R package implementing the Generalized Binary Covariance Decomposition (GBCD) method for dissecting tumor transcriptional heterogeneity from multi-tumor single-cell RNA-sequencing data.
If you find a bug, or you have a question or feedback on this software, please post an issue.
If you find the gbcd R package or any of the source code in this repository useful for your work, please cite:
Y. Liu, P. Carbonetto, J. Willwerscheid, S. A. Oakes, K. F. Macleod and M. Stephens. Dissecting tumor transcriptional heterogeneity from single-cell RNA-seq data by generalized binary covariance decomposition. Nature Genetics 57, 263-273 (2025).
Install and load the package from GitHub:
# install.packages("remotes")
remotes::install_github("stephenslab/gbcd")See the package documentation and the vignette for more information.
