diff --git a/tests/packages/mlx/conftest.py b/tests/packages/mlx/conftest.py
index 4bb0f118a..5562a9a8d 100644
--- a/tests/packages/mlx/conftest.py
+++ b/tests/packages/mlx/conftest.py
@@ -23,3 +23,10 @@ def host_without_mlx_compat_loaded(host_with_saved_yum_state):
     if mlx_compat_loaded:
         logging.info("test is done so reload mlx_compat")
         host.ssh(['modprobe', '-v', 'mlx_compat'])
+
+@pytest.fixture(scope="package")
+def host_without_mlx_card(host):
+    if host.ssh_with_result(["lspci", "|", "grep", "Mellanox"]).returncode == 0:
+        # Skip test to not mess with mellanox card
+        pytest.skip("This test can't be run on a host with a mellanox card")
+    yield host
diff --git a/tests/packages/mlx/test_mellanox-modules-compat.py b/tests/packages/mlx/test_mellanox-modules-compat.py
index 2604f0788..e6a67bef7 100644
--- a/tests/packages/mlx/test_mellanox-modules-compat.py
+++ b/tests/packages/mlx/test_mellanox-modules-compat.py
@@ -1,3 +1,5 @@
+import pytest
+
 # Requirements:
 # From --hosts parameter:
 # - host(A1): any master host of a pool, with access to XCP-ng RPM repositories.
@@ -8,6 +10,7 @@ def load_unload_mlx_module(host):
     host.ssh(['modprobe', '-v', MLX4_MODULE])
     host.ssh(['modprobe', '-r', '-v', MLX4_MODULE])
 
+@pytest.mark.usefixtures("host_without_mlx_card")
 def test_install_mlx_modules_alt(host_without_mlx_compat_loaded):
     host = host_without_mlx_compat_loaded