diff --git a/crates/oxc_span/src/span/mod.rs b/crates/oxc_span/src/span/mod.rs
index 0390062584f39..73d9e38282e90 100644
--- a/crates/oxc_span/src/span/mod.rs
+++ b/crates/oxc_span/src/span/mod.rs
@@ -108,8 +108,9 @@ impl Span {
     /// assert!(!Span::new(0, 5).is_unspanned());
     /// assert!(!Span::new(5, 5).is_unspanned());
     /// ```
+    #[inline]
     pub const fn is_unspanned(self) -> bool {
-        self.start == SPAN.start && self.end == SPAN.end
+        self.const_eq(SPAN)
     }
 
     /// Check if this [`Span`] contains another [`Span`].
@@ -360,6 +361,21 @@ impl Span {
             ((self.start as u64) << 32) | (self.end as u64)
         }
     }
+
+    /// Compare two [`Span`]s.
+    ///
+    /// Same as `PartialEq::eq`, but a const function, and takes owned `Span`s.
+    //
+    // `#[inline(always)]` because want to make sure this is inlined into `PartialEq::eq`.
+    #[expect(clippy::inline_always)]
+    #[inline(always)]
+    const fn const_eq(self, other: Self) -> bool {
+        if cfg!(target_pointer_width = "64") {
+            self.as_u64() == other.as_u64()
+        } else {
+            self.start == other.start && self.end == other.end
+        }
+    }
 }
 
 impl Index<Span> for str {
@@ -397,6 +413,15 @@ impl From<Span> for LabeledSpan {
     }
 }
 
+// On 64-bit platforms, compare `Span`s as single `u64`s, which is faster when used with `&Span` refs.
+// https://godbolt.org/z/sEf9MGvsr
+impl PartialEq for Span {
+    #[inline]
+    fn eq(&self, other: &Self) -> bool {
+        self.const_eq(*other)
+    }
+}
+
 // Skip hashing `_align` field.
 // On 64-bit platforms, hash `Span` as a single `u64`, which is faster with `FxHash`.
 // https://godbolt.org/z/4fbvcsTxM
@@ -511,7 +536,13 @@ mod test {
     fn test_eq() {
         assert_eq!(Span::new(0, 0), Span::new(0, 0));
         assert_eq!(Span::new(0, 1), Span::new(0, 1));
+        assert_eq!(Span::new(1, 5), Span::new(1, 5));
+
         assert_ne!(Span::new(0, 0), Span::new(0, 1));
+        assert_ne!(Span::new(1, 5), Span::new(0, 5));
+        assert_ne!(Span::new(1, 5), Span::new(2, 5));
+        assert_ne!(Span::new(1, 5), Span::new(1, 4));
+        assert_ne!(Span::new(1, 5), Span::new(1, 6));
     }
 
     #[test]
diff --git a/crates/oxc_span/src/span/types.rs b/crates/oxc_span/src/span/types.rs
index def2d8619434d..ce1042a50f69d 100644
--- a/crates/oxc_span/src/span/types.rs
+++ b/crates/oxc_span/src/span/types.rs
@@ -59,7 +59,7 @@ use super::PointerAlign;
 /// [`expand`]: Span::expand
 /// [`shrink`]: Span::shrink
 #[ast(visit)]
-#[derive(Default, Clone, Copy, PartialEq, Eq, PartialOrd, Ord)]
+#[derive(Default, Clone, Copy, Eq, PartialOrd, Ord)]
 #[generate_derive(ESTree)]
 #[estree(no_type, always_flatten)]
 pub struct Span {