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Centrifuge is now able to work directly with SRA data: both downloaded on demand over internet and prefetched to local disks.
For example, you can run Centrifuge with SRA data (SRR353653) as follows.
centrifuge -x /path/to/index --sra-acc SRR353653
This eliminates the need to download SRA reads manually and to convert them into fasta/fastq format without affecting the run time.
We provide a Centrifuge index (nt index) for NCBI nucleotide non-redundant sequences collected from plasmids, organelles, viruses, archaea, bacteria, and eukaryotes, totaling ~109 billion bps. Centrifuge is a very good alternative to Megablast (or Blast) for searching through this huge database.
Fixed Centrifuge's scripts related to sequence downloading and index building.