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compute genomic inflation factor #14

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timflutre opened this issue Dec 14, 2018 · 0 comments
Open

compute genomic inflation factor #14

timflutre opened this issue Dec 14, 2018 · 0 comments

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@timflutre
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Known as lambda:

median(z^2) / 0.455 where qchisq(0.5, 1) = 0.455

The GIANT Consortium, Yang, J., Weedon, M.N., Purcell, S., Lettre, G., Estrada, K., Willer, C.J., Smith, A.V., Ingelsson, E., O’Connell, J.R., et al. (2011). Genomic inflation factors under polygenic inheritance. European Journal of Human Genetics 19, 807–812.

Take p values as inputs and return lambda.
Include it in the function which runs GEMMA uLMM.

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