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Update 2024-09-10-cache.markdown
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djcole56 authored Sep 8, 2024
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Expand Up @@ -71,7 +71,7 @@ as well as various 5-membered rings and carboxylic acid bioisosteres.

In particular, the R<sub>1</sub> pocket, which is occupied by a phenyl group in 5RMM, seemed to give opportunities for growth, and the R<sub>3</sub> vector allowed us to merge designs with the 5RLH fragment. This led to designs like the
one shown below (right), which recapitulates many of the fragment interactions and has a good gnina docking
score (1.4 &mu M).
score (1.4 &mu;M).

![](/assets/cache-figs/fig2.png)

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