H2-b haplotype + +[Term] +id: MRO:0000967 +name: H2-Dd protein complex +is_a: MRO:0001460 ! mouse MHC class I protein complex + +[Term] +id: MRO:0000971 +name: H2-IA protein complex +is_a: MRO:0001461 ! mouse MHC class II protein complex + +[Term] +id: MRO:0000973 +name: H2-IAd protein complex +is_a: MRO:0000971 ! H2-IA protein complex + +[Term] +id: MRO:0000975 +name: H2-IAg7 protein complex +is_a: MRO:0000971 ! H2-IA protein complex + +[Term] +id: MRO:0000991 +name: H2-Kb protein complex +is_a: MRO:0001759 ! mouse MHC class I protein complex with H2-b haplotype + +[Term] +id: MRO:0000992 +name: H2-Kd protein complex +is_a: MRO:0001460 ! mouse MHC class I protein complex + +[Term] +id: MRO:0000994 +name: H2-Ks protein complex +is_a: MRO:0001460 ! mouse MHC class I protein complex + +[Term] +id: MRO:0000997 +name: H2-Ld protein complex +is_a: MRO:0001460 ! mouse MHC class I protein complex + +[Term] +id: MRO:0001149 +name: HLA-C protein complex +is_a: MRO:0001454 ! human MHC class I protein complex + +[Term] +id: MRO:0001167 +name: HLA-DP protein complex +is_a: MRO:0001455 ! human MHC class II protein complex + +[Term] +id: MRO:0001355 +name: MHC class I protein complex +is_a: GO:0042611 ! MHC protein complex + +[Term] +id: MRO:0001356 +name: MHC class II protein complex +is_a: GO:0042611 ! MHC protein complex + +[Term] +id: MRO:0001434 +name: cattle MHC class I protein complex +is_a: MRO:0001355 ! MHC class I protein complex + +[Term] +id: MRO:0001435 +name: cattle MHC class II protein complex +is_a: MRO:0001356 ! MHC class II protein complex + +[Term] +id: MRO:0001454 +name: human MHC class I protein complex +is_a: MRO:0001355 ! MHC class I protein complex + +[Term] +id: MRO:0001455 +name: human MHC class II protein complex +is_a: MRO:0001356 ! MHC class II protein complex + +[Term] +id: MRO:0001460 +name: mouse MHC class I protein complex +is_a: MRO:0001355 ! MHC class I protein complex + +[Term] +id: MRO:0001461 +name: mouse MHC class II protein complex +is_a: MRO:0001356 ! MHC class II protein complex + +[Term] +id: MRO:0001465 +name: pig MHC class I protein complex +is_a: MRO:0001355 ! MHC class I protein complex + +[Term] +id: MRO:0001498 +name: mouse MHC protein complex with H2-p haplotype +is_a: GO:0042611 ! MHC protein complex + +[Term] +id: MRO:0001530 +name: HLA protein complex with A2 serotype +is_a: GO:0042611 ! MHC protein complex + +[Term] +id: MRO:0001533 +name: HLA protein complex with A24 serotype +is_a: GO:0042611 ! MHC protein complex + +[Term] +id: MRO:0001537 +name: HLA protein complex with A28 serotype +is_a: GO:0042611 ! MHC protein complex + +[Term] +id: MRO:0001538 +name: HLA protein complex with A29 serotype +is_a: GO:0042611 ! MHC protein complex + +[Term] +id: MRO:0001557 +name: HLA protein complex with B27 serotype +is_a: GO:0042611 ! MHC protein complex + +[Term] +id: MRO:0001622 +name: HLA protein complex with DQ3 serotype +is_a: GO:0042611 ! MHC protein complex + +[Term] +id: MRO:0001759 +name: mouse MHC class I protein complex with H2-b haplotype +is_a: MRO:0001460 ! mouse MHC class I protein complex + +[Term] +id: MRO:0001790 +name: rat MHC class I protein complex +is_a: MRO:0001355 ! MHC class I protein complex + +[Term] +id: MRO:0001793 +name: rat MHC class II protein complex with RT1-A haplotype +is_a: MRO:0001356 ! MHC class II protein complex + +[Term] +id: MRO:0002026 +name: H2-Dq protein complex +is_a: MRO:0001460 ! mouse MHC class I protein complex + +[Term] +id: MRO:0002027 +name: H2-Kq protein complex +is_a: MRO:0001460 ! mouse MHC class I protein complex + [Term] id: NCBITaxon:10090 name: Mus musculus @@ -4433,7 +4604,7 @@ name: reagent role def: "A role inhering in a biological or chemical entity that is intended to be applied in a scientific technique to participate (or have molecular components that participate) in a chemical reaction that facilitates the generation of data about some entity distinct from the bearer, or the generation of some specified material output distinct from the bearer." [] comment: (copied from ReO)\nReagents are distinguished from instruments or devices that also participate in scientific techniques by the fact that reagents are chemical or biological in nature and necessarily participate in or have parts that participate in some chemical interaction or reaction during their intended participation in some technique. By contrast, instruments do not participate in a chemical reaction/interaction during the technique.\n\nReagents are distinguished from study subjects/evaluants in that study subjects and evaluants are that about which conclusions are drawn and knowledge is sought in an investigation - while reagents, by definition, are not. It should be noted, however, that reagent and study subject/evaluant roles can be borne by instances of the same type of material entity - but a given instance will realize only one of these roles in the execution of a given assay or technique. For example, taq polymerase can bear a reagent role or an evaluant role. In a DNA sequencing assay aimed at generating sequence data about some plasmid, the reagent role of the taq polymerase is realized. In an assay to evaluate the quality of the taq polymerase itself, the evaluant/study subject role of the taq is realized, but not the reagent role since the taq is the subject about which data is generated.\n\nIn regard to the statement that reagents are 'distinct' from the specified outputs of a technique, note that a reagent may be incorporated into a material output of a technique, as long as the IDENTITY of this output is distinct from that of the bearer of the reagent role. For example, dNTPs input into a PCR are reagents that become part of the material output of this technique, but this output has a new identity (ie that of a 'nucleic acid molecule') that is distinct from the identity of the dNTPs that comprise it. Similarly, a biotin molecule input into a cell labeling technique are reagents that become part of the specified output, but the identity of the output is that of some modified cell specimen which shares identity with the input unmodified cell specimen, and not with the biotin label. Thus, we see that an important criteria of 'reagent-ness' is that it is a facilitator, and not the primary focus of an investigation or material processing technique (ie not the specified subject/evaluant about which knowledge is sought, or the specified output material of the technique). synonym: "reagent" EXACT [] -is_a: BFO:0000023 ! role +is_a: OBI:0003610 ! reactant role [Term] id: OBI:0000089 @@ -16435,7 +16606,7 @@ is_a: OBI:0001869 ! Illumina BeadChip [Term] id: OBI:0002131 -name: Illumina Infinium MethylationEPIC BeadChip +name: Illumina Infinium MethylationEPIC v1.0 BeadChip def: "An Illumina methylation BeadChip which is an array that interrogates ~ 850,000 methylation sites per sample at single-nucleotide resolution." [] is_a: OBI:0001870 ! Illumina methylation BeadChip @@ -22678,6 +22849,121 @@ def: "An image data set that is the direct output of a raw magnetic resonance im is_a: OBI:0003328 ! magnetic resonance image data set is_a: OBI:0003333 ! computed image data set +[Term] +id: OBI:0003335 +name: diffusion weighted magnetic resonance image data set +def: "A type of magnetic resonance image data set collected using at least three diffusion gradients of some factor \"b,\" which is a function of the amplitude, duration, and interval of the gradiants." [] +is_a: OBI:0003334 ! reconstructed magnetic resonance image data set + +[Term] +id: OBI:0003336 +name: functional magnetic resonance image data set +def: "An magnetic resonance image data set collected as a 4D time series representing changes in brain metabolism (i.e. BOLD), typically used as a proxy for brain activity." [] +is_a: OBI:0003334 ! reconstructed magnetic resonance image data set + +[Term] +id: OBI:0003337 +name: resting state functional magnetic resonance image data set +def: "A type of functional MRI in which the participant is not given a task, but just rests during acquisision" [] +is_a: OBI:0003336 ! functional magnetic resonance image data set + +[Term] +id: OBI:0003338 +name: task-based functional magnetic resonance image data set +def: "A type of functional MRI in which the participant is given a task or tasks, which are timed with the acquisition" [] +is_a: OBI:0003336 ! functional magnetic resonance image data set + +[Term] +id: OBI:0003339 +name: perfusion weighted magnetic resonance image data set +def: "An magnetic resonance image data set that captures volume and flow of blood in the brain." [] +is_a: OBI:0003334 ! reconstructed magnetic resonance image data set + +[Term] +id: OBI:0003340 +name: proton density magnetic resonance image data set +def: "An magnetic resonance image data set in which the contrast emphasizes density of protons, supressing T1 and T2 effects" [] +is_a: OBI:0003334 ! reconstructed magnetic resonance image data set + +[Term] +id: OBI:0003341 +name: T1 weighted magnetic resonance image data set +def: "An magnetic resonance image acquired using a T1 weighted magnetic resonance image acquisition sequence." [] +is_a: OBI:0003334 ! reconstructed magnetic resonance image data set + +[Term] +id: OBI:0003342 +name: post-Gd T1 weighted magnetic resonance image data set +def: "A T1 weighted image data set where gadolidium contrast agent has been administered to the participant before image acquistion." [] +is_a: OBI:0003341 ! T1 weighted magnetic resonance image data set + +[Term] +id: OBI:0003343 +name: T1 weighted GRE magnetic resonance image data set +def: "T1 weighted image data set collected using a gradient recall echo sequence." [] +is_a: OBI:0003341 ! T1 weighted magnetic resonance image data set + +[Term] +id: OBI:0003344 +name: high resolution T1 weighted magnetic resonance image data set +def: "A T1-weighted image data set acquired from an NMR/MRI machine with at least a 3 Tesla magnet and in which the voxel size is isotropic." [] +is_a: OBI:0003343 ! T1 weighted GRE magnetic resonance image data set + +[Term] +id: OBI:0003345 +name: baseline high resolution T1 weighted magnetic resonance image data set +def: "A T1w image data set collected at an evaluant's first visit in a study." [] +is_a: OBI:0003343 ! T1 weighted GRE magnetic resonance image data set + +[Term] +id: OBI:0003346 +name: follow-up high resolution T1 weighted magnetic resonance image data set +def: "A T1w image data set collected at a later time than the evaluant's first scan." [] +is_a: OBI:0003343 ! T1 weighted GRE magnetic resonance image data set + +[Term] +id: OBI:0003347 +name: T1 weighted SE magnetic resonance image data set +def: "A T1 weighted image data set acquired using a spin echo sequence." [] +is_a: OBI:0003341 ! T1 weighted magnetic resonance image data set + +[Term] +id: OBI:0003348 +name: T2 weighted magnetic resonance image data set +def: "A magnetic resonance image produced by a T2 weighted magnetic resonance image acquisition sequence." [] +is_a: OBI:0003334 ! reconstructed magnetic resonance image data set + +[Term] +id: OBI:0003349 +name: T2 weighted FLAIR magnetic resonance image data set +def: "A T2 weighted image data set collected using a FLAIR sequence." [] +is_a: OBI:0003348 ! T2 weighted magnetic resonance image data set + +[Term] +id: OBI:0003350 +name: T2 weighted FSE magnetic resonance image data set +def: "T2 weighted image collected using a fast/turbo spin echo sequence." [] +synonym: "T2 weighted TSE magnetic resonance image data set" EXACT [] +is_a: OBI:0003348 ! T2 weighted magnetic resonance image data set + +[Term] +id: OBI:0003351 +name: T2 weighted SE magnetic resonance image data set +def: "A type of T2-weighted image in which the acquisition is performed using a 2D spin-echo technique" [] +is_a: OBI:0003348 ! T2 weighted magnetic resonance image data set + +[Term] +id: OBI:0003352 +name: T2 weighted STIR magnetic resonance image data set +def: "A T2 weighted magnetic resonance image data set collected using a STIR sequence to suppress the signal coming from fat." [] +is_a: OBI:0003348 ! T2 weighted magnetic resonance image data set + +[Term] +id: OBI:0003353 +name: T2* weighted GRE magnetic resonance image data set +def: "T2* weighted image data set collected using a gradient echo sequence." [] +is_a: OBI:0003348 ! T2 weighted magnetic resonance image data set + [Term] id: OBI:0003354 name: raw magnetic resonance image data set @@ -22698,6 +22984,48 @@ def: "A process that transforms raw magnetic resonance image data from an NMR/MR is_a: APOLLO_SV:00000796 ! dataset creating is_a: OBI:0003355 ! image data set analysis +[Term] +id: OBI:0003357 +name: brain region atlas image data set +def: "An image data set consisting of values computed from multiple image data sets encoded to represent the spatial location of individual functional or structural regions of a canonical brain." [] +is_a: OBI:0003333 ! computed image data set + +[Term] +id: OBI:0003358 +name: probabilistic brain region atlas image dataset +def: "A brain atlas consisting of weighted values that respresent the probability that a voxel X is part of some brain component Y, typically derived from multiple image data sets." [] +is_a: OBI:0003357 ! brain region atlas image data set + +[Term] +id: OBI:0003359 +name: deterministic brain region atlas image data set +def: "A brain atlas consisting of discrete integer values where a value X denotes a voxel is part of some brain component Y." [] +is_a: OBI:0003357 ! brain region atlas image data set + +[Term] +id: OBI:0003360 +name: image segmentation map +def: "An image data set of integer values in which each value corresponds to some shared characteristic or computed property. The values often belong to a group of pixels or voxels that share the same characteristic, such as a tissue type or anatomical region." [] +is_a: OBI:0003333 ! computed image data set + +[Term] +id: OBI:0003361 +name: lesion mask +def: "An image data set where voxel intensity values greater than zero encode the location of some brain lesion and voxels outside the lesion have an intensity value of zero." [] +is_a: OBI:0003360 ! image segmentation map + +[Term] +id: OBI:0003362 +name: T1 lesion mask +def: "A lesion mask where the lesions are derived from a T1 weighted image data set." [] +is_a: OBI:0003361 ! lesion mask + +[Term] +id: OBI:0003363 +name: T2 FLAIR lesion mask +def: "A lesion mask where the lesions are derived from a T2 FLAIR image data set." [] +is_a: OBI:0003361 ! lesion mask + [Term] id: OBI:0003365 name: milk assay datum @@ -23688,6 +24016,149 @@ def: "A chromosome conformation capture assay in which proximity ligation is con synonym: "PLAC-seq" EXACT [] is_a: OBI:0002439 ! chromosome conformation capture assay +[Term] +id: OBI:0003553 +name: intragastric administration +def: "An administration of a substance into the stomach of an organism." [] +is_a: OBI:0600007 ! administering substance in vivo + +[Term] +id: OBI:0003554 +name: intracolonic administration +def: "An administration of a substance into the colon of an organism." [] +is_a: OBI:0600007 ! administering substance in vivo + +[Term] +id: OBI:0003555 +name: vaginal administration +def: "An administration of a substance into the vagina of an organism." [] +is_a: OBI:0600007 ! administering substance in vivo + +[Term] +id: OBI:0003556 +name: topical administration +def: "An administration of a substance onto the surface of the skin of an organism." [] +synonym: "percutaneous administration" EXACT [] +synonym: "transcutaneous administration" EXACT [] +is_a: OBI:0600007 ! administering substance in vivo + +[Term] +id: OBI:0003557 +name: cervical administration +def: "An administration of a substance to the cervix of an organism." [] +is_a: OBI:0600007 ! administering substance in vivo + +[Term] +id: OBI:0003558 +name: conjunctival administration +def: "An administration of a substance to the conjunctiva of an organism." [] +is_a: OBI:0600007 ! administering substance in vivo + +[Term] +id: OBI:0003559 +name: intratracheal administration +def: "An administration of a substance into the trachea of an organism." [] +is_a: OBI:0600007 ! administering substance in vivo + +[Term] +id: OBI:0003560 +name: intra-amniotic administration +def: "An administration of a substance into the amnion of an organism." [] +is_a: OBI:0600007 ! administering substance in vivo + +[Term] +id: OBI:0003561 +name: intra-arterial administration +def: "An administration of a substance into the artery of an organism." [] +is_a: OBI:0600007 ! administering substance in vivo + +[Term] +id: OBI:0003562 +name: intracerebral administration +def: "An administration of a substance into the cerebrum of an organism." [] +is_a: OBI:0600007 ! administering substance in vivo + +[Term] +id: OBI:0003563 +name: intracranial administration +def: "An administration of a substance into the cranium of an organism." [] +is_a: OBI:0600007 ! administering substance in vivo + +[Term] +id: OBI:0003564 +name: intraepidermal administration +def: "An administration of a substance into the epidermis of an organism." [] +is_a: OBI:0600007 ! administering substance in vivo + +[Term] +id: OBI:0003565 +name: intralymphatic administration +def: "An administration of a substance into the lymphatic system of an organism." [] +is_a: OBI:0600007 ! administering substance in vivo + +[Term] +id: OBI:0003566 +name: lymph node administration +def: "An intralymphatic administration in which the substance is administered into a lymph node." [] +is_a: OBI:0003565 ! intralymphatic administration + +[Term] +id: OBI:0003567 +name: urethral administration +def: "An administration of a substance into the urethra of an organism." [] +is_a: OBI:0600007 ! administering substance in vivo + +[Term] +id: OBI:0003568 +name: skin scarification administration +def: "An intraepidermal administration in which the skin is scratched before the substance is administered to the skin." [] +is_a: OBI:0003564 ! intraepidermal administration + +[Term] +id: OBI:0003569 +name: intrauteral administration +def: "An adminstration of a substance into the uterus of an organism. " [] +is_a: OBI:0600007 ! administering substance in vivo + +[Term] +id: OBI:0003570 +name: intracarotid administration +def: "An intra-arterial administration in which the substance is administered into the carotid artery." [] +synonym: "i.c." EXACT [] +synonym: "i.c. administration" EXACT [] +is_a: OBI:0003561 ! intra-arterial administration + +[Term] +id: OBI:0003571 +name: intraocular administration +def: "An administration of a substance to the eye of an organism." [] +is_a: OBI:0600007 ! administering substance in vivo + +[Term] +id: OBI:0003572 +name: intraplacental administration +def: "An administration of a substance into the placenta of an organism." [] +is_a: OBI:0600007 ! administering substance in vivo + +[Term] +id: OBI:0003573 +name: intrarectal administration +def: "An administration of a substance into the rectum of an organism." [] +is_a: OBI:0600007 ! administering substance in vivo + +[Term] +id: OBI:0003574 +name: intrasplenic administration +def: "An administration of a substance into the spleen of an organism." [] +is_a: OBI:0600007 ! administering substance in vivo + +[Term] +id: OBI:0003575 +name: scratching +def: "A process in which the target material entity is scraped by another material entity." [] +synonym: "abrading" EXACT [] +is_a: BFO:0000015 ! process + [Term] id: OBI:0003576 name: skin of body microbiology assay @@ -23845,6 +24316,12 @@ synonym: "QCM measuring KD" EXACT [] is_a: OBI:0001708 ! assay measuring the dissociation constant [KD] of a B cell epitope:antibody complex is_a: OBI:0003601 ! quartz crystal microbalance assay +[Term] +id: OBI:0003603 +name: intratumoral administration +def: "An administration of a substance into a tumor of an organism." [] +is_a: OBI:0600007 ! administering substance in vivo + [Term] id: OBI:0003604 name: multiplexed error-robust fluorescence in situ hybridization assay @@ -23866,6 +24343,279 @@ def: "A DNA sequencer which is manufactured by the Illumina corporation using se synonym: "NextSeq 1000" EXACT [] is_a: OBI:0400103 ! DNA sequencer +[Term] +id: OBI:0003607 +name: disease causation objective +def: "An objective specification that is fulfilled by causing a disease in a particular organism." [] +is_a: IAO:0000005 ! objective specification + +[Term] +id: OBI:0003608 +name: disease severity reduction objective +def: "An objective specification that is fulfilled by reducing the severity of a disease in a particular organism." [] +is_a: IAO:0000005 ! objective specification + +[Term] +id: OBI:0003609 +name: disease prevention objective +def: "An objective specification that is fulfilled by preventing the development of a disease in a particular organism." [] +is_a: IAO:0000005 ! objective specification + +[Term] +id: OBI:0003610 +name: reactant role +def: "A role borne by a biological or chemical entity that participates or has molecular components that participate in a chemical reaction." [] +is_a: BFO:0000023 ! role + +[Term] +id: OBI:0003611 +name: precursor role +def: "A role borne by a biological or chemical entity which serves as the core component of a chemical reaction process, upon which other reactants, like reagents or solvents, act." [] +is_a: OBI:0003610 ! reactant role + +[Term] +id: OBI:0003612 +name: electron microscopy assay determining the 3D structure of a T cell epitope:MHC:TCR complex +def: "An electron-microscopy 3D molecular structure determination assay that characterizes the 3-dimensional molecular structrue of a T cell epitope:MHC:TCR complex." [] +synonym: "3D structure|electron microscopy" EXACT [] +is_a: OBI:0001999 ! 3D molecular structure determination assay of a T cell epitope:MHC:TCR complex +is_a: OBI:0003118 ! electron-microscopy 3D molecular structure determination assay + +[Term] +id: OBI:0003613 +name: electron microscopy assay determining the 3D structure of a MHC:ligand complex +def: "An electron-microscopy 3D molecular structure determination assay that characterizes the 3-dimensional molecular structrue of a MHC:ligand complex." [] +synonym: "3D structure|electron microscopy" EXACT [] +is_a: OBI:0002050 ! 3D molecular structure determination assay of a MHC:ligand complex +is_a: OBI:0003118 ! electron-microscopy 3D molecular structure determination assay + +[Term] +id: OBI:0003614 +name: disease prevalence reduction objective +def: "An objective specification that is fulfilled by reducing the prevalence of a disease in a population of organisms." [] +is_a: IAO:0000005 ! objective specification + +[Term] +id: OBI:0003615 +name: antibody purification of MHC protein complex +def: "A purification to separate a material entity into different compositions of which one fraction contains a higher concentration of MHC protein complex, while others contain impurities and are not of interest." [] +is_a: OBI:0001505 ! purification + +[Term] +id: OBI:0003616 +name: antibody purification of MHC class I protein complex +def: "An antibody purification of MHC protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of MHC class I protein complex, while others contain impurities and are not of interest." [] +is_a: OBI:0003615 ! antibody purification of MHC protein complex + +[Term] +id: OBI:0003617 +name: antibody purification of human MHC class I protein complex +def: "An antibody purification of MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of human MHC class I protein complex, while others contain impurities and are not of interest." [] +is_a: OBI:0003635 ! antibody purification of pig MHC class I protein complex, cattle MHC class I protein complex, and/or human MHC class I protein complex + +[Term] +id: OBI:0003618 +name: antibody purification of HLA protein complex with A2 serotype +def: "An antibody purification of human MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA protein complex with A2 serotype, while others contain impurities and are not of interest." [] +is_a: OBI:0003620 ! antibody purification of HLA protein complex with A2 serotype and/or HLA protein complex with A28 serotype + +[Term] +id: OBI:0003619 +name: antibody purification of HLA protein complex with A24 serotype +def: "An antibody purification of human MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA protein complex with A24 serotype, while others contain impurities and are not of interest." [] +is_a: OBI:0003617 ! antibody purification of human MHC class I protein complex + +[Term] +id: OBI:0003620 +name: antibody purification of HLA protein complex with A2 serotype and/or HLA protein complex with A28 serotype +def: "An antibody purification of human MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA protein complex with A2 serotype and/or HLA protein complex with A28 serotype, while others contain impurities and are not of interest." [] +is_a: OBI:0003617 ! antibody purification of human MHC class I protein complex + +[Term] +id: OBI:0003621 +name: antibody purification of HLA protein complex with A29 serotype +def: "An antibody purification of human MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA protein complex with A29 serotype, while others contain impurities and are not of interest." [] +is_a: OBI:0003617 ! antibody purification of human MHC class I protein complex + +[Term] +id: OBI:0003622 +name: antibody purification of HLA protein complex with B27 serotype +def: "An antibody purification of human MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA protein complex with B27 serotype, while others contain impurities and are not of interest." [] +is_a: OBI:0003617 ! antibody purification of human MHC class I protein complex + +[Term] +id: OBI:0003623 +name: antibody purification of HLA-C protein complex +def: "An antibody purification of human MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA-C protein complex, while others contain impurities and are not of interest." [] +is_a: OBI:0003617 ! antibody purification of human MHC class I protein complex + +[Term] +id: OBI:0003624 +name: antibody purification of pig MHC class I protein complex +def: "An antibody purification of MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of pig MHC class I protein complex, while others contain impurities and are not of interest." [] +is_a: OBI:0003635 ! antibody purification of pig MHC class I protein complex, cattle MHC class I protein complex, and/or human MHC class I protein complex + +[Term] +id: OBI:0003625 +name: antibody purification of cattle MHC class I protein complex +def: "An antibody purification of MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of cattle MHC class I protein complex, while others contain impurities and are not of interest." [] +is_a: OBI:0003635 ! antibody purification of pig MHC class I protein complex, cattle MHC class I protein complex, and/or human MHC class I protein complex + +[Term] +id: OBI:0003626 +name: antibody purification of rat MHC class I protein complex +def: "An antibody purification of MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of rat MHC class I protein complex, while others contain impurities and are not of interest." [] +is_a: OBI:0003616 ! antibody purification of MHC class I protein complex + +[Term] +id: OBI:0003627 +name: antibody purification of mouse MHC class I protein complex +def: "An antibody purification of MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of mouse MHC class I protein complex, while others contain impurities and are not of interest." [] +is_a: OBI:0003616 ! antibody purification of MHC class I protein complex + +[Term] +id: OBI:0003628 +name: antibody purification of H2-Dd protein complex +def: "An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-Dd protein complex, while others contain impurities and are not of interest." [] +is_a: OBI:0003632 ! antibody purification of H2-Dd protein complex and/or H2-Kd protein complex + +[Term] +id: OBI:0003629 +name: antibody purification of H2-Db protein complex +def: "An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-Db protein complex, while others contain impurities and are not of interest." [] +is_a: OBI:0003631 ! antibody purification of H2-Ld protein complex, H2-Db protein complex, and/or H2-Dq protein complex +is_a: OBI:0003633 ! antibody purification of mouse MHC class I protein complex with H2-b haplotype and/or mouse MHC protein complex with H2-p haplotype + +[Term] +id: OBI:0003630 +name: antibody purification of H2-Kd protein complex +def: "An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-Kd protein complex, while others contain impurities and are not of interest." [] +is_a: OBI:0003632 ! antibody purification of H2-Dd protein complex and/or H2-Kd protein complex + +[Term] +id: OBI:0003631 +name: antibody purification of H2-Ld protein complex, H2-Db protein complex, and/or H2-Dq protein complex +def: "An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-Ld protein complex, H2-Db protein complex, and/or H2-Dq protein complex while others contain impurities and are not of interest." [] +is_a: OBI:0003627 ! antibody purification of mouse MHC class I protein complex + +[Term] +id: OBI:0003632 +name: antibody purification of H2-Dd protein complex and/or H2-Kd protein complex +def: "An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-Dd protein complex and/or H2-Kd protein complex while others contain impurities and are not of interest." [] +is_a: OBI:0003627 ! antibody purification of mouse MHC class I protein complex + +[Term] +id: OBI:0003633 +name: antibody purification of mouse MHC class I protein complex with H2-b haplotype and/or mouse MHC protein complex with H2-p haplotype +def: "An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of mouse MHC class I protein complex with H2-b haplotype and/or mouse MHC protein complex with H2-p haplotype while others contain impurities and are not of interest." [] +is_a: OBI:0003627 ! antibody purification of mouse MHC class I protein complex + +[Term] +id: OBI:0003634 +name: antibody purification of H2-Kb protein complex, H2-Ks protein complex, and/or H2-Kq protein complex +def: "An antibody purification of mouse MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of mouse H2-Kb protein complex, H2-Ks protein complex, and/or H2-Kq protein complex while others contain impurities and are not of interest." [] +is_a: OBI:0003627 ! antibody purification of mouse MHC class I protein complex + +[Term] +id: OBI:0003635 +name: antibody purification of pig MHC class I protein complex, cattle MHC class I protein complex, and/or human MHC class I protein complex +def: "An antibody purification of MHC class I protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of pig MHC class I protein complex, cattle MHC class I protein complex, and/or human MHC class I protein complex, while others contain impurities and are not of interest." [] +is_a: OBI:0003616 ! antibody purification of MHC class I protein complex + +[Term] +id: OBI:0003636 +name: antibody purification of MHC class II protein complex +def: "An antibody purification of MHC protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of MHC class II protein complex, while others contain impurities and are not of interest." [] +is_a: OBI:0003615 ! antibody purification of MHC protein complex + +[Term] +id: OBI:0003637 +name: antibody purification of cattle MHC class II protein complex +def: "An antibody purification of MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of cattle MHC class II protein complex, while others contain impurities and are not of interest." [] +is_a: OBI:0003636 ! antibody purification of MHC class II protein complex + +[Term] +id: OBI:0003638 +name: antibody purification of human MHC class II protein complex +def: "An antibody purification of MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of human MHC class II protein complex, while others contain impurities and are not of interest." [] +is_a: OBI:0003636 ! antibody purification of MHC class II protein complex + +[Term] +id: OBI:0003639 +name: antibody purification of HLA-DP protein complex +def: "An antibody purification of human MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA-DP protein complex, while others contain impurities and are not of interest." [] +is_a: OBI:0003638 ! antibody purification of human MHC class II protein complex + +[Term] +id: OBI:0003640 +name: antibody purification of HLA-DR protein complex +def: "An antibody purification of human MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA-DR protein complex, while others contain impurities and are not of interest." [] +is_a: OBI:0003638 ! antibody purification of human MHC class II protein complex + +[Term] +id: OBI:0003641 +name: antibody purification of HLA protein complex with DQ3 serotype +def: "An antibody purification of human MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of HLA protein complex with DQ3 serotype, while others contain impurities and are not of interest." [] +is_a: OBI:0003638 ! antibody purification of human MHC class II protein complex + +[Term] +id: OBI:0003642 +name: antibody purification of mouse MHC class II protein complex +def: "An antibody purification of MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of mouse MHC class II protein complex, while others contain impurities and are not of interest." [] +is_a: OBI:0003646 ! antibody purification of mouse MHC class II protein complex and/or rat MHC class II protein complex with RT1-A haplotype + +[Term] +id: OBI:0003643 +name: antibody purification of H2-IA protein complex +def: "An antibody purification of mouse MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-IA protein complex, while others contain impurities and are not of interest." [] +is_a: OBI:0003642 ! antibody purification of mouse MHC class II protein complex + +[Term] +id: OBI:0003644 +name: antibody purification of H2-IAg7 protein complex +def: "An antibody purification of mouse MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-IAg7 protein complex, while others contain impurities and are not of interest." [] +is_a: OBI:0003643 ! antibody purification of H2-IA protein complex + +[Term] +id: OBI:0003645 +name: antibody purification of H2-IAd protein complex +def: "An antibody purification of mouse MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of H2-IAd protein complex, while others contain impurities and are not of interest." [] +is_a: OBI:0003643 ! antibody purification of H2-IA protein complex + +[Term] +id: OBI:0003646 +name: antibody purification of mouse MHC class II protein complex and/or rat MHC class II protein complex with RT1-A haplotype +def: "An antibody purification of MHC class II protein complex to separate a material entity into different compositions of which one fraction contains a higher concentration of mouse MHC class II protein complex and/or rat MHC class II protein complex with RT1-A haplotype, while others contain impurities and are not of interest." [] +is_a: OBI:0003636 ! antibody purification of MHC class II protein complex + +[Term] +id: OBI:0003647 +name: tandem mass spectrometry analysis +is_a: OBI:0200085 ! mass spectrometry analysis + +[Term] +id: OBI:0003648 +name: liquid chromatrography mass spectrometry analysis +is_a: OBI:0200085 ! mass spectrometry analysis + +[Term] +id: OBI:0003649 +name: liquid chromatography-tandem mass spectrometry analysis +is_a: OBI:0003647 ! tandem mass spectrometry analysis +is_a: OBI:0003648 ! liquid chromatrography mass spectrometry analysis + +[Term] +id: OBI:0003650 +name: Illumina Infinium MethylationEPIC v2.0 BeadChip +def: "An Illumina methylation BeadChip that targets 935,000 methylation sites per sample at single-nucleotide resolution." [] +is_a: OBI:0001870 ! Illumina methylation BeadChip + +[Term] +id: OBI:0003651 +name: multidimensional fatigue inventory score +def: "A clinical data item that quantifies the severity of a person's fatigue as measured by a 20-item self-report instrument." [] +is_a: OGMS:0000123 ! clinical data item + [Term] id: OBI:0005246 name: injection function @@ -25269,7 +26019,7 @@ is_a: BFO:0000023 ! role id: OBI:0302732 name: solvent role def: "solvent role is a role which inheres in a molecular entity capable of ensuring the dissolution of another chemical entity and realized by the process of solvation" [] -is_a: BFO:0000023 ! role +is_a: OBI:0003610 ! reactant role [Term] id: OBI:0302733 @@ -27186,7 +27936,7 @@ is_a: OBI:0001468 ! cell specimen [Term] id: OBI:1110043 -name: cultured adherent cell populaiton +name: cultured adherent cell population def: "A mixed cell population that is characterized by its ability to bind to tissue culture flasks or plates. This population typically contains macrophages and other cells capable of playing the antigen presenting cell role." [] synonym: "adherent cell culture sample" EXACT [] is_a: OBI:0100060 ! cultured cell population @@ -27499,10 +28249,12 @@ is_a: OBI:0002055 ! assay measuring biological activity resulting from T cell ep [Term] id: OBI:1110132 -name: CD8 receptor +name: obsolete CD8 receptor def: "A transmembrane glycoprotein that serves as a co-receptor for the T cell receptor." [] synonym: "CD8" EXACT [] -is_a: PR:000000001 ! protein +is_a: ObsoleteClass ! Obsolete Class +is_obsolete: true +replaced_by: PR:000025402 [Term] id: OBI:1110150 @@ -31298,6 +32050,12 @@ name: blood def: "A fluid that is composed of blood plasma and erythrocytes." [] is_a: UBERON:0006314 ! bodily fluid +[Term] +id: UBERON:0000305 +name: amnion +def: "The thin innermost layer of the extraembryonic membranes that contains the amniotic fluid; the membrane forms a closed sac in which the embryo and later, the fetus, is suspended and protected." [] +is_a: UBERON:0000465 ! material anatomical entity + [Term] id: UBERON:0000310 name: breast @@ -31424,6 +32182,12 @@ name: vagina def: "A fibromuscular tubular tract leading from the uterus to the exterior of the body in female placental mammals and marsupials, or to the cloaca in female birds, monotremes, and some reptiles[WP]." [] is_a: UBERON:0000465 ! material anatomical entity +[Term] +id: UBERON:0001003 +name: skin epidermis +def: "The outer epithelial layer of the skin that is superficial to the dermis." [] +is_a: UBERON:0000483 ! epithelium + [Term] id: UBERON:0001004 name: respiratory system @@ -31550,6 +32314,12 @@ name: ankle joint def: "A joint that connects the hindlimb autopod and zeugopod skeletons." [] is_a: UBERON:0000465 ! material anatomical entity +[Term] +id: UBERON:0001530 +name: common carotid artery plus branches +def: "A bilaterally paired branched artery that originates from the aortic arches and divides into and includes as parts the internal and external carotid arteries[cjm]." [] +is_a: UBERON:0001637 ! artery + [Term] id: UBERON:0001555 name: digestive tract @@ -31584,6 +32354,12 @@ is_a: UBERON:0000465 ! material anatomical entity id: UBERON:0001621 name: coronary artery def: "An artery that supplies the myocardium." [] +is_a: UBERON:0001637 ! artery + +[Term] +id: UBERON:0001637 +name: artery +def: "An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition]." [] is_a: UBERON:0000465 ! material anatomical entity [Term] @@ -31616,6 +32392,12 @@ name: vitreous humor def: "A transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina." [] is_a: UBERON:0000463 ! organism substance +[Term] +id: UBERON:0001811 +name: conjunctiva +def: "The mucous membrane that lines the inner surface of the eyelids and the front of the eyeball." [] +is_a: UBERON:0000465 ! material anatomical entity + [Term] id: UBERON:0001826 name: nasal cavity mucosa @@ -31646,6 +32428,12 @@ name: putamen def: "Subcortical nucleus of telencephalic , which together with the caudate nucleus, forms the striatum. The putamen lies lateral to the internal capsule and medial to the external medullary lamina, and is separated from the caudate nucleus by the fibers of the internal capsule for most of its length, except at its anterior portion." [] is_a: UBERON:0000465 ! material anatomical entity +[Term] +id: UBERON:0001893 +name: telencephalon +def: "Part of the forebrain consisting of paired olfactory bulbs and cerebral hemispheres." [] +is_a: UBERON:0000481 ! multi-tissue structure + [Term] id: UBERON:0001913 name: milk @@ -31796,6 +32584,12 @@ name: tail def: "An external caudal extension of the body. In chordates, the tail is post-anal, in other animals the anus ends in the tail." [] is_a: UBERON:0000465 ! material anatomical entity +[Term] +id: UBERON:0002465 +name: lymphoid system +def: "The lymphatic system in vertebrates is a network of conduits that carry a clear fluid called lymph. It also includes the lymphoid tissue through which the lymph travels. Lymphoid tissue is found in many organs, particularly the lymph nodes, and in the lymphoid follicles associated with the digestive system such as the tonsils. The system also includes all the structures dedicated to the circulation and production of lymphocytes, which includes the spleen, thymus, bone marrow and the lymphoid tissue associated with the digestive system[WP]." [] +is_a: UBERON:0000465 ! material anatomical entity + [Term] id: UBERON:0002469 name: esophagus mucosa @@ -31820,6 +32614,12 @@ name: trachea def: "The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph]." [] is_a: UBERON:0000465 ! material anatomical entity +[Term] +id: UBERON:0003128 +name: cranium +def: "Upper portion of the skull that excludes the mandible (when present in the organism)." [] +is_a: UBERON:0000465 ! material anatomical entity + [Term] id: UBERON:0003688 name: omentum @@ -31895,7 +32695,7 @@ is_a: UBERON:0006538 ! respiratory system fluid/secretion id: UBERON:0007610 name: tibial artery def: "The anterior and posterior arteries created at the bifurcation of the popliteal artery. The anterior tibial artery begins at the lower border of the popliteus muscle and lies along the tibia at the distal part of the leg to surface superficially anterior to the ankle joint. Its branches are distributed throughout the leg, ankle, and pes. The posterior tibial artery begins at the lower border of the popliteus muscle, lies behind the tibia in the lower part of its course, and is found situated between the medial malleolus and the medial process of the calcaneal tuberosity. Its branches are distributed throughout the leg and foot." [] -is_a: UBERON:0000465 ! material anatomical entity +is_a: UBERON:0001637 ! artery [Term] id: UBERON:0007650 diff --git a/views/obi_core.owl b/views/obi_core.owl index 840c80b0..d31d305b 100644 --- a/views/obi_core.owl +++ b/views/obi_core.owl @@ -11,7 +11,7 @@ xmlns:terms="http://purl.org/dc/terms/" xmlns:protege="http://protege.stanford.edu/plugins/owl/protege#"> - + en Ontology for Biomedical Investigations Advisors for this project come from the IFOMIS group, Saarbruecken and from the Co-ODE group in Manchester @@ -78,7 +78,7 @@ http://creativecommons.org/licenses/by/4.0/ Ontology for Biomedical Investigations Please cite the OBI consortium http://purl.obolibrary.org/obo/obi where traditional citation is called for. However it is adequate that individual terms be attributed simply by use of the identifying PURL for the term, in projects that refer to them. - 2023-09-20 + 2024-01-09 @@ -2810,7 +2810,7 @@ editor = PRS - + reagent role Buffer, dye, a catalyst, a solvating agent. @@ -3812,6 +3812,19 @@ The following are NOT conclusions based on data: data themselves; results from p + + + + + reactant role + + A role borne by a biological or chemical entity that participates or has molecular components that participate in a chemical reaction. + Sebastian Duesing + reactant role + + + +