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spisakt committed Apr 29, 2024
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Expand Up @@ -243,7 +243,7 @@ In all analyses, the adaptive splitting procedure is performed with a target pow

The results of our empirical analyses of four large, openly available datasets confirmed that the proposed adaptive splitting approach can successfully identify the optimal time to stop acquiring data for training and maintain a good compromise between maximizing both predictive performance and external validation power with any sample size budget.

In all four samples, the applied models yielded a statistically significant predictive performance at much lower sample sizes than the total size of the dataset, i.e. all datasets were well powered for the analysis. Trained on the full sample size with cross-validation, the models displayed the following performances: functional brain connectivity from the HCP dataset explained 13% of the variance in cognitive abilities; structural MRI data (gray matter probability maps) in the IXI dataset explained 48% in age; c**lassification accuracy was 65.5% for autism diagnosis (functional brain connectivity) in the ABIDE dataset and 92% for breast cancer diagnosis in the BCW dataset.
In all four samples, the applied models yielded a statistically significant predictive performance at much lower sample sizes than the total size of the dataset, i.e. all datasets were well powered for the analysis. Trained on the full sample size with cross-validation, the models displayed the following performances: functional brain connectivity from the HCP dataset explained 13% of the variance in cognitive abilities; structural MRI data (gray matter probability maps) in the IXI dataset explained 48% in age; classification accuracy was 65.5% for autism diagnosis (functional brain connectivity) in the ABIDE dataset and 92% for breast cancer diagnosis in the BCW dataset.

The datasets varied not only in the achievable predictive performance but also in the shape of the learning curve, with different sample sizes and thus, they provided a good opportunity to evaluate the performance of our stopping rule in various circumstances ([Supplementary Figures 1-6](#supplementary-figures)).

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