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ID,EVID,TIME,DUR,DOSE,ADDL,II,INPUT,OUT,OUTEQ,C0,C1,C2,C3,WT,AFRICA,AGE,GENDER,HEIGHT | ||
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14,0,126,.,.,.,.,.,7.28,1,.,.,.,.,59.2,1,26,1,174 | ||
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15,0,121,.,.,.,.,.,4.81,1,.,.,.,.,43,1,19,0,150 | ||
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15,0,126,.,.,.,.,.,9.96,1,.,.,.,.,43,1,19,0,150 | ||
15,0,129,.,.,.,.,.,8.55,1,.,.,.,.,43,1,19,0,150 | ||
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18,1,0,0,450,.,.,1,.,.,.,.,.,.,44.3,1,20,0,164 | ||
18,1,24,0,450,.,.,1,.,.,.,.,.,.,44.3,1,20,0,164 | ||
18,1,48,0,450,.,.,1,.,.,.,.,.,.,44.3,1,20,0,164 | ||
18,1,72,0,450,.,.,1,.,.,.,.,.,.,44.3,1,20,0,164 | ||
18,1,96,0,450,.,.,1,.,.,.,.,.,.,44.3,1,20,0,164 | ||
18,0,120,.,.,.,.,.,7.95,1,.,.,.,.,44.3,1,20,0,164 | ||
18,1,120,0,450,.,.,1,.,.,.,.,.,.,44.3,1,20,0,164 | ||
18,0,120.98,.,.,.,.,.,7.47,1,.,.,.,.,44.3,1,20,0,164 | ||
18,0,121.98,.,.,.,.,.,8.67,1,.,.,.,.,44.3,1,20,0,164 | ||
18,0,126,.,.,.,.,.,13.83,1,.,.,.,.,44.3,1,20,0,164 | ||
18,0,129.17,.,.,.,.,.,14.01,1,.,.,.,.,44.3,1,20,0,164 | ||
18,0,132.17,.,.,.,.,.,8.97,1,.,.,.,.,44.3,1,20,0,164 | ||
18,0,143.97,.,.,.,.,.,8.4,1,.,.,.,.,44.3,1,20,0,164 | ||
19,1,0,0,600,.,.,1,.,.,.,.,.,.,50,1,36,1,168 | ||
19,1,24,0,600,.,.,1,.,.,.,.,.,.,50,1,36,1,168 | ||
19,1,48,0,600,.,.,1,.,.,.,.,.,.,50,1,36,1,168 | ||
19,1,72,0,600,.,.,1,.,.,.,.,.,.,50,1,36,1,168 | ||
19,1,96,0,600,.,.,1,.,.,.,.,.,.,50,1,36,1,168 | ||
19,0,120,.,.,.,.,.,5.42,1,.,.,.,.,50,1,36,1,168 | ||
19,1,120,0,600,.,.,1,.,.,.,.,.,.,50,1,36,1,168 | ||
19,0,121,.,.,.,.,.,7.08,1,.,.,.,.,50,1,36,1,168 | ||
19,0,122,.,.,.,.,.,7.27,1,.,.,.,.,50,1,36,1,168 | ||
19,0,125.98,.,.,.,.,.,20.07,1,.,.,.,.,50,1,36,1,168 | ||
19,0,128.98,.,.,.,.,.,18.24,1,.,.,.,.,50,1,36,1,168 | ||
19,0,132,.,.,.,.,.,15.36,1,.,.,.,.,50,1,36,1,168 | ||
19,0,144,.,.,.,.,.,10.92,1,.,.,.,.,50,1,36,1,168 | ||
20,1,0,0,600,.,.,1,.,.,.,.,.,.,59,1,31,1,170 | ||
20,1,24,0,600,.,.,1,.,.,.,.,.,.,59,1,31,1,170 | ||
20,1,48,0,600,.,.,1,.,.,.,.,.,.,59,1,31,1,170 | ||
20,1,72,0,600,.,.,1,.,.,.,.,.,.,59,1,31,1,170 | ||
20,1,96,0,600,.,.,1,.,.,.,.,.,.,59,1,31,1,170 | ||
20,0,120,.,.,.,.,.,4.71,1,.,.,.,.,59,1,31,1,170 | ||
20,1,120,0,600,.,.,1,.,.,.,.,.,.,59,1,31,1,170 | ||
20,0,120.77,.,.,.,.,.,4.5,1,.,.,.,.,59,1,31,1,170 | ||
20,0,121.75,.,.,.,.,.,3.35,1,.,.,.,.,59,1,31,1,170 | ||
20,0,125.67,.,.,.,.,.,12.35,1,.,.,.,.,59,1,31,1,170 | ||
20,0,128.67,.,.,.,.,.,11.56,1,.,.,.,.,59,1,31,1,170 | ||
20,0,143.67,.,.,.,.,.,6.45,1,.,.,.,.,59,1,31,1,170 |
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equation::ODE::new( | ||
|x, p, t, dx, rateiv, cov| { | ||
fetch_params!(p, ka,ke,v0,tlag1); | ||
fetch_cov!(cov, t, wt,africa,age,gender,height); | ||
|
||
let v = v0*(wt/55.0); | ||
|
||
dx[0] = - ka*x[0]; | ||
dx[1] = rateiv[0] + ka*x[0] - ke*x[1]; | ||
}, | ||
|p| { | ||
fetch_params!(p, ka,ke,v0,tlag1); | ||
lag! {0=>tlag1,} | ||
}, | ||
|p| { | ||
fetch_params!(p, ka,ke,v0,tlag1); | ||
fa! {} | ||
}, | ||
|p, t, cov, x| { | ||
fetch_params!(p, ka,ke,v0,tlag1); | ||
fetch_cov!(cov, t, wt,africa,age,gender,height); | ||
|
||
|
||
}, | ||
|x, p, t, cov, y| { | ||
fetch_params!(p, ka,ke,v0,tlag1); | ||
fetch_cov!(cov, t, wt,africa,age,gender,height); | ||
|
||
let v = v0*(wt/55.0); | ||
|
||
y[0] = x[1]/v; | ||
|
||
}, | ||
(2, 1), | ||
) |
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