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Scripts and lists of CpGs which are seen as invariable in GEO data on the 450K

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redgar598/Tissue_Nonvariable_450K_CpGs

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Tissue_Nonvariable_450K_CpGs

Scripts and lists of CpGs which are seen as non-variable in GEO data on the 450K.

Paper available here

https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-017-0320-z

Download CpG List into R

library(RCurl)
x <- getURL("https://raw.githubusercontent.com/redgar598/Tissue_Invariable_450K_CpGs/master/Invariant_Buccal_CpGs.csv")
y <- read.csv(text = x)
nonvariable_buccal<-y$CpG

Validation

In a study of 25 blood samples @lmcewen ~108,000/114,000 blood invariable CpGs were non-variable.

In PAWS @redgar598 (buccals) 99.5% of the buccal non-variable CpGs are also invariable in PAWS

In Lisa's training data (1032 buccals) the overlap was 98,850 out of 120,009 (82%).

In a study of 75 blood samples the overlap was 101,864 out of 102,230 (the number left after other filtering) (99.6%)

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Scripts and lists of CpGs which are seen as invariable in GEO data on the 450K

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