DNAsty scheme 1 Selection of invariant genes / expression interspersed in lowDim space (scanpy) 2 BEDfile from selected genes 3 Remove SNP from dbSNP above f allelic frequency (pybedtools) 4 split gene into point positions 5 feed the lociList to SCanSNP main walker selection biallelic only?? :S 6 ADATA layer addition (with locus-level information) adata.layer["Alt"] adata.layer["Ref"]