Skip to content

Releases: kircherlab/cfDNA

v0.3.2

08 Jun 13:23
Compare
Choose a tag to compare

Hotfix: fixed path in get_refsample()

v0.3.1

08 Jun 10:24
Compare
Choose a tag to compare

Hotfix for unexpected behavior in conda dependencies

v0.3.0

31 May 20:09
Compare
Choose a tag to compare
  • updated documentation

  • comfort:

    • added geneIDs to WPS/COV/STARTs and FFT tables
  • snakefile_GE_analysis:

    • added background normalization
    • ported FFT calculation to python
    • separated multiple steps for increased maintainability
  • snakefile_WPS:

    • restructured file paths
    • moved window extension to separate
    • moved WPS padding correction to extractFromBAM_RegionBed_WPS_Cov.py
  • GE_unsupervised:

    • added rules for generating clusterings and heatmaps between all samples of an experiment using FFT intensities
      • kmeans clustering
      • HDBSCAN clustering
      • heatmaps
      • clustermaps (heatmap with hierarchical clustering)

v0.2.1

14 Apr 15:23
Compare
Choose a tag to compare

v0.2.1

  • bugfix paths
  • simplified path handling in plotting scripts
  • improved readability of label files

v0.2.0

01 Apr 10:57
Compare
Choose a tag to compare

refactor

  • changed config.yml to example.config.yml
  • updated schemas
  • updated Documentation

new files

  • updated blacklists for both genome builds
  • updated genome files for both genome builds

new feature

  • snakefile_GE_analysis:

    • updated ProteinAtlas
      • 3 types: Blood, Tissue, Tissue+cell-lines
    • added support for GRCh38
  • snakefile_WPS:

    • added support for normalization by random background sequences
      • generate random background sequences not overlapping target regions
      • calculate WPS,COV,STARTS table for background sequences
  • extractFromBAM_RegionBed_WPS_Cov.py

    • added output for fragment endpoints (STARTS output)
    • added strand specificity
  • overlays.py:

    • integrated normalization by background sequences

v0.1.2

01 Oct 12:55
96adb92
Compare
Choose a tag to compare
  • Updated documentation for config files(fixes #3)

  • Updated overlays.py (resolves #1)

    • adding samples is now wrapped in a function
    • flanking regions are now determined dynamically
  • added CHANGELOG.md