diff --git a/config/constants.ts b/config/constants.ts
index d34231430..c334512df 100644
--- a/config/constants.ts
+++ b/config/constants.ts
@@ -36,6 +36,9 @@ export const vpcProps: VpcLookupOptions = {
   },
 };
 
+// slack topic for event notification
+export const slackTopicName = 'AwsChatBotTopic';
+
 /**
  * The SSM Parameter Name for HTTP Lambda Authorizer ARN defined in authorization stack manager
  */
diff --git a/config/stacks/icaEventPipe.ts b/config/stacks/icaEventPipe.ts
index f82166dfb..29b2ce703 100644
--- a/config/stacks/icaEventPipe.ts
+++ b/config/stacks/icaEventPipe.ts
@@ -1,11 +1,11 @@
 import { IcaEventPipeStackProps } from '../../lib/workload/stateful/stacks/ica-event-pipe/stack';
-import { eventBusName, icaAwsAccountNumber } from '../constants';
+import { eventBusName, icaAwsAccountNumber, slackTopicName } from '../constants';
 
 export const getIcaEventPipeStackProps = (): IcaEventPipeStackProps => {
   return {
     name: 'IcaEventPipeStack',
     eventBusName: eventBusName,
-    slackTopicName: 'AwsChatBotTopic',
+    slackTopicName: slackTopicName,
     icaAwsAccountNumber: icaAwsAccountNumber,
   };
 };
diff --git a/config/stacks/sequenceRunManager.ts b/config/stacks/sequenceRunManager.ts
index d613f7285..bdcdb1f95 100644
--- a/config/stacks/sequenceRunManager.ts
+++ b/config/stacks/sequenceRunManager.ts
@@ -1,4 +1,5 @@
 import {
+  region,
   AppStage,
   basespaceAccessTokenSecretName,
   cognitoApiGatewayConfig,
@@ -7,10 +8,14 @@ import {
   eventBusName,
   logsApiGatewayConfig,
   vpcProps,
+  slackTopicName,
+  accountIdAlias,
 } from '../constants';
 import { SequenceRunManagerStackProps } from '../../lib/workload/stateless/stacks/sequence-run-manager/deploy/stack';
 
 export const getSequenceRunManagerStackProps = (stage: AppStage): SequenceRunManagerStackProps => {
+  const slackTopicArn =
+    'arn:aws:sns:' + region + ':' + accountIdAlias[stage] + ':' + slackTopicName;
   return {
     vpcProps,
     lambdaSecurityGroupName: computeSecurityGroupName,
@@ -23,5 +28,6 @@ export const getSequenceRunManagerStackProps = (stage: AppStage): SequenceRunMan
       customDomainNamePrefix: 'sequence',
     },
     bsshTokenSecretName: basespaceAccessTokenSecretName,
+    slackTopicArn: slackTopicArn,
   };
 };
diff --git a/lib/workload/stateless/stacks/sequence-run-manager/deploy/stack.ts b/lib/workload/stateless/stacks/sequence-run-manager/deploy/stack.ts
index 237204099..38751be39 100644
--- a/lib/workload/stateless/stacks/sequence-run-manager/deploy/stack.ts
+++ b/lib/workload/stateless/stacks/sequence-run-manager/deploy/stack.ts
@@ -4,7 +4,8 @@ import { aws_lambda, aws_secretsmanager, Duration, Stack } from 'aws-cdk-lib';
 import { Construct } from 'constructs';
 import { ISecurityGroup, IVpc, SecurityGroup, Vpc, VpcLookupOptions } from 'aws-cdk-lib/aws-ec2';
 import { EventBus, IEventBus, Rule } from 'aws-cdk-lib/aws-events';
-import { LambdaFunction } from 'aws-cdk-lib/aws-events-targets';
+import { Topic } from 'aws-cdk-lib/aws-sns';
+import { LambdaFunction, SnsTopic } from 'aws-cdk-lib/aws-events-targets';
 import { PythonFunction, PythonLayerVersion } from '@aws-cdk/aws-lambda-python-alpha';
 import { HttpLambdaIntegration } from 'aws-cdk-lib/aws-apigatewayv2-integrations';
 import {
@@ -24,6 +25,7 @@ export interface SequenceRunManagerStackProps {
   mainBusName: string;
   apiGatewayCognitoProps: ApiGatewayConstructProps;
   bsshTokenSecretName: string;
+  slackTopicArn: string;
 }
 
 export class SequenceRunManagerStack extends Stack {
@@ -92,9 +94,12 @@ export class SequenceRunManagerStack extends Stack {
       compatibleArchitectures: [Architecture.ARM_64],
     });
 
+    const topic: Topic = Topic.fromTopicArn(this, 'SlackTopic', props.slackTopicArn) as Topic;
+
     this.createMigrationHandler();
     this.createApiHandlerAndIntegration(props);
     this.createProcSqsHandler();
+    this.createSlackNotificationHandler(topic);
   }
 
   private createPythonFunction(name: string, props: object): PythonFunction {
@@ -217,4 +222,28 @@ export class SequenceRunManagerStack extends Stack {
 
     eventRule.addTarget(new LambdaFunction(fn));
   }
+
+  private createSlackNotificationHandler(topic: Topic) {
+    /**
+     * subscribe to the 'SequenceRunStateChange' event, and send the slack notification toptic when the failed event is triggered.
+     */
+
+    const eventRule = new Rule(this, this.stackName + 'EventRule', {
+      ruleName: this.stackName + 'EventRule',
+      description: 'Rule to send Failed SequenceRunStateChange events to the SlackTopic',
+      eventBus: this.mainBus,
+    });
+    eventRule.addEventPattern({
+      source: ['orcabus.sequencerunmanager'],
+      detailType: ['SequenceRunStateChange'],
+      detail: {
+        status: ['FAILED'],
+        id: [{ exists: true }],
+        instrumentRunId: [{ exists: true }],
+        sampleSheetName: [{ exists: true }],
+        startTime: [{ exists: true }],
+      },
+    });
+    eventRule.addTarget(new SnsTopic(topic));
+  }
 }